HitPredict

Interactor 1: WDR5 (P61964)
WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein)
Gene: WDR5

Interactor 2: DYHC1 (Q14204)
Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic)
Gene: DYNC1H1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.80	0.694

Property	Details
Experiments	33022573, 32814053
Identification Methods	affinity chromatography technology, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	AAA_8~WD40, AAA_9~WD40, DHC_N1~WD40
Common GO terms	-
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 334 Hs			1 4646
+	Mm
		925844 LIS1_MOUSE (2-289): 1.02e-94: 288: 29.49		DYHC1_MOUSE (1-4646): 0: 4205: 99.16
+	Hs
		792984 LIS1_HUMAN (2-289): 1.55e-94: 288: 29.49		DYHC1_HUMAN (1-4646): 0: 4190: 100.00
+	Hs
		1051633 FBXW7_HUMAN (198-333): 4.06e-28: 116: 30.15		DYHC1_HUMAN (1-4646): 0: 4190: 100.00
+	Dm
		741114 LIS1_DROME (2-289): 1.19e-91: 281: 27.16		DYHC_DROME (23-4645): 0: 3964: 71.40
+	Hs
		209492 PLRG1_HUMAN (2-333): 5.29e-85: 267: 26.05		DYH17_HUMAN (109-4645): 0: 3714: 23.30
+	Ce
		1090472 LIS1_CAEEL (2-289): 8.81e-87: 268: 24.68		DYHC_CAEEL (37-4643): 0: 3576: 55.20