HitPredict

Interactor 1: WDR5 (P61964)
WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein)
Gene: WDR5

Interactor 2: WDR82 (Q6UXN9)
WD repeat-containing protein 82
Gene: WDR82

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	27705803, 23870121, 20516061
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	WD40~WD40
Common GO terms	GO:0005654 - nucleoplasm GO:0035097 - histone methyltransferase complex GO:0048188 - Set1C/COMPASS complex
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 334 Hs			1 313
+	Hs
		792949 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		LIS1_HUMAN (56-313): 8.55e-73: 231: 17.50
+	Hs
		903349 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		WDR5B_HUMAN (72-312): 1.35e-62: 202: 15.64
+	Hs
		903418 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		FBXW7_HUMAN (93-312): 2.41e-53: 187: 17.49
+	Hs
		196984 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		PRP4_HUMAN (107-313): 1.92e-47: 168: 16.13
+	Hs
		903428 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		SNR40_HUMAN (135-313): 6.85e-40: 144: 13.89
+	Mm
		925836 LIS1_MOUSE (2-289): 1.02e-94: 288: 29.49		LIS1_MOUSE (56-313): 5.56e-73: 232: 17.50
+	Hs
		792935 LIS1_HUMAN (2-289): 1.55e-94: 288: 29.49		LIS1_HUMAN (56-313): 8.55e-73: 231: 17.50
+	Hs
		903551 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		NLE1_HUMAN (184-310): 3.8e-35: 134: 19.70
+	Hs
		903077 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		WDR5_HUMAN (178-311): 9.05e-36: 133: 20.90
+	Hs
		1240442 POC1B_HUMAN (5-251): 5.05e-84: 263: 27.89		POC1A_HUMAN (94-312): 5.17e-62: 203: 18.10
+	Dm
		1358855 WDS_DROME (3-290): 7.53e-92: 279: 31.21		WDR82_DROME (44-312): 9.44e-39: 140: 16.49
+	Hs
		209467 PLRG1_HUMAN (2-333): 5.29e-85: 267: 26.05		SNR40_HUMAN (135-313): 6.85e-40: 144: 13.89
+	Dm
		1358845 WDS_DROME (3-290): 7.53e-92: 279: 31.21		WDS_DROME (181-312): 6.12e-35: 131: 21.21
+	Hs
		1288273 WDR83_HUMAN (25-333): 8.76e-84: 257: 31.83		SNR40_HUMAN (135-313): 6.85e-40: 144: 13.89
+	Hs
		209416 PLRG1_HUMAN (2-333): 5.29e-85: 267: 26.05		WDR5_HUMAN (178-311): 9.05e-36: 133: 20.90
+	Dm
		1358859 WDS_DROME (3-290): 7.53e-92: 279: 31.21		FBXW7_DROME (175-313): 7.4e-29: 118: 21.58
+	Hs
		1146788 WDR83_HUMAN (25-333): 8.76e-84: 257: 31.83		A16L1_HUMAN (16-292): 3.04e-14: 75.1: 21.71
+	Mm
		1207776 WDR83_MOUSE (26-333): 3.34e-84: 258: 32.69		A16L1_MOUSE (16-292): 1.33e-13: 73.2: 22.78