HitPredict

Interactor 1: WDR5 (P61964)
WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein)
Gene: WDR5

Interactor 2: COP1 (Q8NHY2)
E3 ubiquitin-protein ligase COP1 (EC 2.3.2.27) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1) (RING finger and WD repeat domain protein 2) (RING finger protein 200) (RING-type E3 ubiquitin transferase RFWD2)
Gene: COP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17041588
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	WD40~WD40
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 334 Hs			1 731
+	Hs
		903418 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		FBXW7_HUMAN (452-730): 4.46e-69: 242: 17.15
+	Hs
		903349 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		WDR5B_HUMAN (336-625): 1.65e-63: 216: 17.79
+	Hs
		792949 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		LIS1_HUMAN (509-730): 2.11e-55: 197: 21.24
+	Hs
		196984 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		PRP4_HUMAN (511-730): 7.51e-41: 159: 16.59
+	Hs
		903551 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		NLE1_HUMAN (582-729): 3.62e-35: 141: 15.33
+	Hs
		1240442 POC1B_HUMAN (5-251): 5.05e-84: 263: 27.89		POC1A_HUMAN (455-731): 4.3e-69: 234: 22.94
+	Hs
		792935 LIS1_HUMAN (2-289): 1.55e-94: 288: 29.49		LIS1_HUMAN (509-730): 2.11e-55: 197: 21.24
+	Mm
		925836 LIS1_MOUSE (2-289): 1.02e-94: 288: 29.49		LIS1_MOUSE (509-730): 1.47e-55: 197: 21.24
+	Hs
		903171 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		RBBP4_HUMAN (512-702): 3.22e-20: 96: 14.49
+	Hs
		903077 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		WDR5_HUMAN (632-730): 5.38e-16: 81.8: 18.18
+	Hs
		903428 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		SNR40_HUMAN (307-447): 5.3e-10: 63.7: 12.67
+	Hs
		1103007 SMU1_HUMAN (30-331): 7.66e-39: 145: 28.71		FBXW7_HUMAN (452-730): 4.46e-69: 242: 17.15
+	Dm
		1358845 WDS_DROME (3-290): 7.53e-92: 279: 31.21		WDS_DROME (628-730): 1.68e-15: 80.6: 18.45
+	Hs
		209416 PLRG1_HUMAN (2-333): 5.29e-85: 267: 26.05		WDR5_HUMAN (632-730): 5.38e-16: 81.8: 18.18
+	Ce
		954090 LIS1_CAEEL (2-289): 8.81e-87: 268: 24.68		LIN53_CAEEL (552-730): 5.7e-14: 76.7: 16.75
+	Hs
		209467 PLRG1_HUMAN (2-333): 5.29e-85: 267: 26.05		SNR40_HUMAN (307-447): 5.3e-10: 63.7: 12.67
+	Hs
		1288273 WDR83_HUMAN (25-333): 8.76e-84: 257: 31.83		SNR40_HUMAN (307-447): 5.3e-10: 63.7: 12.67
+	Sc
		630844 NLE1_YEAST (167-333): 3.95e-41: 152: 23.70		NLE1_YEAST (595-731): 6.37e-32: 132: 19.01