HitPredict

Interactor 1: CCR5 (P51681)
C-C chemokine receptor type 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) (CHEMR13) (HIV-1 fusion coreceptor) (CD antigen CD195)
Gene: CCR5

Interactor 2: CCL8 (P80075)
C-C motif chemokine 8 (HC14) (Monocyte chemoattractant protein 2) (Monocyte chemotactic protein 2) (MCP-2) (Small-inducible cytokine A8) [Cleaved into: MCP-2(6-76)]
Gene: CCL8

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.776

Property	Details
Experiments	9468473, 10477718
Identification Methods	biochemical, competition binding
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0006816 - calcium ion transport GO:0006935 - chemotaxis GO:0006954 - inflammatory response GO:0007267 - cell-cell signaling
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 352 Hs			1 99
+	Mm
		518941 CCR2_MOUSE (9-352): 3.61e-85: 264: 74.71		CCL2_MOUSE (1-99): 9.84e-37: 122: 50.51
+	Hs
		906999 CCR5_HUMAN (1-352): 1.3e-83: 259: 100.00		CCL13_HUMAN (1-98): 3.22e-37: 122: 62.25
+	Hs
		907075 CCR8_HUMAN (1-348): 2e-92: 281: 41.08		CCL18_HUMAN (1-94): 1.55e-27: 97.7: 30.85
+	Hs
		648028 CCR8_HUMAN (1-348): 2e-92: 281: 41.08		CCL1_HUMAN (1-98): 2.99e-27: 97.3: 30.61
+	Hs
		598257 CCR5_HUMAN (1-352): 1.3e-83: 259: 100.00		CL3L1_HUMAN (1-94): 5.25e-36: 119: 40.43
+	Hs
		561030 CCR5_HUMAN (1-352): 1.3e-83: 259: 100.00		CCL4_HUMAN (1-93): 9.31e-35: 116: 37.63
+	Hs
		907077 CCR8_HUMAN (1-348): 2e-92: 281: 41.08		CCL17_HUMAN (7-91): 3.13e-24: 89.3: 24.71
+	Hs
		518822 CCR5_HUMAN (1-352): 1.3e-83: 259: 100.00		CCL3_HUMAN (1-94): 4.55e-33: 111: 37.23
+	Hs
		562841 CCR5_HUMAN (1-352): 1.3e-83: 259: 100.00		CCL2_HUMAN (1-98): 9.74e-33: 111: 69.39
+	Hs
		906993 CCR5_HUMAN (1-352): 1.3e-83: 259: 100.00		CCL7_HUMAN (17-98): 4.94e-33: 111: 62.20
+	Mm
		907001 CCR5_MOUSE (1-352): 7.3e-84: 259: 81.92		CCL8_MOUSE (1-99): 1.1e-31: 108: 53.54
+	Hs
		191478 CCR8_HUMAN (1-348): 2e-92: 281: 41.08		CCL16_HUMAN (1-89): 1.83e-22: 85.8: 33.70
+	Hs
		906843 CCR5_HUMAN (1-352): 1.3e-83: 259: 100.00		CCL11_HUMAN (1-99): 2.28e-31: 107: 68.69
+	Mm
		907003 CCR2_MOUSE (9-352): 3.61e-85: 264: 74.71		CCL7_MOUSE (1-99): 2.05e-27: 97.7: 52.53
+	Mm
		569687 CCR5_MOUSE (1-352): 7.3e-84: 259: 81.92		CCL4_MOUSE (1-93): 2.58e-29: 102: 36.56
+	Hs
		562884 CCR5_HUMAN (1-352): 1.3e-83: 259: 100.00		CCL5_HUMAN (1-92): 1.3e-25: 92.7: 35.87
+	Hs
		906998 CCR5_HUMAN (1-352): 1.3e-83: 259: 100.00		CCL17_HUMAN (7-91): 3.13e-24: 89.3: 24.71
+	Hs
		191477 CCR5_HUMAN (1-352): 1.3e-83: 259: 100.00		CCL16_HUMAN (1-89): 1.83e-22: 85.8: 33.70
+	Hs
		880434 CX3C1_HUMAN (1-345): 1.55e-82: 256: 38.24		X3CL1_HUMAN (8-95): 2.12e-21: 88.1: 34.07
+	Hs
		141767 ACKR4_HUMAN (2-340): 9.82e-83: 256: 30.35		CCL21_HUMAN (24-99): 2.48e-21: 83.1: 32.91