HitPredict

Interactor 1: CCR5 (P51681)
C-C chemokine receptor type 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) (CHEMR13) (HIV-1 fusion coreceptor) (CD antigen CD195)
Gene: CCR5

Interactor 2: CCL7 (P80098)
C-C motif chemokine 7 (Monocyte chemoattractant protein 3) (Monocyte chemotactic protein 3) (MCP-3) (NC28) (Small-inducible cytokine A7)
Gene: CCL7

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	10477718
Identification Methods	biochemical, competition binding
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0006935 - chemotaxis GO:0006954 - inflammatory response GO:0007267 - cell-cell signaling
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 352 Hs			1 99
+	Mm
		518941 CCR2_MOUSE (9-352): 3.61e-85: 264: 74.71		CCL2_MOUSE (1-94): 2.84e-36: 121: 53.19
+	Hs
		906999 CCR5_HUMAN (1-352): 1.3e-83: 259: 100.00		CCL13_HUMAN (1-98): 1.2e-37: 123: 63.27
+	Hs
		598257 CCR5_HUMAN (1-352): 1.3e-83: 259: 100.00		CL3L1_HUMAN (1-94): 5.48e-36: 119: 36.17
+	Hs
		648028 CCR8_HUMAN (1-348): 2e-92: 281: 41.08		CCL1_HUMAN (1-98): 2.9e-26: 94.7: 33.67
+	Hs
		907075 CCR8_HUMAN (1-348): 2e-92: 281: 41.08		CCL18_HUMAN (1-94): 3.18e-26: 94.3: 35.11
+	Hs
		561030 CCR5_HUMAN (1-352): 1.3e-83: 259: 100.00		CCL4_HUMAN (1-93): 5.93e-35: 116: 37.63
+	Hs
		906992 CCR5_HUMAN (1-352): 1.3e-83: 259: 100.00		CCL8_HUMAN (1-98): 1.57e-34: 115: 65.31
+	Hs
		562841 CCR5_HUMAN (1-352): 1.3e-83: 259: 100.00		CCL2_HUMAN (1-98): 1.53e-33: 113: 74.49
+	Hs
		518822 CCR5_HUMAN (1-352): 1.3e-83: 259: 100.00		CCL3_HUMAN (1-94): 6.46e-33: 111: 34.04
+	Hs
		191478 CCR8_HUMAN (1-348): 2e-92: 281: 41.08		CCL16_HUMAN (1-89): 3.38e-23: 87.7: 33.70
+	Hs
		907077 CCR8_HUMAN (1-348): 2e-92: 281: 41.08		CCL17_HUMAN (6-91): 9.57e-23: 85.8: 34.88
+	Hs
		906843 CCR5_HUMAN (1-352): 1.3e-83: 259: 100.00		CCL11_HUMAN (1-98): 5.34e-31: 106: 69.39
+	Mm
		907001 CCR5_MOUSE (1-352): 7.3e-84: 259: 81.92		CCL8_MOUSE (1-98): 9.23e-31: 106: 45.92
+	Mm
		569687 CCR5_MOUSE (1-352): 7.3e-84: 259: 81.92		CCL4_MOUSE (1-93): 9.5e-30: 103: 35.48
+	Mm
		907003 CCR2_MOUSE (9-352): 3.61e-85: 264: 74.71		CCL7_MOUSE (1-98): 4.13e-27: 97: 62.25
+	Hs
		562884 CCR5_HUMAN (1-352): 1.3e-83: 259: 100.00		CCL5_HUMAN (1-92): 1.87e-25: 92.4: 34.78
+	Hs
		191477 CCR5_HUMAN (1-352): 1.3e-83: 259: 100.00		CCL16_HUMAN (1-89): 3.38e-23: 87.7: 33.70
+	Hs
		880434 CX3C1_HUMAN (1-345): 1.55e-82: 256: 38.24		X3CL1_HUMAN (8-97): 5.09e-22: 90: 31.18
+	Hs
		906998 CCR5_HUMAN (1-352): 1.3e-83: 259: 100.00		CCL17_HUMAN (6-91): 9.57e-23: 85.8: 34.88
+	Hs
		141767 ACKR4_HUMAN (2-340): 9.82e-83: 256: 30.35		CCL21_HUMAN (33-98): 2.49e-18: 75.4: 36.23