HitPredict

Interactor 1: VAMP7 (P51809)
Vesicle-associated membrane protein 7 (VAMP-7) (Synaptobrevin-like protein 1) (Tetanus-insensitive VAMP) (Ti-VAMP)
Gene: VAMP7

Interactor 2: SNAA (P54920)
Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide-sensitive factor attachment protein alpha)
Gene: NAPA

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	30833792, 33961781
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SNAP~Synaptobrevin
Common GO terms	GO:0000149 - SNARE binding GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 220 Hs			1 295
+	Dm
		1171606 Q7JYX5_DROME (1-218): 2.56e-85: 253: 52.29		SNAP_DROME (5-295): 7.88e-105: 308: 61.51
+	Zm
		31396 A0A1D6KH00_MAIZE (2-211): 1.03e-87: 273: 33.02		A0A1D6PZ82_MAIZE (5-272): 3.98e-89: 271: 36.80
+	Hs
		280163 SC22B_HUMAN (23-206): 3.18e-59: 187: 22.16		SNAA_HUMAN (1-295): 2.14e-113: 330: 100.00
+	Hs
		192222 YKT6_HUMAN (23-179): 2.83e-55: 176: 23.42		SNAA_HUMAN (1-295): 2.14e-113: 330: 100.00
+	Hs
		908047 VAMP7_HUMAN (1-220): 2.45e-90: 266: 100.00		SNAG_HUMAN (4-265): 6.78e-68: 215: 23.40
+	Dm
		121790 M9PGI6_DROME (24-204): 1.92e-53: 172: 26.23		SNAP_DROME (5-295): 7.88e-105: 308: 61.51
+	Dm
		305557 O77434_DROME (24-204): 2.65e-53: 172: 26.23		SNAP_DROME (5-295): 7.88e-105: 308: 61.51
+	Dm
		1171638 Q9W3M8_DROME (5-179): 2.97e-51: 166: 21.02		SNAP_DROME (5-295): 7.88e-105: 308: 61.51
+	Dm
		1263454 Q7JYX5_DROME (1-218): 2.56e-85: 253: 52.29		Q9U6R9_DROME (4-265): 3.86e-58: 190: 18.49
+	Sc
		743450 YKT6_YEAST (5-179): 2.6e-52: 168: 22.73		SEC17_YEAST (8-294): 4.65e-88: 266: 34.48
+	Dm
		1263460 Q7JYX5_DROME (1-218): 2.56e-85: 253: 52.29		Q9VH25_DROME (18-265): 1.81e-53: 177: 17.53
+	Sc
		646219 SEC22_YEAST (37-206): 3.5e-49: 161: 20.93		SEC17_YEAST (8-294): 4.65e-88: 266: 34.48
+	Hs
		280315 SC22B_HUMAN (23-206): 3.18e-59: 187: 22.16		SNAG_HUMAN (4-265): 6.78e-68: 215: 23.40
+	Sc
		743495 NYV1_YEAST (36-208): 1.87e-36: 130: 20.21		SEC17_YEAST (8-294): 4.65e-88: 266: 34.48
+	Hs
		192305 YKT6_HUMAN (23-179): 2.83e-55: 176: 23.42		SNAG_HUMAN (4-265): 6.78e-68: 215: 23.40
+	Dm
		121810 M9PGI6_DROME (24-204): 1.92e-53: 172: 26.23		Q9U6R9_DROME (4-265): 3.86e-58: 190: 18.49
+	Dm
		305578 O77434_DROME (24-204): 2.65e-53: 172: 26.23		Q9U6R9_DROME (4-265): 3.86e-58: 190: 18.49
+	Dm
		1458096 Q9W3M8_DROME (5-179): 2.97e-51: 166: 21.02		Q9U6R9_DROME (4-265): 3.86e-58: 190: 18.49
+	Dm
		121816 M9PGI6_DROME (24-204): 1.92e-53: 172: 26.23		Q9VH25_DROME (18-265): 1.81e-53: 177: 17.53
+	Dm
		1475482 Q9W3M8_DROME (5-179): 2.97e-51: 166: 21.02		Q9VH25_DROME (18-265): 1.81e-53: 177: 17.53