HitPredict

Interactor 1: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE

Interactor 2: TBK1 (Q9UHD2)
Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1)
Gene: TBK1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	20462248
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0002753 - cytoplasmic pattern recognition receptor signaling pathway GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019903 - protein phosphatase binding GO:0051219 - phosphoprotein binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 255 Hs			1 729
+	Hs
		909552 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		IKKE_HUMAN (1-716): 4.07e-146: 445: 48.33
+	Hs
		909658 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		MRCKA_HUMAN (6-698): 6.44e-109: 365: 17.31
+	Hs
		625306 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		CDK2_HUMAN (6-312): 1.71e-119: 361: 20.97
+	Hs
		910013 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		SIK2_HUMAN (9-719): 1.2e-110: 359: 15.54
+	Hs
		909447 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		CDK3_HUMAN (6-309): 7.85e-116: 352: 20.20
+	At
		965360 14332_ARATH (4-255): 1.05e-147: 414: 74.41		CIPKC_ARATH (8-452): 1.9e-116: 361: 18.80
+	At
		788672 14333_ARATH (1-253): 3.45e-147: 413: 74.12		CIPKC_ARATH (8-452): 1.9e-116: 361: 18.80
+	At
		1280891 14337_ARATH (2-255): 7.73e-147: 412: 71.21		CIPKC_ARATH (8-452): 1.9e-116: 361: 18.80
+	Hs
		910106 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		MARK1_HUMAN (9-407): 5.07e-87: 292: 23.33
+	Hs
		909916 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		MARK4_HUMAN (9-344): 1.37e-86: 290: 24.48
+	Mm
		910318 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		MARK1_MOUSE (9-407): 3.82e-86: 290: 21.73
+	Mm
		910308 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		MARK4_MOUSE (9-311): 1.98e-86: 289: 25.49
+	Mm
		910231 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		MARK3_MOUSE (9-267): 1.16e-85: 288: 28.46
+	Hs
		647862 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		MARK3_HUMAN (9-267): 1.86e-85: 287: 28.08
+	Xl
		223344 O57468_XENLA (1-255): 1.7e-152: 426: 96.47		Q804T2_XENLA (9-293): 7.08e-86: 288: 26.60
+	Hs
		262252 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		ULK1_HUMAN (13-222): 2.86e-26: 117: 34.10
+	Hs
		909795 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		ULK2_HUMAN (13-222): 2.85e-25: 114: 33.80
+	Sc
		605967 BMH2_YEAST (4-242): 1.14e-134: 382: 77.08		RAD53_YEAST (10-221): 1.29e-22: 105: 31.65