HitPredict

Interactor 1: MRCKA (Q5VT25)
Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha)
Gene: CDC42BPA

Interactor 2: RND1 (Q92730)
Rho-related GTP-binding protein Rho6 (Rho family GTPase 1) (Rnd1)
Gene: RND1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C1_1~Ras, Pkinase~Ras
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1732 Hs			1 232
+	Hs
		962764 MRCKA_HUMAN (1-1732): 0: 1630: 100.00		RND3_HUMAN (1-232): 9.61e-101: 294: 58.20
+	Hs
		910090 MRCKA_HUMAN (1-1732): 0: 1630: 100.00		RND2_HUMAN (12-232): 9.66e-80: 240: 53.15
+	Hs
		988432 MRCKA_HUMAN (1-1732): 0: 1630: 100.00		RAC1_HUMAN (11-200): 6.09e-79: 237: 38.42
+	Hs
		1015512 MRCKA_HUMAN (1-1732): 0: 1630: 100.00		RHOG_HUMAN (11-198): 4.17e-78: 234: 37.77
+	Hs
		581101 MRCKA_HUMAN (1-1732): 0: 1630: 100.00		RAC2_HUMAN (11-201): 8.33e-76: 229: 38.22
+	Hs
		953499 MRCKA_HUMAN (1-1732): 0: 1630: 100.00		RAC3_HUMAN (11-188): 6.07e-76: 229: 39.89
+	Hs
		962148 MRCKA_HUMAN (1-1732): 0: 1630: 100.00		RHOA_HUMAN (15-197): 9.94e-75: 226: 43.17
+	Hs
		955277 MRCKA_HUMAN (1-1732): 0: 1630: 100.00		CDC42_HUMAN (11-198): 1.38e-74: 225: 37.23
+	Hs
		978071 MRCKA_HUMAN (1-1732): 0: 1630: 100.00		RHOB_HUMAN (13-190): 2.92e-49: 161: 44.94
+	Hs
		126642 MRCKA_HUMAN (1-1732): 0: 1630: 100.00		RHOD_HUMAN (6-189): 1.8e-48: 160: 40.76
+	Hs
		1217566 MRCKA_HUMAN (1-1732): 0: 1630: 100.00		RHOF_HUMAN (1-189): 2.34e-44: 149: 40.21
+	Hs
		962870 MRCKB_HUMAN (1-1731): 0: 1429: 60.38		RND3_HUMAN (1-232): 9.61e-101: 294: 58.20
+	Hs
		910271 MRCKB_HUMAN (1-1731): 0: 1429: 60.38		RND2_HUMAN (12-232): 9.66e-80: 240: 53.15
+	Hs
		988860 MRCKB_HUMAN (1-1731): 0: 1429: 60.38		RAC1_HUMAN (11-200): 6.09e-79: 237: 38.42
+	Hs
		581399 MRCKB_HUMAN (1-1731): 0: 1429: 60.38		RAC2_HUMAN (11-201): 8.33e-76: 229: 38.22
+	Hs
		953780 MRCKB_HUMAN (1-1731): 0: 1429: 60.38		RAC3_HUMAN (11-188): 6.07e-76: 229: 39.89
+	Hs
		962678 MRCKB_HUMAN (1-1731): 0: 1429: 60.38		RHOA_HUMAN (15-197): 9.94e-75: 226: 43.17
+	Hs
		955794 MRCKB_HUMAN (1-1731): 0: 1429: 60.38		CDC42_HUMAN (11-198): 1.38e-74: 225: 37.23
+	Hs
		978431 MRCKB_HUMAN (1-1731): 0: 1429: 60.38		RHOB_HUMAN (13-190): 2.92e-49: 161: 44.94
+	Hs
		126895 MRCKB_HUMAN (1-1731): 0: 1429: 60.38		RHOD_HUMAN (6-189): 1.8e-48: 160: 40.76