HitPredict

Interactor 1: ARF6 (P62330)
ADP-ribosylation factor 6 (EC 3.6.5.2)
Gene: ARF6

Interactor 2: PKHA5 (Q9HAU0)
Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2)
Gene: PLEKHA5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Arf~PH
Common GO terms	GO:0005829 - cytosol GO:0016020 - membrane GO:0098978 - glutamatergic synapse
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 175 Hs			1 1116
+	Hs
		912962 ARF6_HUMAN (1-175): 2.17e-65: 199: 100.00		PKHA7_HUMAN (2-1059): 8.31e-125: 412: 27.32
+	Mm
		950595 ARF5_MOUSE (2-173): 4.69e-69: 209: 65.12		CAPS2_MOUSE (70-775): 5.81e-63: 236: 11.45
+	Mm
		901642 ARF4_MOUSE (1-173): 5.64e-69: 208: 64.74		CAPS2_MOUSE (70-775): 5.81e-63: 236: 11.45
+	Hs
		912911 ARF6_HUMAN (1-175): 2.17e-65: 199: 100.00		ACAP2_HUMAN (128-692): 2.59e-47: 184: 13.38
+	Hs
		574749 ARF4_HUMAN (1-173): 1.32e-70: 212: 64.74		PKHA4_HUMAN (142-851): 4.17e-38: 155: 16.85
+	Hs
		950560 ARF1_HUMAN (2-175): 4.43e-69: 209: 68.39		PKHA4_HUMAN (142-851): 4.17e-38: 155: 16.85
+	Hs
		950712 ARF5_HUMAN (2-173): 4.69e-69: 209: 65.12		PKHA4_HUMAN (142-851): 4.17e-38: 155: 16.85
+	Hs
		913123 ARF6_HUMAN (1-175): 2.17e-65: 199: 100.00		PKHA1_HUMAN (161-359): 9.87e-42: 160: 19.43
+	Hs
		918949 RAB1A_HUMAN (1-174): 6.74e-67: 204: 18.99		PKHA4_HUMAN (142-851): 4.17e-38: 155: 16.85
+	Hs
		1328144 RAB1B_HUMAN (10-174): 1.3e-66: 203: 19.41		PKHA4_HUMAN (142-851): 4.17e-38: 155: 16.85
+	Hs
		913111 ARF6_HUMAN (1-175): 2.17e-65: 199: 100.00		PKHA4_HUMAN (142-851): 4.17e-38: 155: 16.85
+	Hs
		897405 ARF3_HUMAN (2-175): 4.91e-65: 198: 69.54		PKHA4_HUMAN (142-851): 4.17e-38: 155: 16.85
+	Hs
		125370 ARF1_HUMAN (2-175): 4.43e-69: 209: 68.39		WWP2_HUMAN (10-213): 2.29e-27: 122: 19.51
+	Hs
		574746 ARF4_HUMAN (1-173): 1.32e-70: 212: 64.74		WWP1_HUMAN (3-240): 7.83e-24: 110: 14.94
+	Hs
		950704 ARF5_HUMAN (2-173): 4.69e-69: 209: 65.12		WWP1_HUMAN (3-240): 7.83e-24: 110: 14.94
+	Hs
		913021 ARF6_HUMAN (1-175): 2.17e-65: 199: 100.00		TITIN_HUMAN (275-1090): 3.45e-10: 67: 9.15