HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: SPTN1 (Q13813)
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit)
Gene: SPTAN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	12577067
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	SH2~SH3_1, SH3_1~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0030036 - actin cytoskeleton organization GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 2472
+	Hs
		411715 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		SPTN1_HUMAN (1-2472): 0: 714: 100.00
+	Hs
		337470 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		SPTN1_HUMAN (1-2472): 0: 714: 100.00
+	Hs
		1045423 ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00		SPTN1_HUMAN (1-2472): 0: 714: 100.00
+	Hs
		337296 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		SPTA1_HUMAN (1-2472): 2.98e-159: 552: 54.81
+	Hs
		924482 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52
+	Hs
		164551 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		SPTN2_HUMAN (141-1932): 1.25e-65: 250: 20.41
+	Hs
		924491 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		DYST_HUMAN (5-2410): 1.41e-35: 152: 10.59
+	Hs
		924586 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PLEC_HUMAN (16-1253): 4.4e-31: 137: 9.18
+	Hs
		411676 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52
+	Hs
		521521 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		ACTN1_HUMAN (1862-2210): 3.16e-11: 71.2: 22.25
+	Hs
		411724 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		GOGB1_HUMAN (2-1186): 3.65e-38: 160: 10.57
+	Hs
		211557 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		ACTN4_HUMAN (1843-2219): 1.15e-09: 66.2: 20.15
+	Hs
		411682 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		DYST_HUMAN (5-2410): 1.41e-35: 152: 10.59
+	Hs
		963335 ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00		SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52
+	Hs
		1059285 ITSN2_HUMAN (2-61): 5.91e-15: 75: 36.67		GOGB1_HUMAN (2-1186): 3.65e-38: 160: 10.57
+	Hs
		411889 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		MACF1_HUMAN (9-1261): 9.1e-18: 93.6: 12.48
+	Hs
		974160 ITSN2_HUMAN (2-61): 5.91e-15: 75: 36.67		DYST_HUMAN (5-2410): 1.41e-35: 152: 10.59
+	Hs
		974083 ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00		DYST_HUMAN (5-2410): 1.41e-35: 152: 10.59
+	Hs
		1068630 Q96D37_HUMAN (2-60): 8.82e-15: 74.6: 42.37		PLEC_HUMAN (16-1253): 4.4e-31: 137: 9.18
+	Hs
		548710 VAV_HUMAN (2-60): 8.95e-15: 74.6: 42.37		PLEC_HUMAN (16-1253): 4.4e-31: 137: 9.18