HitPredict

Interactor 1: E9PGW7 (E9PGW7)
Mediator of RNA polymerase II transcription subunit 22 (Mediator complex subunit 22) (Surfeit locus protein 5)
Gene: MED22

Interactor 2: CDK8 (P49336)
Cyclin-dependent kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 8) (Mediator complex subunit CDK8) (Mediator of RNA polymerase II transcription subunit CDK8) (Protein kinase K35)
Gene: CDK8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	26496610
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0016592 - mediator complex
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 111 Hs			1 464
+	Hs
		826279 MED22_HUMAN (1-111): 4.36e-51: 161: 100.00		CDK8_HUMAN (1-464): 6.01e-167: 480: 100.00
+	Hs
		1074726 MED22_HUMAN (1-111): 4.36e-51: 161: 100.00		CDK19_HUMAN (1-464): 1.35e-144: 424: 75.90
+	Hs
		73028 MED22_HUMAN (1-111): 4.36e-51: 161: 100.00		B4DUB1_HUMAN (152-464): 5.46e-111: 334: 69.52