HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: CD2AP (Q9Y5K6)
CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains)
Gene: CD2AP

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.76 1.00 0.875

The method score is based on:

Property Details
Experiments 19380743, 21706016, 21988832
Identification Methods affinity chromatography technology, two hybrid, tandem affinity purification, two hybrid array, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains SH2~SH3_1, SH3_1~SH3_1
Common GO terms GO:0005737 - cytoplasm
GO:0005886 - plasma membrane
GO:0007165 - signal transduction
GO:0017124 - SH3 domain binding
GO:0070062 - extracellular exosome
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 217
Hs

1 639
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024