HitPredict

Interactor 1: IF4E (P63073)
Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (mRNA cap-binding protein) (eIF-4F 25 kDa subunit)
Gene: Eif4e

Interactor 2: 4EBP2 (P70445)
Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2) (Phosphorylated heat- and acid-stable protein regulated by insulin 2) (PHAS-II)
Gene: Eif4ebp2

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.912

Property	Details
Experiments	20347422, 8939971, 23263185, 17689282
Identification Methods	affinity chromatography technology, far western blotting, pull down, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	IF4E~eIF_4EBP
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0098794 - postsynapse
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 217 Mm			1 120
+	Hs
		416983 IF4E_HUMAN (1-217): 2.08e-109: 314: 98.16		4EBP2_HUMAN (1-120): 4.73e-62: 186: 95.00
+	Rn
		926380 IF4E_RAT (1-217): 4.96e-110: 316: 100.00		4EBP1_RAT (4-120): 2.3e-52: 162: 59.32
+	Hs
		416982 IF4E_HUMAN (1-217): 2.08e-109: 314: 98.16		4EBP1_HUMAN (4-120): 3.56e-51: 159: 57.98
+	Mm
		926370 IF4E_MOUSE (1-217): 4.96e-110: 316: 100.00		4EBP1_MOUSE (4-120): 2.15e-49: 154: 59.32
+	Hs
		237212 IF4E2_HUMAN (7-216): 4.41e-89: 264: 29.86		4EBP2_HUMAN (1-120): 4.73e-62: 186: 95.00
+	Hs
		64108 I4E1B_HUMAN (37-217): 1.62e-95: 280: 74.03		4EBP1_HUMAN (4-120): 3.56e-51: 159: 57.98
+	Hs
		236380 IF4E_HUMAN (1-217): 2.08e-109: 314: 98.16		4EBP3_HUMAN (29-120): 6.76e-34: 114: 57.61
+	Hs
		237211 IF4E2_HUMAN (7-216): 4.41e-89: 264: 29.86		4EBP1_HUMAN (4-120): 3.56e-51: 159: 57.98
+	Mm
		1141831 IF4E2_MOUSE (7-216): 4.28e-88: 261: 29.41		4EBP1_MOUSE (4-120): 2.15e-49: 154: 59.32
+	Dm
		820469 IF4E_DROME (4-217): 2.71e-98: 287: 47.47		4EBP_DROME (1-120): 2.6e-34: 116: 38.02
+	Dm
		1373363 Q9VRY0_DROME (6-217): 1.92e-94: 276: 45.16		4EBP_DROME (1-120): 2.6e-34: 116: 38.02
+	Dm
		1376673 Q9W5B3_DROME (36-217): 2.71e-87: 265: 48.90		4EBP_DROME (1-120): 2.6e-34: 116: 38.02
+	Hs
		236378 IF4E2_HUMAN (7-216): 4.41e-89: 264: 29.86		4EBP3_HUMAN (29-120): 6.76e-34: 114: 57.61
+	Dm
		1373550 Q9VSB6_DROME (16-217): 7.8e-87: 257: 42.37		4EBP_DROME (1-120): 2.6e-34: 116: 38.02
+	Dm
		1373609 Q9VSG1_DROME (17-217): 2.7e-84: 251: 39.41		4EBP_DROME (1-120): 2.6e-34: 116: 38.02