HitPredict

Interactor 1: SUMO1 (P63165)
Small ubiquitin-related modifier 1 (SUMO-1) (GAP-modifying protein 1) (GMP1) (SMT3 homolog 3) (Sentrin) (Ubiquitin-homology domain protein PIC1) (Ubiquitin-like protein SMT3C) (Smt3C) (Ubiquitin-like protein UBL1)
Gene: SUMO1

Interactor 2: SENP1 (Q9P0U3)
Sentrin-specific protease 1 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP1)
Gene: SENP1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	1.00	0.978

Property	Details
Experiments	16553580, 17000875, 16608850, 22878415, 30082317, 32296183, 17099698, unassigned1304, 15896780
Identification Methods	enzymatic study, pull down, two hybrid, x-ray crystallography, fluorescent resonance energy transfer, isothermal titration calorimetry, two hybrid prey pooling approach, two hybrid array, coimmunoprecipitation, validated two hybrid and 1 others more... cross-linking study
Interaction Type	direct interaction, association, physical association, cleavage reaction

Property	Details
Interacting Pfam domains	Peptidase_C48~Rad60-SLD
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016925 - protein sumoylation GO:0031965 - nuclear membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 101 Hs			1 644
+	Hs
		902778 SUMO2_HUMAN (1-97): 1.77e-38: 125: 45.36		SENP1_HUMAN (1-644): 0: 672: 100.00
+	Hs
		879158 SUMO3_HUMAN (1-97): 1.65e-37: 123: 47.42		SENP1_HUMAN (1-644): 0: 672: 100.00
+	Xl
		1125459 SMO1B_XENLA (1-101): 2.81e-39: 127: 93.14		Q804S7_XENLA (56-644): 1.26e-170: 502: 57.05
+	Xl
		1151579 SMO2B_XENLA (1-98): 6.18e-38: 124: 44.90		Q804S7_XENLA (56-644): 1.26e-170: 502: 57.05
+	Hs
		928203 SUMO1_HUMAN (1-101): 1.01e-41: 134: 100.00		SENP2_HUMAN (139-644): 1.28e-144: 434: 33.46
+	Hs
		902760 SUMO2_HUMAN (1-97): 1.77e-38: 125: 45.36		SENP2_HUMAN (139-644): 1.28e-144: 434: 33.46
+	Hs
		879156 SUMO3_HUMAN (1-97): 1.65e-37: 123: 47.42		SENP2_HUMAN (139-644): 1.28e-144: 434: 33.46
+	Xl
		78631 SMO2B_XENLA (1-98): 6.18e-38: 124: 44.90		B6RQN8_XENLA (17-644): 2.39e-141: 430: 21.02
+	Sp
		140841 PMT3_SCHPO (2-99): 1.41e-36: 121: 51.02		ULP1_SCHPO (36-643): 2.71e-120: 371: 23.86
+	Hs
		902753 SUMO2_HUMAN (1-97): 1.77e-38: 125: 45.36		SENP3_HUMAN (93-643): 1.85e-109: 343: 22.30
+	Hs
		902714 SUMO2_HUMAN (1-97): 1.77e-38: 125: 45.36		SENP5_HUMAN (172-644): 1.07e-102: 330: 23.01
+	Hs
		879147 SUMO3_HUMAN (1-97): 1.65e-37: 123: 47.42		SENP5_HUMAN (172-644): 1.07e-102: 330: 23.01
+	Xl
		1140103 SMO2B_XENLA (1-98): 6.18e-38: 124: 44.90		Q5XG28_XENLA (231-643): 1.01e-93: 298: 22.92
+	Sp
		140818 PMT3_SCHPO (2-99): 1.41e-36: 121: 51.02		ULP2_SCHPO (118-618): 5.31e-90: 294: 16.99
+	Hs
		902739 SUMO2_HUMAN (1-97): 1.77e-38: 125: 45.36		SENP7_HUMAN (386-643): 2.49e-47: 181: 17.38
+	Hs
		928190 SUMO1_HUMAN (1-101): 1.01e-41: 134: 100.00		SENP6_HUMAN (534-642): 8.6e-20: 96.2: 22.50
+	Mm
		1160381 SUMO3_MOUSE (1-100): 3.1e-40: 130: 46.00		SENP6_MOUSE (534-642): 1.31e-20: 98.9: 23.33
+	Xl
		80968 SMO2B_XENLA (1-98): 6.18e-38: 124: 44.90		B7TYL1_XENLA (534-642): 1.02e-20: 99.3: 23.33
+	Hs
		902747 SUMO2_HUMAN (1-97): 1.77e-38: 125: 45.36		SENP6_HUMAN (534-642): 8.6e-20: 96.2: 22.50
+	Xl
		80969 SMO2B_XENLA (1-98): 6.18e-38: 124: 44.90		B7TYL2_XENLA (542-643): 1.34e-13: 76.2: 21.24