HitPredict

Interactor 1: EPHA4 (P54764)
Ephrin type-A receptor 4 (EC 2.7.10.1) (EPH-like kinase 8) (EK8) (hEK8) (Tyrosine-protein kinase TYRO1) (Tyrosine-protein kinase receptor SEK)
Gene: EPHA4

Interactor 2: CEA21 (Q3KPI0)
Cell adhesion molecule CEACAM21 (Carcinoembryonic antigen-related cell adhesion molecule 21) (CEA cell adhesion molecule 21)
Gene: CEACAM21

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.80	0.770

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ephrin_lbd~V-set, Ig_3~fn3, V-set~fn3, SAM_2~V-set
Common GO terms	-
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 986 Hs			1 293
+	Hs
		710633 EPHA3_HUMAN (26-986): 0: 1171: 63.01		CEA21_HUMAN (1-293): 1.94e-71: 223: 100.00
+	Hs
		710503 EPHA2_HUMAN (27-986): 0: 1053: 50.67		ROBO2_HUMAN (3-250): 4.73e-41: 153: 16.54
+	Hs
		640181 EPHA1_HUMAN (17-974): 0: 965: 43.83		CEA21_HUMAN (1-293): 1.94e-71: 223: 100.00
+	Hs
		710600 EPHA2_HUMAN (27-986): 0: 1053: 50.67		ROBO1_HUMAN (138-282): 6.62e-22: 97.6: 16.56
+	Hs
		731832 EPHB4_HUMAN (14-977): 0: 1020: 49.90		CEAM8_HUMAN (12-260): 1.23e-19: 89.1: 14.62
+	Hs
		640241 EPHA1_HUMAN (17-974): 0: 965: 43.83		TITIN_HUMAN (152-259): 8.53e-09: 58.7: 16.22
+	Ce
		109605 VAB1_CAEEL (594-960): 8.33e-117: 386: 43.86		SAX3_CAEEL (145-292): 1.2e-22: 99.9: 15.63
+	Hs
		557335 SRC_HUMAN (601-871): 2.15e-64: 229: 45.42		CEA21_HUMAN (1-293): 1.94e-71: 223: 100.00
+	Hs
		440349 FYN_HUMAN (615-879): 2.52e-66: 234: 44.20		VGFR1_HUMAN (40-240): 1.13e-13: 73.2: 15.42
+	Hs
		557323 SRC_HUMAN (601-871): 2.15e-64: 229: 45.42		MYLK_HUMAN (30-140): 1.84e-12: 69.5: 11.71