HitPredict

Interactor 1: NR1H2 (P55055)
Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear receptor NER) (Nuclear receptor subfamily 1 group H member 2) (Ubiquitously-expressed nuclear receptor)
Gene: NR1H2

Interactor 2: ING3 (Q9NXR8)
Inhibitor of growth protein 3 (p47ING3)
Gene: ING3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	15604093
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0008270 - zinc ion binding GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 460 Hs			1 418
+	Hs
		1095516 NR1H3_HUMAN (4-460): 6.57e-119: 356: 62.31		ING3_HUMAN (1-418): 1.65e-142: 414: 100.00
+	Hs
		397075 ESR1_HUMAN (3-459): 2.93e-103: 321: 21.06		ING3_HUMAN (1-418): 1.65e-142: 414: 100.00
+	Hs
		834071 HNF4A_HUMAN (39-456): 2.19e-103: 317: 22.67		ING3_HUMAN (1-418): 1.65e-142: 414: 100.00
+	Mm
		1222881 ERR2_MOUSE (10-459): 1.41e-99: 306: 19.96		ING3_MOUSE (1-418): 7.84e-145: 420: 94.06
+	Mm
		650048 RARB_MOUSE (11-460): 3.54e-109: 333: 27.78		ING4_MOUSE (2-181): 3.76e-44: 155: 23.81
+	Hs
		396837 ESR1_HUMAN (3-459): 2.93e-103: 321: 21.06		DIDO1_HUMAN (110-410): 3.67e-40: 155: 14.74
+	Xl
		581938 THAA_XENLA (61-460): 3.82e-99: 305: 26.62		Q3L6P2_XENLA (3-155): 8.53e-42: 150: 21.80
+	Hs
		397179 ESR1_HUMAN (3-459): 2.93e-103: 321: 21.06		ING1_HUMAN (33-162): 1.97e-30: 123: 16.30
+	Hs
		834085 HNF4A_HUMAN (39-456): 2.19e-103: 317: 22.67		ING1_HUMAN (33-162): 1.97e-30: 123: 16.30
+	Hs
		833965 HNF4A_HUMAN (39-456): 2.19e-103: 317: 22.67		TAF3_HUMAN (324-407): 1.1e-17: 87.4: 24.72
+	Hs
		834073 HNF4A_HUMAN (39-456): 2.19e-103: 317: 22.67		CXXC1_HUMAN (340-418): 1.04e-17: 87.4: 28.24