Protein: CXXC1
CXXC-type zinc finger protein 1 (CpG-binding protein) (PHD finger and CXXC domain-containing protein 1)

Gene: CXXC1
Organism: Homo sapiens
Interactions: 123
UniProt ID: Q9P0U4

Gene Ontology (top 5):
GO:0000987 - cis-regulatory region sequence-specific DNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0006355 - regulation of DNA-templated transcription

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

175937

SET1A
Histone-lysine N-methyltransferase SETD1A

18

19

Small-scale

0.986

High

1454063

SET1B
Histone-lysine N-methyltransferase SETD1B

11

19

Small-scale

0.975

High

1067781

EP300
Histone acetyltransferase p300

1

18

Small-scale

0.770

High

965292

WDR5
WD repeat-containing protein 5

17

17

Small-scale

0.763

High

1454054

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

16

14

Small-scale

0.762

High

1145547

RBBP5
Retinoblastoma-binding protein 5

15

20

Small-scale

0.761

High

161518

KMT2D
Histone-lysine N-methyltransferase 2D

2

20

Small-scale

0.754

High

1041610

KMT2A
Histone-lysine N-methyltransferase 2A

2

19

Small-scale

0.754

High

1250051

WDR82
WD repeat-containing protein 82

7

20

Small-scale

0.742

High

1338709

BD1L1
Biorientation of chromosomes in cell division protein 1-like 1

6

6

High-throughput

0.732

High

1394243

BOD1
Biorientation of chromosomes in cell division protein 1

5

3

High-throughput

0.716

High

1420468

DPY30
Protein dpy-30 homolog

5

5

Small-scale

0.716

High

903270

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

11

High-throughput

0.698

High

419246

H2A1B
Histone H2A type 1-B/E

1

11

High-throughput

0.691

High

591866

H2AX
Histone H2AX

1

14

High-throughput

0.691

High

1162912

H2A2C
Histone H2A type 2-C

1

11

High-throughput

0.691

High

1413568

H2AJ
Histone H2A.J

1

11

High-throughput

0.691

High

1290994

TAXB1
Tax1-binding protein 1

3

9

High-throughput

0.675

High

610493

PRS6A
26S proteasome regulatory subunit 6A

3

1

High-throughput

0.667

High

1454058

NUP50
Nuclear pore complex protein Nup50

3

1

High-throughput

0.667

High

1454065

HCFC2
Host cell factor 2

3

13

High-throughput

0.667

High

905503

HCFC1
Host cell factor 1

3

13

Small-scale

0.662

High

414750

P53
Cellular tumor antigen p53

2

4

Small-scale

0.650

High

186086

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

3

6

Small-scale

0.650

High

938140

ANM2
Protein arginine N-methyltransferase 2

3

0

High-throughput

0.638

High

954632

PRPS1
Ribose-phosphate pyrophosphokinase 1

3

0

High-throughput

0.638

High

1110579

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

2

1

High-throughput

0.628

High

1439288

E41L5
Band 4.1-like protein 5

2

3

High-throughput

0.628

High

194620

KDM6A
Lysine-specific demethylase 6A

1

11

High-throughput

0.618

High

685078

DNMT1
DNA

1

7

Small-scale

0.618

High

981149

H2B1C
Histone H2B type 1-C/E/F/G/I

1

20

High-throughput

0.618

High

1119615

NFYC
Nuclear transcription factor Y subunit gamma

1

1

High-throughput

0.618

High

1258963

H32
Histone H3.2

1

20

Small-scale

0.618

High

1338279

KMT2C
Histone-lysine N-methyltransferase 2C

1

20

High-throughput

0.618

High

1454052

RERE
Arginine-glutamic acid dipeptide repeats protein

1

16

High-throughput

0.618

High

1454062

KMT2B
Histone-lysine N-methyltransferase 2B

1

19

High-throughput

0.618

High

1404813

RING2
E3 ubiquitin-protein ligase RING2

2

20

High-throughput

0.611

High

1369315

EDA
Ectodysplasin-A

3

2

High-throughput

0.609

High

139624

PESC
Pescadillo homolog

2

0

High-throughput

0.602

High

640626

MK
Midkine

2

0

High-throughput

0.602

High

872040

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

2

0

High-throughput

0.602

High

1219061

RSBN1
Lysine-specific demethylase 9

2

0

High-throughput

0.602

High

1437006

ZN408
Zinc finger protein 408

2

0

High-throughput

0.602

High

1433645

E41L1
Band 4.1-like protein 1

2

3

High-throughput

0.601

High

1454055

DAXX
Death domain-associated protein 6

2

1

High-throughput

0.601

High

129500

MEN1
Menin

2

6

Small-scale

0.584

High

373360

MYC
Myc proto-oncogene protein

2

16

High-throughput

0.584

High

980457

H4
Histone H4

2

12

Small-scale

0.584

High

951881

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

4

High-throughput

0.582

High

894215

MEOX2
Homeobox protein MOX-2

1

2

High-throughput

0.573

High

1101148

STF1
Steroidogenic factor 1

1

20

High-throughput

0.541

High

347378

BAG2
BAG family molecular chaperone regulator 2

1

1

High-throughput

0.536

High

854355

KI67
Proliferation marker protein Ki-67

1

5

High-throughput

0.536

High

961229

FGF12
Fibroblast growth factor 12

1

1

High-throughput

0.536

High

1099799

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

3

High-throughput

0.536

High

1228217

CR3L3
Cyclic AMP-responsive element-binding protein 3-like protein 3

1

5

High-throughput

0.536

High

1335353

ZN784
Zinc finger protein 784

1

2

High-throughput

0.536

High

1366139

DYRK2
Dual specificity tyrosine-phosphorylation-regulated kinase 2

1

8

High-throughput

0.536

High

1370588

FGF11
Fibroblast growth factor 11

1

1

High-throughput

0.536

High

1432476

E41LB
Band 4.1-like protein 4B

1

3

High-throughput

0.536

High

1454061

ABT1
Activator of basal transcription 1

1

1

High-throughput

0.536

High

1454064

E41L3
Band 4.1-like protein 3

1

3

High-throughput

0.536

High

341869

K2C75
Keratin, type II cytoskeletal 75

1

0

High-throughput

0.513

High

1022688

ZXDB
Zinc finger X-linked protein ZXDB

1

0

High-throughput

0.513

High

1454053

IKBL1
NF-kappa-B inhibitor-like protein 1

1

0

High-throughput

0.513

High

628852

TBP
TATA-box-binding protein

1

1

High-throughput

0.508

High

572961

INSRR
Insulin receptor-related protein

1

2

High-throughput

0.489

High

1290417

LRRT4
Leucine-rich repeat transmembrane neuronal protein 4

1

1

High-throughput

0.489

High

1402728

TCPQM
T-complex protein 1 subunit theta-like 2

1

2

High-throughput

0.489

High

968009

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

0

Small-scale

0.486

High

71479

P20L1
PHD finger protein 20-like protein 1

1

7

High-throughput

0.479

High

224381

BUB3
Mitotic checkpoint protein BUB3

1

18

High-throughput

0.479

High

272514

OBSL1
Obscurin-like protein 1

1

3

High-throughput

0.479

High

284891

TADA3
Transcriptional adapter 3

1

2

High-throughput

0.479

High

461990

HS90A
Heat shock protein HSP 90-alpha

1

4

High-throughput

0.479

High

468860

HS90B
Heat shock protein HSP 90-beta

1

4

High-throughput

0.479

High

519427

MYB
Transcriptional activator Myb

1

7

High-throughput

0.479

High

675707

TYY1
Transcriptional repressor protein YY1

1

6

High-throughput

0.479

High

739039

ELF1
ETS-related transcription factor Elf-1

1

20

High-throughput

0.479

High

834073

HNF4A
Hepatocyte nuclear factor 4-alpha

1

20

High-throughput

0.479

High

905224

MECP2
Methyl-CpG-binding protein 2

1

11

High-throughput

0.479

High

916052

NUP98
Nuclear pore complex protein Nup98-Nup96

1

4

High-throughput

0.479

High

928357

ATN1
Atrophin-1

1

19

High-throughput

0.479

High

961872

RL37A
Large ribosomal subunit protein eL43

1

2

High-throughput

0.479

High

1045853

TF65
Transcription factor p65

1

9

High-throughput

0.479

High

1130604

NCOA6
Nuclear receptor coactivator 6

1

7

High-throughput

0.479

High

1133702

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

1152752

ELF2
ETS-related transcription factor Elf-2

1

20

High-throughput

0.479

High

1154016

SMAD1
Mothers against decapentaplegic homolog 1

1

5

Small-scale

0.479

High

1220855

RN123
E3 ubiquitin-protein ligase RNF123

1

10

High-throughput

0.479

High

1255882

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.479

High

1257153

PAXI1
PAX-interacting protein 1

1

11

High-throughput

0.479

High

1276113

KANL1
KAT8 regulatory NSL complex subunit 1

1

3

High-throughput

0.479

High

1315063

ZZZ3
ZZ-type zinc finger-containing protein 3

1

2

High-throughput

0.479

High

1371142

IRF7
Interferon regulatory factor 7

1

3

Small-scale

0.479

High

1390176

MCRS1
Microspherule protein 1

1

3

High-throughput

0.479

High

1405446

FEV
Protein FEV

1

20

High-throughput

0.479

High

1405645

ELF4
ETS-related transcription factor Elf-4

1

20

High-throughput

0.479

High

1410393

MEP50
Methylosome protein WDR77

1

17

Small-scale

0.479

High

1415296

PHF20
PHD finger protein 20

1

12

High-throughput

0.479

High

1415820

KIFC1
Kinesin-like protein KIFC1

1

1

Small-scale

0.479

High

1435957

KAT8
Histone acetyltransferase KAT8

1

7

High-throughput

0.479

High

1436234

CSR2B
Cysteine-rich protein 2-binding protein

1

11

High-throughput

0.479

High

1437160

KANL2
KAT8 regulatory NSL complex subunit 2

1

3

High-throughput

0.479

High

1449148

MBIP1
MAP3K12-binding inhibitory protein 1

1

2

High-throughput

0.479

High

1454051

KANL3
KAT8 regulatory NSL complex subunit 3

1

3

High-throughput

0.479

High

1454056

ZRAN1
Ubiquitin thioesterase ZRANB1

1

9

High-throughput

0.479

High

1454057

XPO7
Exportin-7

1

4

High-throughput

0.479

High

1454059

ZN608
Zinc finger protein 608

1

4

High-throughput

0.479

High

1454060

YETS2
YEATS domain-containing protein 2

1

14

High-throughput

0.479

High

65198

A6NEM2
Host cell factor 1

1

13

High-throughput

0.445

High

231646

PRKY
Putative serine/threonine-protein kinase PRKY

1

2

High-throughput

0.445

High

530485

TAU
Microtubule-associated protein tau

1

11

High-throughput

0.445

High

1054152

BTK
Tyrosine-protein kinase BTK

1

8

High-throughput

0.445

High

1234992

PKHA7
Pleckstrin homology domain-containing family A member 7

1

15

High-throughput

0.445

High

106770

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

1326827

T11L2
T-complex protein 11-like protein 2

2

0

High-throughput

0.316

High

317754

NOL4
Nucleolar protein 4

1

0

High-throughput

0.279

Low

942010

NDK5
Nucleoside diphosphate kinase homolog 5

1

0

High-throughput

0.279

Low

1311042

SULF2
Extracellular sulfatase Sulf-2

1

0

High-throughput

0.279

Low

1325095

PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

1

0

High-throughput

0.279

Low

1428720

CHST5
Carbohydrate sulfotransferase 5

1

0

High-throughput

0.279

Low

516134

CT456
Cancer/testis antigen family 45 member A6

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025