HitPredict

Interactor 1: CSK21 (P68400)
Casein kinase II subunit alpha (CK II alpha) (EC 2.7.11.1)
Gene: CSNK2A1

Interactor 2: RING1 (Q06587)
E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Really interesting new gene 1 protein)
Gene: RING1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.90	0.60	0.738

Property	Details
Experiments	27705803, 25852190, 33961781, 35271311, 32707033, 36736316
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 391 Hs			1 406
+	Hs
		987994 CSK23_HUMAN (1-391): 5.89e-133: 388: 98.47		RING1_HUMAN (1-406): 2.01e-114: 342: 100.00
+	Hs
		934417 CSK21_HUMAN (1-391): 2.89e-136: 396: 100.00		RING2_HUMAN (8-406): 4.9e-100: 302: 54.25
+	Mm
		1141316 CSK21_MOUSE (1-391): 4.08e-134: 390: 98.72		RING2_MOUSE (8-406): 2.94e-100: 303: 54.25
+	Mm
		1142258 Q61177_MOUSE (1-391): 1.81e-133: 389: 98.47		RING2_MOUSE (8-406): 2.94e-100: 303: 54.25
+	Hs
		1243548 CSK23_HUMAN (1-391): 5.89e-133: 388: 98.47		RING2_HUMAN (8-406): 4.9e-100: 302: 54.25
+	Mm
		222427 CSK22_MOUSE (1-334): 4.23e-119: 351: 85.08		RING2_MOUSE (8-406): 2.94e-100: 303: 54.25
+	Hs
		717679 CSK21_HUMAN (1-391): 2.89e-136: 396: 100.00		BMI1_HUMAN (31-378): 4.06e-63: 207: 14.16
+	Hs
		625171 CDK2_HUMAN (36-330): 5.34e-122: 356: 29.74		BMI1_HUMAN (31-378): 4.06e-63: 207: 14.16
+	Hs
		718389 CSK21_HUMAN (1-391): 2.89e-136: 396: 100.00		PCGF2_HUMAN (31-377): 1.44e-41: 151: 14.37
+	Hs
		934449 CSK21_HUMAN (1-391): 2.89e-136: 396: 100.00		PCGF6_HUMAN (31-157): 1.02e-40: 149: 23.08
+	Hs
		934433 CSK21_HUMAN (1-391): 2.89e-136: 396: 100.00		PCGF1_HUMAN (25-133): 3.54e-40: 145: 25.00
+	Hs
		934208 CSK21_HUMAN (1-391): 2.89e-136: 396: 100.00		PCGF3_HUMAN (34-224): 6.2e-39: 141: 17.53
+	Hs
		749362 CSK21_HUMAN (1-391): 2.89e-136: 396: 100.00		BRCA1_HUMAN (33-361): 4.24e-35: 139: 15.63
+	Hs
		934279 CSK21_HUMAN (1-391): 2.89e-136: 396: 100.00		PCGF5_HUMAN (31-147): 4.96e-38: 139: 23.33
+	Hs
		1108520 CSK23_HUMAN (1-391): 5.89e-133: 388: 98.47		PCGF3_HUMAN (34-224): 6.2e-39: 141: 17.53
+	Hs
		1197573 CSK23_HUMAN (1-391): 5.89e-133: 388: 98.47		PCGF5_HUMAN (31-147): 4.96e-38: 139: 23.33
+	Dm
		437099 CSK2A_DROME (6-338): 3.31e-130: 378: 87.09		Q9VV77_DROME (33-129): 1.77e-37: 137: 27.00
+	Hs
		584875 CDK2_HUMAN (36-330): 5.34e-122: 356: 29.74		RO52_HUMAN (33-392): 4.67e-43: 158: 13.14
+	Hs
		625577 CDK2_HUMAN (36-330): 5.34e-122: 356: 29.74		BARD1_HUMAN (4-335): 2.56e-39: 151: 13.35
+	Hs
		625183 CDK2_HUMAN (36-330): 5.34e-122: 356: 29.74		BRCA1_HUMAN (33-361): 4.24e-35: 139: 15.63