HitPredict

Interactor 1: HDAC2 (P70288)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-) (YY1 transcription factor-binding protein)
Gene: HDAC2

Interactor 2: Q6AXH7 (Q6AXH7)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356)
Gene: Ezh2

Species: Mus musculus

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.39	0.60	0.484

Property	Details
Experiments	23624931
Identification Methods	anti bait coimmunoprecipitation, pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0035098 - ESC/E(Z) complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 488 Mm			1 742
+	Hs
		1080187 HDAC2_HUMAN (1-488): 0: 707: 99.39		EZH2_HUMAN (1-742): 0: 910: 96.41
+	Mm
		140274 HDAC1_MOUSE (1-446): 0: 647: 89.46		EZH2_MOUSE (1-742): 0: 918: 98.00
+	Hs
		1038412 HDAC1_HUMAN (1-446): 0: 643: 89.24		EZH2_HUMAN (1-742): 0: 910: 96.41
+	Dm
		785632 HDAC1_DROME (5-472): 0: 654: 77.71		EZ_DROME (8-741): 0: 779: 53.22
+	Hs
		1270450 HDAC2_HUMAN (1-488): 0: 707: 99.39		EHMT1_HUMAN (430-728): 5.9e-72: 257: 23.51
+	Hs
		975297 HDAC2_HUMAN (1-488): 0: 707: 99.39		KMT2A_HUMAN (243-729): 1.42e-70: 254: 18.13
+	Hs
		203750 HDAC2_HUMAN (1-488): 0: 707: 99.39		SUV91_HUMAN (417-727): 3.33e-76: 253: 22.63
+	Mm
		222461 HDAC2_MOUSE (1-488): 0: 706: 100.00		SUV91_MOUSE (417-727): 3.98e-75: 250: 22.32
+	Hs
		1270381 HDAC2_HUMAN (1-488): 0: 707: 99.39		EHMT2_HUMAN (430-728): 1.13e-66: 241: 24.14
+	Hs
		331858 HDAC2_HUMAN (1-488): 0: 707: 99.39		NSD2_HUMAN (551-723): 2.46e-55: 208: 30.56
+	Hs
		1038721 HDAC1_HUMAN (1-446): 0: 643: 89.24		EHMT1_HUMAN (430-728): 5.9e-72: 257: 23.51
+	Mm
		140205 HDAC1_MOUSE (1-446): 0: 647: 89.46		SUV91_MOUSE (417-727): 3.98e-75: 250: 22.32
+	Hs
		975244 HDAC1_HUMAN (1-446): 0: 643: 89.24		KMT2A_HUMAN (243-729): 1.42e-70: 254: 18.13
+	Hs
		203679 HDAC1_HUMAN (1-446): 0: 643: 89.24		SUV91_HUMAN (417-727): 3.33e-76: 253: 22.63
+	Hs
		1038631 HDAC1_HUMAN (1-446): 0: 643: 89.24		EHMT2_HUMAN (430-728): 1.13e-66: 241: 24.14
+	Mm
		140296 HDAC1_MOUSE (1-446): 0: 647: 89.46		NSD2_MOUSE (551-723): 5.13e-56: 210: 31.11
+	Hs
		331809 HDAC1_HUMAN (1-446): 0: 643: 89.24		NSD2_HUMAN (551-723): 2.46e-55: 208: 30.56
+	Hs
		177134 HDAC3_HUMAN (10-431): 0: 575: 58.02		SUV91_HUMAN (417-727): 3.33e-76: 253: 22.63
+	Mm
		222457 HDAC3_MOUSE (10-431): 0: 575: 58.26		SUV91_MOUSE (417-727): 3.98e-75: 250: 22.32
+	Hs
		1038822 HDAC1_HUMAN (1-446): 0: 643: 89.24		KMT2B_HUMAN (602-729): 2.48e-17: 89.4: 39.54