HitPredict

Interactor 1: SEC13 (P55735)
Protein SEC13 homolog (GATOR2 complex protein SEC13) (SEC13-like protein 1) (SEC13-related protein)
Gene: SEC13

Interactor 2: GRWD1 (Q9BQ67)
Glutamate-rich WD repeat-containing protein 1
Gene: GRWD1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CAF1C_H4-bd~WD40, WD40~WD40
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 322 Hs			1 446
+	Hs
		1291942 WDR5B_HUMAN (2-194): 2.54e-31: 121: 16.67		GRWD1_HUMAN (1-446): 1.7e-119: 357: 100.00
+	Hs
		965194 WDR5_HUMAN (2-194): 1.15e-30: 119: 16.67		GRWD1_HUMAN (1-446): 1.7e-119: 357: 100.00
+	Hs
		1387524 SNR40_HUMAN (3-131): 2.14e-24: 103: 22.22		GRWD1_HUMAN (1-446): 1.7e-119: 357: 100.00
+	Hs
		938199 SEC13_HUMAN (1-322): 2.24e-85: 261: 100.00		WDR5_HUMAN (248-445): 1.74e-47: 167: 21.72
+	At
		1247477 TAF5_ARATH (7-281): 1.14e-36: 141: 21.60		TAF5_ARATH (148-445): 3.37e-61: 212: 19.93
+	Hs
		938231 SEC13_HUMAN (1-322): 2.24e-85: 261: 100.00		WDR59_HUMAN (259-382): 1.25e-12: 72: 28.23
+	Hs
		965141 FBXW7_HUMAN (87-316): 1.16e-41: 155: 14.72		WDR5_HUMAN (248-445): 1.74e-47: 167: 21.72
+	Hs
		965071 WDR5B_HUMAN (2-194): 2.54e-31: 121: 16.67		WDR5_HUMAN (248-445): 1.74e-47: 167: 21.72
+	Hs
		964797 WDR5_HUMAN (2-194): 1.15e-30: 119: 16.67		WDR5_HUMAN (248-445): 1.74e-47: 167: 21.72
+	Hs
		845264 WDR5_HUMAN (2-194): 1.15e-30: 119: 16.67		LIS1_HUMAN (257-445): 1.64e-41: 153: 17.60
+	Hs
		965151 SNR40_HUMAN (3-131): 2.14e-24: 103: 22.22		WDR5_HUMAN (248-445): 1.74e-47: 167: 21.72
+	Hs
		1158951 FBXW7_HUMAN (87-316): 1.16e-41: 155: 14.72		RBBP7_HUMAN (66-247): 3.47e-20: 94.2: 10.42
+	Dm
		1463899 WDS_DROME (2-198): 7.68e-32: 123: 17.33		WDS_DROME (295-445): 5.51e-31: 124: 15.23
+	Ce
		1018718 SEC13_CAEEL (102-321): 3.48e-31: 121: 21.59		LIN53_CAEEL (41-247): 1.43e-20: 95.4: 10.33
+	Hs
		964891 WDR5_HUMAN (2-194): 1.15e-30: 119: 16.67		RBBP4_HUMAN (66-247): 7.51e-20: 93.1: 10.42
+	Hs
		965276 WDR5_HUMAN (2-194): 1.15e-30: 119: 16.67		NLE1_HUMAN (338-445): 3.35e-17: 85.8: 13.89
+	Hs
		1450936 NLE1_HUMAN (196-317): 8.5e-28: 114: 20.49		NLE1_HUMAN (338-445): 3.35e-17: 85.8: 13.89
+	Hs
		1149764 TAF5_HUMAN (171-320): 4.86e-23: 101: 14.61		TAF5_HUMAN (297-445): 1.33e-19: 93.5: 11.44
+	Hs
		965034 WDR5_HUMAN (2-194): 1.15e-30: 119: 16.67		WDR59_HUMAN (259-382): 1.25e-12: 72: 28.23