HitPredict

Interactor 1: EPS8 (F1M3L7)
Epidermal growth factor receptor kinase substrate 8
Gene: EPS8

Interactor 2: INSR (P15127)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Species: Rattus norvegicus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	30300385
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 822 Rn			1 1383
+	Hs
		665590 EPS8_HUMAN (1-822): 0: 980: 90.39		EPHB2_HUMAN (662-1317): 0: 577: 23.01
+	Hs
		1020370 EPS8_HUMAN (1-822): 0: 980: 90.39		NTRK3_HUMAN (997-1291): 5.26e-62: 230: 38.80
+	Hs
		338351 EPS8_HUMAN (1-822): 0: 980: 90.39		EGFR_HUMAN (32-308): 1.21e-29: 130: 22.50
+	Hs
		872470 STAM1_HUMAN (384-783): 2.91e-47: 178: 14.42		EPHA5_HUMAN (662-1320): 0: 581: 24.11
+	Hs
		433265 YES_HUMAN (456-690): 7.58e-46: 174: 11.95		EPHB2_HUMAN (662-1317): 0: 577: 23.01
+	Mm
		763386 FYN_MOUSE (456-785): 3.44e-46: 175: 14.49		EPHA4_MOUSE (662-1328): 0: 572: 24.49
+	Hs
		665508 STAM1_HUMAN (384-783): 2.91e-47: 178: 14.42		EPHA8_HUMAN (663-1323): 1.14e-174: 548: 22.59
+	Hs
		665303 STAM1_HUMAN (384-783): 2.91e-47: 178: 14.42		EPHA2_HUMAN (662-1321): 2.76e-167: 528: 22.70
+	Hs
		385279 STAM1_HUMAN (384-783): 2.91e-47: 178: 14.42		NTRK1_HUMAN (997-1287): 1.6e-65: 240: 41.95
+	Hs
		1081556 STAM1_HUMAN (384-783): 2.91e-47: 178: 14.42		NTRK3_HUMAN (997-1291): 5.26e-62: 230: 38.80
+	Hs
		609455 STAM1_HUMAN (384-783): 2.91e-47: 178: 14.42		FGFR3_HUMAN (1016-1288): 2.88e-60: 224: 40.07
+	Hs
		433253 YES_HUMAN (456-690): 7.58e-46: 174: 11.95		ERBB3_HUMAN (5-368): 5.74e-31: 135: 19.70
+	Hs
		442779 HCK_HUMAN (462-688): 1.3e-45: 173: 12.24		ERBB3_HUMAN (5-368): 5.74e-31: 135: 19.70
+	Hs
		337789 YES_HUMAN (456-690): 7.58e-46: 174: 11.95		EGFR_HUMAN (32-308): 1.21e-29: 130: 22.50
+	Hs
		337804 HCK_HUMAN (462-688): 1.3e-45: 173: 12.24		EGFR_HUMAN (32-308): 1.21e-29: 130: 22.50
+	Hs
		433359 YES_HUMAN (456-690): 7.58e-46: 174: 11.95		ERBB4_HUMAN (44-347): 2.97e-26: 119: 20.42
+	Hs
		442833 HCK_HUMAN (462-688): 1.3e-45: 173: 12.24		ERBB4_HUMAN (44-347): 2.97e-26: 119: 20.42
+	Hs
		383538 YES_HUMAN (456-690): 7.58e-46: 174: 11.95		ERBB2_HUMAN (32-342): 4.75e-18: 92.8: 19.83
+	Hs
		383529 FYN_HUMAN (456-785): 2.42e-45: 173: 14.21		ERBB2_HUMAN (32-342): 4.75e-18: 92.8: 19.83
+	Hs
		383547 HCK_HUMAN (462-688): 1.3e-45: 173: 12.24		ERBB2_HUMAN (32-342): 4.75e-18: 92.8: 19.83