Protein: WNK4
Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase lysine-deficient 4) (Protein kinase with no lysine 4)

Gene: WNK4
Organism: Homo sapiens
Interactions: 25
UniProt ID: Q96J92

Gene Ontology (top 5):
GO:0002021 - response to dietary excess
GO:0003096 - renal sodium ion transport
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

343633

OXSR1
Serine/threonine-protein kinase OSR1

2

19

Small-scale

0.799

High

1394709

KLHL3
Kelch-like protein 3

11

10

Small-scale

0.758

High

1394706

WNK1
Serine/threonine-protein kinase WNK1

2

18

Small-scale

0.754

High

122969

SGK1
Serine/threonine-protein kinase Sgk1

1

17

Small-scale

0.724

High

832767

BCL6
B-cell lymphoma 6 protein

1

1

Small-scale

0.691

High

728387

AKT1
RAC-alpha serine/threonine-protein kinase

1

17

Small-scale

0.647

High

1114002

CUL3
Cullin-3

3

12

Small-scale

0.640

High

329092

KLHL2
Kelch-like protein 2

2

10

Small-scale

0.633

High

1394708

STK39
STE20/SPS1-related proline-alanine-rich protein kinase

1

19

Small-scale

0.621

High

461815

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

468691

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

1394710

AFF4
AF4/FMR2 family member 4

1

2

High-throughput

0.553

High

481363

HMGB1
High mobility group protein B1

1

5

Small-scale

0.508

High

1394705

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

18

Small-scale

0.501

High

691336

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

730827

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

971880

1433E
14-3-3 protein epsilon

1

17

High-throughput

0.479

High

1272721

MAEA
E3 ubiquitin-protein transferase MAEA

1

6

Small-scale

0.479

High

1370296

CSN5
COP9 signalosome complex subunit 5

1

4

Small-scale

0.479

High

1394707

RMD5A
E3 ubiquitin-protein transferase RMND5A

1

6

Small-scale

0.479

High

1338320

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

990605

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.445

High

1367024

ESR2
Estrogen receptor beta

1

11

High-throughput

0.445

High

845241

GDF5
Growth/differentiation factor 5

1

1

High-throughput

0.437

High

1392030

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025