Protein: WNK2
Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43)

Gene: WNK2
Organism: Homo sapiens
Interactions: 36
UniProt ID: Q9Y3S1

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1433327

WNK1
Serine/threonine-protein kinase WNK1

2

18

High-throughput

0.817

High

343662

OXSR1
Serine/threonine-protein kinase OSR1

2

19

High-throughput

0.799

High

1178801

AAK1
AP2-associated protein kinase 1

1

19

High-throughput

0.691

High

1418966

WNK3
Serine/threonine-protein kinase WNK3

1

17

High-throughput

0.691

High

1491265

T22D4
TSC22 domain family protein 4

3

17

High-throughput

0.667

High

122985

SGK1
Serine/threonine-protein kinase Sgk1

1

17

Small-scale

0.618

High

362422

ABL1
Tyrosine-protein kinase ABL1

1

15

High-throughput

0.618

High

440803

FYN
Tyrosine-protein kinase Fyn

1

15

High-throughput

0.618

High

995914

ACTC
Actin, alpha cardiac muscle 1

1

5

High-throughput

0.618

High

1324118

RHG24
Rho GTPase-activating protein 24

1

9

High-throughput

0.618

High

990909

1433Z
14-3-3 protein zeta/delta

2

20

High-throughput

0.614

High

1049941

1433F
14-3-3 protein eta

2

20

High-throughput

0.601

High

1459689

KLHL3
Kelch-like protein 3

2

12

Small-scale

0.584

High

255316

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

17

High-throughput

0.575

High

682660

S100P
Protein S100-P

1

8

High-throughput

0.536

High

972169

1433E
14-3-3 protein epsilon

1

19

High-throughput

0.536

High

1383901

EFMT3
EEF1A lysine methyltransferase 3

1

5

High-throughput

0.536

High

1130230

SMC1A
Structural maintenance of chromosomes protein 1A

1

8

High-throughput

0.515

High

927627

ATX1
Ataxin-1

1

3

High-throughput

0.508

High

1219202

SPAT1
Spermatogenesis-associated protein 1

1

1

High-throughput

0.489

High

160923

STX16
Syntaxin-16

1

3

High-throughput

0.479

High

329124

KLHL2
Kelch-like protein 2

1

12

Small-scale

0.479

High

483273

CLCA
Clathrin light chain A

1

7

High-throughput

0.479

High

610516

PRS6A
26S proteasome regulatory subunit 6A

1

10

High-throughput

0.479

High

942977

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

9

High-throughput

0.479

High

984346

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

5

High-throughput

0.479

High

1114729

CUL3
Cullin-3

1

15

High-throughput

0.479

High

1388667

SPDLY
Protein Spindly

1

17

High-throughput

0.479

High

1058375

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1363280

ASM3B
Acid sphingomyelinase-like phosphodiesterase 3b

1

0

High-throughput

0.458

High

993826

UBC9
SUMO-conjugating enzyme UBC9

1

7

High-throughput

0.457

High

173598

XPO1
Exportin-1

1

18

High-throughput

0.445

High

1199767

KLH22
Kelch-like protein 22

1

13

High-throughput

0.445

High

1277014

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

8

High-throughput

0.437

High

1333427

S43A3
Equilibrative nucleobase transporter 1

1

0

High-throughput

0.269

Low

1387429

ESS2
Splicing factor ESS-2 homolog

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025