HitPredict

Interactor 1: TCPB (P78371)
T-complex protein 1 subunit beta (TCP-1-beta) (CCT-beta) (Chaperonin containing T-complex polypeptide 1 subunit 2)
Gene: CCT2

Interactor 2: FBXW8 (Q8N3Y1)
F-box/WD repeat-containing protein 8 (F-box and WD-40 domain-containing protein 8) (F-box only protein 29)
Gene: FBXW8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	33961781, 37689310, 21572988
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 535 Hs			1 598
+	Hs
		1232692 TCPH_HUMAN (4-532): 0: 591: 34.08		FBXW8_HUMAN (1-598): 4.17e-132: 400: 96.17
+	Hs
		943393 TCPB_HUMAN (1-535): 0: 586: 100.00		FBXW7_HUMAN (285-590): 1.43e-81: 272: 13.88
+	Hs
		1198554 TCPH_HUMAN (4-532): 0: 591: 34.08		WDR86_HUMAN (64-420): 1.44e-55: 194: 13.30
+	Hs
		943324 TCPB_HUMAN (1-535): 0: 586: 100.00		WDR86_HUMAN (64-420): 1.44e-55: 194: 13.30
+	Hs
		1202777 TCPH_HUMAN (4-532): 0: 591: 34.08		WDR5B_HUMAN (40-372): 8.51e-54: 188: 13.41
+	Hs
		1306645 TCPH_HUMAN (4-532): 0: 591: 34.08		TBL1Y_HUMAN (329-589): 8.89e-51: 185: 11.93
+	Hs
		943328 TCPB_HUMAN (1-535): 0: 586: 100.00		WDR5B_HUMAN (40-372): 8.51e-54: 188: 13.41
+	Hs
		943437 TCPB_HUMAN (1-535): 0: 586: 100.00		TBL1Y_HUMAN (329-589): 8.89e-51: 185: 11.93
+	Hs
		1306704 TCPH_HUMAN (4-532): 0: 591: 34.08		NLE1_HUMAN (374-598): 6.99e-46: 170: 10.26
+	Hs
		943508 TCPB_HUMAN (1-535): 0: 586: 100.00		NLE1_HUMAN (374-598): 6.99e-46: 170: 10.26
+	Hs
		943370 TCPB_HUMAN (1-535): 0: 586: 100.00		POC1B_HUMAN (428-590): 8.43e-39: 150: 15.39
+	Hs
		792942 TCPG_HUMAN (3-532): 0: 561: 28.33		LIS1_HUMAN (6-327): 3.89e-44: 164: 11.60
+	Hs
		1306744 TCPH_HUMAN (4-532): 0: 591: 34.08		FBW1A_HUMAN (421-593): 2.84e-31: 130: 17.22
+	Hs
		943546 TCPB_HUMAN (1-535): 0: 586: 100.00		FBW1A_HUMAN (421-593): 2.84e-31: 130: 17.22
+	Hs
		903467 TCPH_HUMAN (4-532): 0: 591: 34.08		WDR5_HUMAN (463-590): 7.6e-28: 116: 12.69
+	Hs
		903120 TCPB_HUMAN (1-535): 0: 586: 100.00		WDR5_HUMAN (463-590): 7.6e-28: 116: 12.69
+	Hs
		826601 TCPG_HUMAN (3-532): 0: 561: 28.33		WDR5_HUMAN (463-590): 7.6e-28: 116: 12.69
+	Hs
		1240450 TCPH_HUMAN (4-532): 0: 591: 34.08		POC1A_HUMAN (71-262): 1.3e-15: 81.1: 9.95
+	Hs
		943355 TCPB_HUMAN (1-535): 0: 586: 100.00		POC1A_HUMAN (71-262): 1.3e-15: 81.1: 9.95
+	Sc
		760642 TCPB_YEAST (9-532): 0: 566: 65.71		MDV1_YEAST (379-508): 4.29e-13: 74.4: 19.46