HitPredict

Interactor 1: DLGP1 (P97836)
Disks large-associated protein 1 (DAP-1) (Guanylate kinase-associated protein) (rGKAP) (PSD-95/SAP90-binding protein 1) (SAP90/PSD-95-associated protein 1) (SAPAP1)
Gene: Dlgap1

Interactor 2: SHAN1 (Q9WV48)
SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (GKAP/SAPAP-interacting protein) (SPANK-1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP) (Synamon)
Gene: Shank1

Species: Rattus norvegicus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.76 1.00 0.874

The method score is based on:

Property Details
Experiments 10433268, 11178875, 10488079
Identification Methods two hybrid, affinity chromatography technology, anti bait coimmunoprecipitation, pull down, coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains GKAP~PDZ_6
Common GO terms GO:0005886 - plasma membrane
GO:0014069 - postsynaptic density
GO:0035418 - protein localization to synapse
GO:0044877 - protein-containing complex binding
GO:0045202 - synapse
and 4 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 992
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1 2167
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024