HitPredict

Interactor 1: SHC2 (P98077)
SHC-transforming protein 2 (Protein Sck) (SHC-transforming protein B) (Src homology 2 domain-containing-transforming protein C2) (SH2 domain protein C2)
Gene: SHC2

Interactor 2: AP1B1 (Q10567)
AP-1 complex subunit beta-1 (Adaptor protein complex AP-1 subunit beta-1) (Adaptor-related protein complex 1 subunit beta-1) (Beta-1-adaptin) (Beta-adaptin 1) (Clathrin assembly protein complex 1 beta large chain) (Golgi adaptor HA1/AP1 adaptin beta subunit)
Gene: AP1B1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 582 Hs			1 949
+	Hs
		666090 SHC1_HUMAN (1-581): 2.34e-124: 379: 45.41		AP1B1_HUMAN (1-949): 0: 978: 100.00
+	Hs
		666058 SHC1_HUMAN (1-581): 2.34e-124: 379: 45.41		AP2B1_HUMAN (1-949): 0: 944: 81.45
+	Hs
		925962 ANS1A_HUMAN (34-384): 4.52e-50: 188: 14.91		AP2B1_HUMAN (1-949): 0: 944: 81.45
+	Hs
		321527 SHC2_HUMAN (1-582): 9.32e-153: 453: 100.00		AP2A1_HUMAN (12-943): 0: 677: 18.58
+	Hs
		1014028 ARH_HUMAN (106-424): 2.81e-36: 139: 16.02		AP1B1_HUMAN (1-949): 0: 978: 100.00
+	Hs
		925893 ARH_HUMAN (106-424): 2.81e-36: 139: 16.02		AP2B1_HUMAN (1-949): 0: 944: 81.45
+	Hs
		321492 SHC1_HUMAN (1-581): 2.34e-124: 379: 45.41		AP2A1_HUMAN (12-943): 0: 677: 18.58
+	Mm
		193241 GRB2_MOUSE (475-582): 4.98e-16: 79.1: 27.68		AP1B1_MOUSE (1-949): 0: 950: 95.89
+	Hs
		924449 GRB2_HUMAN (475-582): 5.69e-16: 79.1: 28.07		AP2B1_HUMAN (1-949): 0: 944: 81.45
+	Hs
		302103 SHC1_HUMAN (1-581): 2.34e-124: 379: 45.41		AP2A2_HUMAN (12-945): 0: 625: 18.33
+	Ce
		283753 CED6_CAEEL (93-497): 1.43e-45: 169: 17.48		Q9N4F3_CAEEL (1-947): 0: 819: 63.06
+	Mm
		567529 ANS1B_MOUSE (26-366): 5.11e-50: 188: 14.01		AP2A2_MOUSE (12-945): 0: 634: 17.94
+	Hs
		321464 LCK_HUMAN (321-582): 1.49e-36: 144: 14.60		AP2A1_HUMAN (12-943): 0: 677: 18.58
+	Hs
		321522 GRB2_HUMAN (475-582): 5.69e-16: 79.1: 28.07		AP2A1_HUMAN (12-943): 0: 677: 18.58
+	Mm
		729767 BTK_MOUSE (281-581): 1.14e-37: 149: 13.29		AP3B1_MOUSE (6-612): 0: 569: 28.44
+	Hs
		302130 GRB2_HUMAN (475-582): 5.69e-16: 79.1: 28.07		AP2A2_HUMAN (12-945): 0: 625: 18.33
+	Ce
		283751 CED6_CAEEL (93-497): 1.43e-45: 169: 17.48		Q22601_CAEEL (14-746): 1.07e-157: 489: 18.58