HitPredict

Interactor 1: MAX (P61244)
Protein max (Class D basic helix-loop-helix protein 4) (bHLHd4) (Myc-associated factor X)
Gene: MAX

Interactor 2: MAD4 (Q14582)
Max dimerization protein 4 (Max dimerizer 4) (Class C basic helix-loop-helix protein 12) (bHLHc12) (Max-associated protein 4) (Max-interacting transcriptional repressor MAD4)
Gene: MXD4

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.93 1.00 0.965

The method score is based on:

Property Details
Experiments 10593926, 25609649, 29028833, 27705803, 9528857, 33961781, 10229200
Identification Methods two hybrid, affinity chromatography technology, pull down, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains HLH~HLH
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0005654 - nucleoplasm
GO:0006357 - regulation of transcription by RNA polymerase II
and 1 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 160
Hs

1 209
+ Hs
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+ Gg
+ Rn
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+ Mm
+ Hs
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+ Mm

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Last updated: 11Aug2025