HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: NECT3 (Q9NQS3)
Nectin-3 (CDw113) (Nectin cell adhesion molecule 3) (Poliovirus receptor-related protein 3) (CD antigen CD113)
Gene: NECTIN3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~V-set
Common GO terms	GO:0005886 - plasma membrane GO:0043296 - apical junction complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 549
+	Hs
		988739 RAC1_HUMAN (1-193): 7e-79: 235: 57.22		NECT3_HUMAN (49-549): 5e-106: 330: 100.00
+	Hs
		466480 RHOC_HUMAN (1-193): 1.75e-77: 231: 91.71		NECT3_HUMAN (49-549): 5e-106: 330: 100.00
+	Hs
		1015824 RHOG_HUMAN (1-193): 1.49e-76: 229: 54.40		NECT3_HUMAN (49-549): 5e-106: 330: 100.00
+	Hs
		962384 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		KIRR1_HUMAN (41-509): 1.63e-61: 217: 17.59
+	Hs
		962340 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		NECT2_HUMAN (25-360): 1.23e-62: 216: 28.81
+	Hs
		988611 RAC1_HUMAN (1-193): 7e-79: 235: 57.22		KIRR1_HUMAN (41-509): 1.63e-61: 217: 17.59
+	Hs
		988582 RAC1_HUMAN (1-193): 7e-79: 235: 57.22		NECT2_HUMAN (25-360): 1.23e-62: 216: 28.81
+	Hs
		466411 RHOC_HUMAN (1-193): 1.75e-77: 231: 91.71		KIRR1_HUMAN (41-509): 1.63e-61: 217: 17.59
+	Hs
		466392 RHOC_HUMAN (1-193): 1.75e-77: 231: 91.71		NECT2_HUMAN (25-360): 1.23e-62: 216: 28.81
+	Hs
		1015683 RHOG_HUMAN (1-193): 1.49e-76: 229: 54.40		KIRR1_HUMAN (41-509): 1.63e-61: 217: 17.59
+	Hs
		1015648 RHOG_HUMAN (1-193): 1.49e-76: 229: 54.40		NECT2_HUMAN (25-360): 1.23e-62: 216: 28.81
+	Hs
		955477 CDC42_HUMAN (1-193): 4.17e-76: 228: 52.33		KIRR1_HUMAN (41-509): 1.63e-61: 217: 17.59
+	Hs
		955440 CDC42_HUMAN (1-193): 4.17e-76: 228: 52.33		NECT2_HUMAN (25-360): 1.23e-62: 216: 28.81
+	Hs
		962213 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		SDK1_HUMAN (5-475): 9.15e-33: 136: 14.80
+	Hs
		955439 CDC42_HUMAN (1-193): 4.17e-76: 228: 52.33		PXDN_HUMAN (246-547): 7.53e-34: 139: 11.54
+	Hs
		962694 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		ROBO1_HUMAN (264-548): 4.82e-21: 99.8: 10.98
+	Hs
		988870 RAC1_HUMAN (1-193): 7e-79: 235: 57.22		ROBO1_HUMAN (264-548): 4.82e-21: 99.8: 10.98
+	Hs
		466555 RHOC_HUMAN (1-193): 1.75e-77: 231: 91.71		ROBO1_HUMAN (264-548): 4.82e-21: 99.8: 10.98
+	Ce
		145082 RAC1_CAEEL (1-193): 1.28e-79: 236: 55.44		UNC89_CAEEL (69-289): 5.16e-12: 71.3: 8.60
+	Ce
		110130 G5EBV3_CAEEL (2-193): 4.38e-77: 230: 50.52		UNC89_CAEEL (69-289): 5.16e-12: 71.3: 8.60