HitPredict

Interactor 1: SUMO2 (P61956)
Small ubiquitin-related modifier 2 (SUMO-2) (HSMT3) (SMT3 homolog 2) (SUMO-3) (Sentrin-2) (Ubiquitin-like protein SMT3B) (Smt3B)
Gene: SUMO2

Interactor 2: ZMIZ2 (Q8NF64)
Zinc finger MIZ domain-containing protein 2 (PIAS-like protein Zimp7)
Gene: ZMIZ2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	37531430
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Rad60-SLD~zf-MIZ
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016925 - protein sumoylation GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 95 Hs			1 920
+	Rn
		93350 SUMO3_RAT (1-94): 2.05e-42: 135: 95.75		D4AE97_RAT (3-920): 7.58e-111: 368: 55.85
+	At
		1228125 SUMO2_ARATH (3-93): 5.6e-38: 124: 51.65		SIZ1_ARATH (372-920): 5e-106: 351: 18.44
+	At
		1228124 SUMO3_ARATH (1-94): 1.61e-36: 120: 40.43		SIZ1_ARATH (372-920): 5e-106: 351: 18.44
+	At
		939035 SUMO1_ARATH (1-91): 8.65e-36: 118: 47.25		SIZ1_ARATH (372-920): 5e-106: 351: 18.44
+	Hs
		964366 SUMO2_HUMAN (1-95): 3.58e-44: 139: 100.00		PIAS4_HUMAN (361-717): 6.56e-74: 253: 23.32
+	Hs
		297541 SUMO2_HUMAN (1-95): 3.58e-44: 139: 100.00		PIAS1_HUMAN (351-815): 1.41e-71: 251: 18.88
+	Hs
		939211 SUMO3_HUMAN (1-94): 3.78e-41: 132: 96.81		PIAS4_HUMAN (361-717): 6.56e-74: 253: 23.32
+	Hs
		297530 SUMO3_HUMAN (1-94): 3.78e-41: 132: 96.81		PIAS1_HUMAN (351-815): 1.41e-71: 251: 18.88
+	Rn
		1220400 SUMO3_RAT (1-94): 2.05e-42: 135: 95.75		PIAS2_RAT (356-791): 4.43e-71: 247: 23.40
+	Rn
		81598 SUMO3_RAT (1-94): 2.05e-42: 135: 95.75		B5DFF9_RAT (361-717): 5.58e-70: 243: 22.78
+	Hs
		297781 SUMO2_HUMAN (1-95): 3.58e-44: 139: 100.00		PIAS2_HUMAN (356-801): 4.6e-67: 238: 22.92
+	Hs
		297778 SUMO3_HUMAN (1-94): 3.78e-41: 132: 96.81		PIAS2_HUMAN (356-801): 4.6e-67: 238: 22.92
+	Hs
		991365 SUMO1_HUMAN (1-93): 7.79e-35: 116: 45.36		PIAS4_HUMAN (361-717): 6.56e-74: 253: 23.32
+	Hs
		297561 SUMO1_HUMAN (1-93): 7.79e-35: 116: 45.36		PIAS1_HUMAN (351-815): 1.41e-71: 251: 18.88
+	Dm
		356490 O97102_DROME (1-94): 1.25e-37: 123: 68.09		Q9XYM5_DROME (341-797): 1.61e-68: 239: 19.63
+	Hs
		297784 SUMO1_HUMAN (1-93): 7.79e-35: 116: 45.36		PIAS2_HUMAN (356-801): 4.6e-67: 238: 22.92
+	Hs
		964529 SUMO2_HUMAN (1-95): 3.58e-44: 139: 100.00		PIAS3_HUMAN (360-861): 2.42e-54: 201: 18.68
+	Hs
		939243 SUMO3_HUMAN (1-94): 3.78e-41: 132: 96.81		PIAS3_HUMAN (360-861): 2.42e-54: 201: 18.68
+	Mm
		236336 SUMO1_MOUSE (1-93): 7.79e-35: 116: 45.36		PIAS3_MOUSE (360-861): 2e-55: 205: 19.04
+	Hs
		991472 SUMO1_HUMAN (1-93): 7.79e-35: 116: 45.36		PIAS3_HUMAN (360-861): 2.42e-54: 201: 18.68