HitPredict

Interactor 1: DCAF7 (P61962)
DDB1- and CUL4-associated factor 7 (WD repeat-containing protein 68) (WD repeat-containing protein An11 homolog)
Gene: DCAF7

Interactor 2: AMRA1 (Q9C0C7)
Activating molecule in BECN1-regulated autophagy protein 1 (DDB1- and CUL4-associated factor 3)
Gene: AMBRA1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	27173435, 30166453
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	WD40~WD40
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0080008 - Cul4-RING E3 ubiquitin ligase complex
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 342 Hs			1 1298
+	Hs
		323858 SC31A_HUMAN (23-342): 4.06e-56: 198: 17.26		WDR5_HUMAN (3-297): 1.09e-86: 287: 18.39
+	Hs
		845264 LIS1_HUMAN (153-340): 1.08e-36: 138: 12.23		WDR5_HUMAN (3-297): 1.09e-86: 287: 18.39
+	Ce
		1018728 LIN53_CAEEL (10-342): 7.02e-69: 223: 14.63		LIS1_CAEEL (39-337): 1.1e-49: 183: 13.38
+	Hs
		964797 WDR5_HUMAN (208-342): 1.41e-28: 114: 11.85		WDR5_HUMAN (3-297): 1.09e-86: 287: 18.39
+	Hs
		965194 GRWD1_HUMAN (125-326): 1.98e-23: 102: 22.62		WDR5_HUMAN (3-297): 1.09e-86: 287: 18.39
+	At
		201140 TTG1_ARATH (5-342): 2.04e-73: 232: 50.43		GBLPA_ARATH (1-123): 2.81e-16: 83.7: 20.13
+	Hs
		965071 WDR5_HUMAN (208-342): 1.41e-28: 114: 11.85		WDR5B_HUMAN (4-207): 3.21e-55: 197: 14.68
+	Hs
		965151 WDR5_HUMAN (208-342): 1.41e-28: 114: 11.85		SNR40_HUMAN (45-334): 1.8e-54: 196: 12.04
+	Hs
		1291942 GRWD1_HUMAN (125-326): 1.98e-23: 102: 22.62		WDR5B_HUMAN (4-207): 3.21e-55: 197: 14.68
+	Hs
		1387524 GRWD1_HUMAN (125-326): 1.98e-23: 102: 22.62		SNR40_HUMAN (45-334): 1.8e-54: 196: 12.04
+	Hs
		845250 LIS1_HUMAN (153-340): 1.08e-36: 138: 12.23		LIS1_HUMAN (123-363): 2.02e-35: 142: 12.30
+	Mm
		988931 LIS1_MOUSE (153-340): 9.14e-37: 138: 12.23		LIS1_MOUSE (123-363): 1.82e-35: 142: 12.30
+	Sp
		1068486 TUP11_SCHPO (1-253): 3.09e-46: 167: 14.57		TUP12_SCHPO (171-368): 7.07e-13: 75.3: 9.81
+	Hs
		845346 LIS1_HUMAN (153-340): 1.08e-36: 138: 12.23		KTNB1_HUMAN (167-610): 4.74e-17: 88.7: 8.64
+	Dm
		1463899 WDS_DROME (208-342): 4.59e-27: 111: 9.63		WDS_DROME (174-342): 1.41e-22: 102: 10.53
+	Hs
		965141 WDR5_HUMAN (208-342): 1.41e-28: 114: 11.85		FBXW7_HUMAN (164-314): 4.21e-18: 92.2: 10.53
+	Hs
		1334151 POC1A_HUMAN (2-204): 3.35e-28: 114: 18.72		POC1B_HUMAN (1-83): 2.36e-16: 85.7: 16.28