HitPredict

Interactor 1: AT2B2 (Q01814)
Plasma membrane calcium-transporting ATPase 2 (PMCA2) (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 2) (Plasma membrane calcium pump isoform 2)
Gene: ATP2B2

Interactor 2: LPAR4 (Q99677)
Lysophosphatidic acid receptor 4 (LPA receptor 4) (LPA-4) (G-protein coupled receptor 23) (P2Y purinoceptor 9) (P2Y9) (P2Y5-like receptor) (Purinergic receptor 9)
Gene: LPAR4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0043231 - intracellular membrane-bounded organelle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1243 Hs			1 370
+	Hs
		895608 AT2B2_HUMAN (1-1243): 0: 1285: 100.00		CXCR4_HUMAN (31-319): 1.02e-85: 265: 29.11
+	Hs
		781053 AT2B2_HUMAN (1-1243): 0: 1285: 100.00		OPRX_HUMAN (5-364): 7e-70: 225: 22.87
+	Hs
		208453 AT2B2_HUMAN (1-1243): 0: 1285: 100.00		OX2R_HUMAN (10-360): 1.15e-67: 221: 17.96
+	Hs
		849665 AT2B2_HUMAN (1-1243): 0: 1285: 100.00		CCR6_HUMAN (7-366): 1.76e-67: 219: 23.84
+	Hs
		895636 AT2B3_HUMAN (1-1243): 0: 1209: 80.67		CXCR4_HUMAN (31-319): 1.02e-85: 265: 29.11
+	Hs
		782425 AT2B3_HUMAN (1-1243): 0: 1209: 80.67		P2RY2_HUMAN (31-317): 2.76e-83: 259: 32.76
+	Hs
		966830 AT2B2_HUMAN (1-1243): 0: 1285: 100.00		P2RY8_HUMAN (45-319): 9.58e-48: 167: 36.84
+	Hs
		588553 AT2B1_HUMAN (1-1243): 0: 1186: 78.86		P2RY2_HUMAN (31-317): 2.76e-83: 259: 32.76
+	Hs
		674851 AT2B3_HUMAN (1-1243): 0: 1209: 80.67		AGTR1_HUMAN (15-358): 1.57e-72: 231: 24.86
+	Hs
		781059 AT2B3_HUMAN (1-1243): 0: 1209: 80.67		OPRX_HUMAN (5-364): 7e-70: 225: 22.87
+	Hs
		208456 AT2B3_HUMAN (1-1243): 0: 1209: 80.67		OX2R_HUMAN (10-360): 1.15e-67: 221: 17.96
+	Hs
		588555 AT2B1_HUMAN (1-1243): 0: 1186: 78.86		CCR2_HUMAN (29-336): 1.9e-71: 229: 25.33
+	Hs
		619202 AT2B4_HUMAN (1-1243): 0: 1154: 68.56		AGTR1_HUMAN (15-358): 1.57e-72: 231: 24.86
+	Hs
		428921 AT2B4_HUMAN (1-1243): 0: 1154: 68.56		ADRB2_HUMAN (12-342): 4.86e-71: 229: 18.28
+	Hs
		1086542 AT2B3_HUMAN (1-1243): 0: 1209: 80.67		P2RY8_HUMAN (45-319): 9.58e-48: 167: 36.84
+	Hs
		208448 AT2B4_HUMAN (1-1243): 0: 1154: 68.56		OX2R_HUMAN (10-360): 1.15e-67: 221: 17.96
+	Hs
		588630 AT2B1_HUMAN (1-1243): 0: 1186: 78.86		P2RY8_HUMAN (45-319): 9.58e-48: 167: 36.84
+	Hs
		588565 AT2B1_HUMAN (1-1243): 0: 1186: 78.86		PAR2_HUMAN (45-319): 2.48e-40: 148: 32.86
+	Hs
		588604 AT2B1_HUMAN (1-1243): 0: 1186: 78.86		P2RY6_HUMAN (30-320): 9.19e-40: 145: 32.10
+	Hs
		126568 AT2B4_HUMAN (1-1243): 0: 1154: 68.56		P2Y10_HUMAN (25-319): 1.42e-46: 163: 34.34