HitPredict

Interactor 1: VASP (P50552)
Vasodilator-stimulated phosphoprotein (VASP)
Gene: VASP

Interactor 2: ZYX (Q15942)
Zyxin (Zyxin-2)
Gene: ZYX

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.967

Property	Details
Experiments	28514442, 32296183, 10882740, 34079125, 33961781, 10801818, unassigned1304
Identification Methods	affinity chromatography technology, two hybrid, proximity labelling technology, anti tag coimmunoprecipitation, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	LIM~WH1
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0015629 - actin cytoskeleton
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 380 Hs			1 572
+	Hs
		840600 VASP_HUMAN (1-380): 1.43e-91: 281: 100.00		LIMD1_HUMAN (1-571): 7.16e-66: 228: 22.80
+	Hs
		840535 VASP_HUMAN (1-380): 1.43e-91: 281: 100.00		FBLI1_HUMAN (252-572): 4.13e-67: 224: 29.61
+	Hs
		359 A0A075B6E5_HUMAN (1-159): 1.64e-69: 219: 52.20		ZYX_HUMAN (1-572): 1.68e-71: 241: 100.00
+	Hs
		1080810 EVL_HUMAN (1-375): 2.06e-60: 202: 43.68		ZYX_HUMAN (1-572): 1.68e-71: 241: 100.00
+	Hs
		1260462 EVL_HUMAN (1-375): 2.06e-60: 202: 43.68		FBLI1_HUMAN (252-572): 4.13e-67: 224: 29.61
+	Hs
		823356 VASP_HUMAN (1-380): 1.43e-91: 281: 100.00		PAXI_HUMAN (8-500): 3.72e-32: 132: 12.12
+	Dm
		1210945 ENA_DROME (2-235): 1.21e-41: 158: 36.33		Q8I0G8_DROME (276-572): 3.5e-75: 249: 37.37
+	Dm
		1137155 ENA_DROME (2-235): 1.21e-41: 158: 36.33		Q5U0W6_DROME (276-569): 8.42e-74: 246: 37.08
+	Hs
		840599 VASP_HUMAN (1-380): 1.43e-91: 281: 100.00		TES_HUMAN (345-499): 3.83e-20: 95.1: 17.28
+	Hs
		1191615 SPRE1_HUMAN (2-343): 2.84e-90: 280: 15.66		TES_HUMAN (345-499): 3.83e-20: 95.1: 17.28
+	Hs
		840541 VASP_HUMAN (1-380): 1.43e-91: 281: 100.00		LPP_HUMAN (4-495): 1.9e-13: 75.1: 13.92
+	Hs
		1080725 ENAH_HUMAN (109-379): 3.91e-23: 102: 30.06		ZYX_HUMAN (1-572): 1.68e-71: 241: 100.00
+	Hs
		1190444 SPRE1_HUMAN (2-343): 2.84e-90: 280: 15.66		LIMS2_HUMAN (384-544): 8.75e-10: 62.4: 27.55
+	Hs
		1237868 ENAH_HUMAN (109-379): 3.91e-23: 102: 30.06		FBLI1_HUMAN (252-572): 4.13e-67: 224: 29.61
+	Mm
		975400 ENAH_MOUSE (109-379): 3.12e-16: 82.4: 28.17		ZYX_MOUSE (1-572): 3.2e-62: 216: 85.02
+	Hs
		1355072 EVL_HUMAN (1-375): 2.06e-60: 202: 43.68		TES_HUMAN (345-499): 3.83e-20: 95.1: 17.28
+	Rn
		1101450 Q5XHX3_RAT (219-379): 4.03e-32: 128: 38.92		TES_RAT (294-571): 6.62e-27: 115: 15.36
+	Hs
		1237898 ENAH_HUMAN (109-379): 3.91e-23: 102: 30.06		TES_HUMAN (345-499): 3.83e-20: 95.1: 17.28
+	Hs
		1237872 ENAH_HUMAN (109-379): 3.91e-23: 102: 30.06		AJUBA_HUMAN (9-499): 2.93e-13: 74.3: 11.33