HitPredict

Interactor 1: 1433G (P61981)
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]
Gene: YWHAG

Interactor 2: M4K5 (Q9Y4K4)
Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (Kinase homologous to SPS1/STE20) (KHS) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5)
Gene: MAP4K5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36736316
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 247 Hs			1 846
+	Hs
		971849 1433E_HUMAN (1-244): 2.03e-141: 398: 63.53		M4K1_HUMAN (9-845): 0: 781: 44.52
+	Dm
		94942 1433E_DROME (1-243): 1.59e-140: 396: 63.37		E1JGN0_DROME (4-616): 4.08e-139: 443: 18.34
+	Hs
		971494 1433E_HUMAN (1-244): 2.03e-141: 398: 63.53		KCC2D_HUMAN (8-517): 1.12e-145: 440: 18.38
+	Hs
		971530 1433E_HUMAN (1-244): 2.03e-141: 398: 63.53		MELK_HUMAN (20-615): 4.56e-138: 426: 19.61
+	Hs
		692031 1433E_HUMAN (1-244): 2.03e-141: 398: 63.53		MARK3_HUMAN (13-559): 5.86e-136: 424: 18.88
+	Mm
		972206 1433E_MOUSE (1-244): 2.03e-141: 398: 63.53		MARK3_MOUSE (13-559): 1.34e-135: 423: 19.06
+	Hs
		972147 1433E_HUMAN (1-244): 2.03e-141: 398: 63.53		KCC2A_HUMAN (8-488): 1.45e-138: 421: 19.68
+	Hs
		692029 1433G_HUMAN (1-247): 3.17e-139: 392: 100.00		MARK3_HUMAN (13-559): 5.86e-136: 424: 18.88
+	Mm
		967095 1433G_MOUSE (1-247): 3.17e-139: 392: 100.00		MARK3_MOUSE (13-559): 1.34e-135: 423: 19.06
+	Hs
		728147 1433E_HUMAN (1-244): 2.03e-141: 398: 63.53		AKT1_HUMAN (1-347): 4.4e-130: 399: 22.47
+	Xl
		237423 O57468_XENLA (1-244): 4.27e-141: 397: 63.12		Q804T2_XENLA (17-489): 4.35e-126: 397: 21.01
+	Hs
		971697 1433E_HUMAN (1-244): 2.03e-141: 398: 63.53		MARK2_HUMAN (17-473): 1.36e-124: 395: 21.60
+	At
		1379653 14337_ARATH (3-244): 3.2e-142: 400: 60.25		CIPKC_ARATH (2-385): 1.02e-124: 385: 26.09
+	At
		840534 14333_ARATH (1-244): 4.42e-142: 400: 61.79		CIPKC_ARATH (2-385): 1.02e-124: 385: 26.09
+	At
		1030913 14332_ARATH (4-244): 1.4e-141: 398: 61.32		CIPKC_ARATH (2-385): 1.02e-124: 385: 26.09
+	Hs
		971464 1433E_HUMAN (1-244): 2.03e-141: 398: 63.53		STK4_HUMAN (10-278): 5.62e-120: 373: 45.93
+	Hs
		971474 1433E_HUMAN (1-244): 2.03e-141: 398: 63.53		STK3_HUMAN (1-408): 1.49e-119: 372: 32.45
+	Hs
		971777 1433E_HUMAN (1-244): 2.03e-141: 398: 63.53		MINK1_HUMAN (3-295): 3.14e-70: 254: 45.28
+	Hs
		348091 1433E_HUMAN (1-244): 2.03e-141: 398: 63.53		M4K4_HUMAN (2-295): 4.05e-64: 236: 43.51
+	Hs
		348088 1433G_HUMAN (1-247): 3.17e-139: 392: 100.00		M4K4_HUMAN (2-295): 4.05e-64: 236: 43.51