Protein: M4K1
Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (Hematopoietic progenitor kinase) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1)

Gene: M4K1, MAP4K1
Organism: Homo sapiens
Interactions: 126
UniProt ID: Q92918

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0006468 - protein phosphorylation
GO:0007254 - JNK cascade

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

461782

HS90A
Heat shock protein HSP 90-alpha

4

20

High-throughput

0.881

High

468664

HS90B
Heat shock protein HSP 90-beta

4

20

High-throughput

0.881

High

1370649

M4K1
Mitogen-activated protein kinase kinase kinase kinase 1

3

16

Small-scale

0.861

High

363672

EGFR
Epidermal growth factor receptor

3

20

High-throughput

0.843

High

995184

CSK2B
Casein kinase II subunit beta

2

3

High-throughput

0.789

High

619087

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

4

High-throughput

0.770

High

1159138

M3K11
Mitogen-activated protein kinase kinase kinase 11

2

9

Small-scale

0.757

High

987818

GRB2
Growth factor receptor-bound protein 2

8

20

Small-scale

0.753

High

362336

ABL1
Tyrosine-protein kinase ABL1

2

20

Small-scale

0.743

High

783634

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

2

18

High-throughput

0.737

High

594070

NCK1
SH2/SH3 adapter protein NCK1

6

20

Small-scale

0.727

High

855713

CRK
Adapter molecule crk

5

20

Small-scale

0.717

High

855916

CRKL
Crk-like protein

4

20

Small-scale

0.702

High

856844

BAG6
Large proline-rich protein BAG6

1

10

High-throughput

0.691

High

1107992

SQSTM
Sequestosome-1

1

9

High-throughput

0.691

High

1157845

DDB1
DNA damage-binding protein 1

1

1

High-throughput

0.691

High

1370652

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

5

High-throughput

0.691

High

1370673

NUDC
Nuclear migration protein nudC

4

4

High-throughput

0.683

High

213984

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

19

Small-scale

0.665

High

1312031

DJC10
DnaJ homolog subfamily C member 10

1

0

High-throughput

0.656

High

292858

GRAP2
GRB2-related adapter protein 2

2

20

Small-scale

0.644

High

952009

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

2

20

Small-scale

0.624

High

440662

FYN
Tyrosine-protein kinase Fyn

1

20

High-throughput

0.618

High

557415

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

High-throughput

0.618

High

1038677

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

10

High-throughput

0.618

High

1106024

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

9

High-throughput

0.618

High

1122534

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

19

Small-scale

0.618

High

1158460

CDC37
Hsp90 co-chaperone Cdc37

1

10

High-throughput

0.618

High

1182850

LRRK1
Leucine-rich repeat serine/threonine-protein kinase 1

1

10

High-throughput

0.618

High

1308469

VRK3
Serine/threonine-protein kinase VRK3

1

16

High-throughput

0.618

High

1370669

KBRS2
NF-kappa-B inhibitor-interacting Ras-like protein 2

1

18

High-throughput

0.618

High

1370670

TBK1
Serine/threonine-protein kinase TBK1

1

17

Small-scale

0.618

High

992286

SKP1
S-phase kinase-associated protein 1

2

3

Small-scale

0.584

High

1370663

CAR11
Caspase recruitment domain-containing protein 11

1

14

Small-scale

0.578

High

1098823

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

17

Small-scale

0.575

High

766744

PHB1
Prohibitin 1

2

3

High-throughput

0.571

High

767290

MERL
Merlin

2

13

High-throughput

0.571

High

953957

IF4A1
Eukaryotic initiation factor 4A-I

2

6

High-throughput

0.571

High

1357678

BLNK
B-cell linker protein

1

11

Small-scale

0.561

High

1370671

DBNL
Drebrin-like protein

1

16

Small-scale

0.561

High

627689

IF2B
Eukaryotic translation initiation factor 2 subunit 2

2

0

High-throughput

0.547

High

165065

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

1

High-throughput

0.536

High

243990

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

19

High-throughput

0.536

High

325964

UBR5
E3 ubiquitin-protein ligase UBR5

1

20

High-throughput

0.536

High

424442

HMGN1
Non-histone chromosomal protein HMG-14

1

1

High-throughput

0.536

High

610811

TCPA
T-complex protein 1 subunit alpha

1

17

High-throughput

0.536

High

697608

PYR1
Multifunctional protein CAD

1

5

High-throughput

0.536

High

723035

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

1

High-throughput

0.536

High

786196

LONM
Lon protease homolog, mitochondrial

1

7

High-throughput

0.536

High

821489

TCPZ
T-complex protein 1 subunit zeta

1

15

High-throughput

0.536

High

876101

TCPE
T-complex protein 1 subunit epsilon

1

19

High-throughput

0.536

High

882073

TCPG
T-complex protein 1 subunit gamma

1

19

High-throughput

0.536

High

899165

TCPQ
T-complex protein 1 subunit theta

1

20

High-throughput

0.536

High

899510

TCPD
T-complex protein 1 subunit delta

1

14

High-throughput

0.536

High

964698

DCAF7
DDB1- and CUL4-associated factor 7

1

4

High-throughput

0.536

High

1007183

TCPB
T-complex protein 1 subunit beta

1

20

High-throughput

0.536

High

1111469

IQGA2
Ras GTPase-activating-like protein IQGAP2

1

16

High-throughput

0.536

High

1365717

GCN1
Stalled ribosome sensor GCN1

1

20

High-throughput

0.536

High

1370270

CSN5
COP9 signalosome complex subunit 5

1

12

High-throughput

0.536

High

1370658

TCPH
T-complex protein 1 subunit eta

1

20

High-throughput

0.536

High

1370665

WDR6
tRNA

1

17

High-throughput

0.536

High

1370668

BCLF1
Bcl-2-associated transcription factor 1

1

8

High-throughput

0.536

High

1370675

TR150
Thyroid hormone receptor-associated protein 3

1

9

High-throughput

0.536

High

916316

TXTP
Tricarboxylate transport protein, mitochondrial

2

1

High-throughput

0.521

High

1370653

TM101
Transmembrane protein 101

1

0

High-throughput

0.518

High

361325

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.513

High

1370005

GSLG1
Golgi apparatus protein 1

1

0

High-throughput

0.513

High

1370654

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.513

High

1370657

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

0

High-throughput

0.513

High

994320

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

20

High-throughput

0.501

High

1370666

STRN4
Striatin-4

1

20

High-throughput

0.501

High

124429

HAX1
HCLS1-associated protein X-1

1

1

High-throughput

0.489

High

160571

IRS4
Insulin receptor substrate 4

1

4

High-throughput

0.489

High

471161

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

1

High-throughput

0.489

High

724145

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

3

High-throughput

0.489

High

1101293

SLAF1
Signaling lymphocytic activation molecule

1

9

Small-scale

0.489

High

220398

LAT
Linker for activation of T-cells family member 1

1

1

Small-scale

0.479

High

222169

NCK2
Cytoplasmic protein NCK2

1

20

High-throughput

0.479

High

345096

RIGI
Antiviral innate immune response receptor RIG-I

1

9

Small-scale

0.479

High

540064

BCR
Breakpoint cluster region protein

1

14

High-throughput

0.479

High

571683

HCLS1
Hematopoietic lineage cell-specific protein

1

20

Small-scale

0.479

High

666115

PPAC
Low molecular weight phosphotyrosine protein phosphatase

1

1

High-throughput

0.479

High

699819

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

10

High-throughput

0.479

High

730811

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

916697

PPP5
Serine/threonine-protein phosphatase 5

1

20

High-throughput

0.479

High

954565

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

1

High-throughput

0.479

High

971849

1433E
14-3-3 protein epsilon

1

15

High-throughput

0.479

High

983917

RBX1
E3 ubiquitin-protein ligase RBX1

1

1

Small-scale

0.479

High

985517

RL32
Large ribosomal subunit protein eL32

1

3

High-throughput

0.479

High

1045601

TF65
Transcription factor p65

1

7

Small-scale

0.479

High

1046398

UBXN1
UBX domain-containing protein 1

1

1

High-throughput

0.479

High

1129168

IRF3
Interferon regulatory factor 3

1

1

Small-scale

0.479

High

1135025

CUL7
Cullin-7

1

3

Small-scale

0.479

High

1150677

TRBP2
RISC-loading complex subunit TARBP2

1

5

High-throughput

0.479

High

1278054

MAVS
Mitochondrial antiviral-signaling protein

1

8

Small-scale

0.479

High

1325505

FBXW8
F-box/WD repeat-containing protein 8

1

16

Small-scale

0.479

High

1370650

FBXW7
F-box/WD repeat-containing protein 7

1

15

Small-scale

0.479

High

1370655

PARK7
Parkinson disease protein 7

1

1

High-throughput

0.479

High

1370659

PYM1
Partner of Y14 and mago

1

1

High-throughput

0.479

High

1370667

PIHD1
PIH1 domain-containing protein 1

1

2

High-throughput

0.479

High

1370672

VPS4A
Vacuolar protein sorting-associated protein 4A

1

6

High-throughput

0.479

High

1370674

DTX4
E3 ubiquitin-protein ligase DTX4

1

3

Small-scale

0.479

High

1370679

NEMO
NF-kappa-B essential modulator

1

20

Small-scale

0.479

High

1163114

H2B2E
Histone H2B type 2-E

1

13

High-throughput

0.470

High

1370677

CIA2B
Cytosolic iron-sulfur assembly component 2B

1

0

High-throughput

0.458

High

419120

H2A1B
Histone H2A type 1-B/E

1

1

Small-scale

0.457

High

839489

PI4KA
Phosphatidylinositol 4-kinase alpha

1

6

High-throughput

0.445

High

125966

SMAP
Small acidic protein

1

2

High-throughput

0.437

High

169682

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

6

High-throughput

0.437

High

731517

STIP1
Stress-induced-phosphoprotein 1

1

11

High-throughput

0.437

High

1141845

EEA1
Early endosome antigen 1

1

20

High-throughput

0.437

High

1144109

TEBP
Prostaglandin E synthase 3

1

3

High-throughput

0.437

High

1195675

Q4LE69
Phosphatidylinositol 4-kinase alpha

1

6

High-throughput

0.437

High

1370664

RPAP3
RNA polymerase II-associated protein 3

1

14

High-throughput

0.437

High

1370676

SGT1
Protein SGT1 homolog

1

15

High-throughput

0.437

High

1370678

RT16
Small ribosomal subunit protein bS16m

1

2

High-throughput

0.437

High

1370662

RPAP1
RNA polymerase II-associated protein 1

1

0

High-throughput

0.279

Low

221384

SPY1
Protein sprouty homolog 1

1

0

Small-scale

0.249

Low

1092709

AF1Q
Protein AF1q

1

0

High-throughput

0.249

Low

1162200

NDUA5
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5

1

0

High-throughput

0.249

Low

1278391

HDDC2
5'-deoxynucleotidase HDDC2

1

0

High-throughput

0.249

Low

1370651

MGN2
Protein mago nashi homolog 2

1

0

High-throughput

0.249

Low

1370656

METH
Methionine synthase

1

0

High-throughput

0.249

Low

1370660

HGH1
Protein HGH1 homolog

1

0

High-throughput

0.249

Low

1370661

THTPA
Thiamine-triphosphatase

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025