Protein: GRB10
Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR)

Gene: GRB10
Organism: Homo sapiens
Interactions: 163
UniProt ID: Q13322

Gene Ontology (top 5):
GO:0005158 - insulin receptor binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0008286 - insulin receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

411376

INSR
Insulin receptor

11

20

Small-scale

0.981

High

435632

IGF1R
Insulin-like growth factor 1 receptor

6

20

Small-scale

0.946

High

1031659

GRB10
Growth factor receptor-bound protein 10

5

20

Small-scale

0.921

High

338370

EGFR
Epidermal growth factor receptor

4

20

Small-scale

0.897

High

522961

SRC
Proto-oncogene tyrosine-protein kinase Src

3

20

Small-scale

0.861

High

374172

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

20

Small-scale

0.845

High

434186

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

2

20

Small-scale

0.840

High

1031676

WDR59
GATOR2 complex protein WDR59

2

7

High-throughput

0.811

High

789021

TXK
Tyrosine-protein kinase TXK

2

20

High-throughput

0.783

High

846466

BLK
Tyrosine-protein kinase Blk

2

18

High-throughput

0.783

High

1031660

TNK1
Non-receptor tyrosine-protein kinase TNK1

2

20

High-throughput

0.783

High

924543

GRB2
Growth factor receptor-bound protein 2

2

19

High-throughput

0.776

High

724541

IRS1
Insulin receptor substrate 1

2

20

Small-scale

0.768

High

1031726

BAIP2
BAR/IMD domain-containing adapter protein 2

2

11

High-throughput

0.767

High

681825

AKT1
RAC-alpha serine/threonine-protein kinase

1

20

Small-scale

0.757

High

655353

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

2

20

Small-scale

0.754

High

1031706

NED4L
E3 ubiquitin-protein ligase NEDD4-like

2

15

Small-scale

0.754

High

1031729

IRS2
Insulin receptor substrate 2

2

20

Small-scale

0.754

High

872612

EPHB1
Ephrin type-B receptor 1

1

20

Small-scale

0.751

High

499263

KIT
Mast/stem cell growth factor receptor Kit

1

20

Small-scale

0.740

High

972190

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

20

Small-scale

0.740

High

902899

DCAF7
DDB1- and CUL4-associated factor 7

2

4

High-throughput

0.737

High

1031708

GRWD1
Glutamate-rich WD repeat-containing protein 1

2

3

High-throughput

0.737

High

1031713

SKI8
Superkiller complex protein 8

2

3

High-throughput

0.737

High

1031715

WDR6
tRNA

2

12

High-throughput

0.737

High

904520

1433G
14-3-3 protein gamma

4

20

High-throughput

0.694

High

981977

1433F
14-3-3 protein eta

4

20

High-throughput

0.691

High

738204

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

20

Small-scale

0.690

High

909517

1433E
14-3-3 protein epsilon

3

6

Small-scale

0.674

High

1026152

PAK1
Serine/threonine-protein kinase PAK 1

1

20

High-throughput

0.665

High

264302

GGYF1
GRB10-interacting GYF protein 1

3

11

Small-scale

0.661

High

1031674

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

3

4

High-throughput

0.650

High

337461

ABL1
Tyrosine-protein kinase ABL1

1

20

Small-scale

0.647

High

383780

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.647

High

412177

FYN
Tyrosine-protein kinase Fyn

1

19

Small-scale

0.647

High

1031667

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.647

High

1031685

ABI1
Abl interactor 1

1

20

Small-scale

0.647

High

1031678

GGYF2
GRB10-interacting GYF protein 2

3

20

Small-scale

0.641

High

684014

1433S
14-3-3 protein sigma

3

20

High-throughput

0.633

High

729650

VGFR2
Vascular endothelial growth factor receptor 2

1

20

Small-scale

0.621

High

801118

KI67
Proliferation marker protein Ki-67

1

16

High-throughput

0.618

High

238405

JAK2
Tyrosine-protein kinase JAK2

1

20

Small-scale

0.618

High

348644

RASN
GTPase NRas

1

20

Small-scale

0.618

High

500963

GHR
Growth hormone receptor

1

20

Small-scale

0.618

High

1031671

NTRK2
BDNF/NT-3 growth factors receptor

1

20

Small-scale

0.618

High

1031679

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

1031720

HECW2
E3 ubiquitin-protein ligase HECW2

1

15

High-throughput

0.618

High

1031725

SHAN2
SH3 and multiple ankyrin repeat domains protein 2

1

18

Small-scale

0.618

High

1031721

RCAN3
Calcipressin-3

2

0

High-throughput

0.607

High

131429

IMA4
Importin subunit alpha-4

2

2

High-throughput

0.606

High

311920

SYFM
Phenylalanine--tRNA ligase, mitochondrial

2

2

High-throughput

0.606

High

1031673

KANK2
KN motif and ankyrin repeat domain-containing protein 2

2

16

High-throughput

0.606

High

1031704

AP4AT
AP-4 complex accessory subunit Tepsin

2

1

High-throughput

0.606

High

1031718

PICK1
PRKCA-binding protein

2

3

High-throughput

0.606

High

872640

EPHA4
Ephrin type-A receptor 4

1

20

High-throughput

0.590

High

1031670

SNAT
Serotonin N-acetyltransferase

2

0

High-throughput

0.580

High

1031701

ZMY19
Zinc finger MYND domain-containing protein 19

2

0

High-throughput

0.580

High

1031702

CHFR
E3 ubiquitin-protein ligase CHFR

1

3

Small-scale

0.579

High

452410

PGFRB
Platelet-derived growth factor receptor beta

1

20

Small-scale

0.575

High

127495

RPOM
DNA-directed RNA polymerase, mitochondrial

2

1

High-throughput

0.571

High

166920

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

2

7

High-throughput

0.571

High

320849

HS74L
Heat shock 70 kDa protein 4L

2

20

High-throughput

0.571

High

323731

BAG2
BAG family molecular chaperone regulator 2

2

3

High-throughput

0.571

High

325158

AIFM1
Apoptosis-inducing factor 1, mitochondrial

2

1

High-throughput

0.571

High

388413

HSPB1
Heat shock protein beta-1

2

10

High-throughput

0.571

High

400298

RLA1
Large ribosomal subunit protein P1

2

2

High-throughput

0.571

High

423219

PDIA1
Protein disulfide-isomerase

2

9

High-throughput

0.571

High

475019

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

2

11

High-throughput

0.571

High

475709

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

11

High-throughput

0.571

High

502054

BIP
Endoplasmic reticulum chaperone BiP

2

20

High-throughput

0.571

High

504021

HSP7C
Heat shock cognate 71 kDa protein

2

18

High-throughput

0.571

High

542306

PLAK
Junction plakoglobin

2

18

High-throughput

0.571

High

557545

PP2BB
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

2

12

High-throughput

0.571

High

564069

HSP76
Heat shock 70 kDa protein 6

2

18

High-throughput

0.571

High

590892

BTF3
Transcription factor BTF3

2

3

High-throughput

0.571

High

606305

CADH3
Cadherin-3

2

13

High-throughput

0.571

High

653247

PYR1
Multifunctional protein CAD

2

7

High-throughput

0.571

High

672106

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

2

4

High-throughput

0.571

High

714211

HSP74
Heat shock 70 kDa protein 4

2

20

High-throughput

0.571

High

716670

CTNA1
Catenin alpha-1

2

5

High-throughput

0.571

High

717053

CTNB1
Catenin beta-1

2

10

High-throughput

0.571

High

751611

GRP75
Stress-70 protein, mitochondrial

2

20

High-throughput

0.571

High

805990

RL5
Large ribosomal subunit protein uL18

2

2

High-throughput

0.571

High

814372

AL1A3
Retinaldehyde dehydrogenase 3

2

1

High-throughput

0.571

High

843650

FXR1
RNA-binding protein FXR1

2

7

High-throughput

0.571

High

850029

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

2

16

High-throughput

0.571

High

902411

RL37
Large ribosomal subunit protein eL37

2

1

High-throughput

0.571

High

924294

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

2

7

High-throughput

0.571

High

927805

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

2

4

High-throughput

0.571

High

928730

RL38
Large ribosomal subunit protein eL38

2

1

High-throughput

0.571

High

930832

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

2

8

High-throughput

0.571

High

994076

PP2BA
Protein phosphatase 3 catalytic subunit alpha

2

17

High-throughput

0.571

High

1031661

RBM39
RNA-binding protein 39

2

17

High-throughput

0.571

High

1031662

FAT1
Protocadherin Fat 1

2

7

High-throughput

0.571

High

1031663

CUL7
Cullin-7

2

2

High-throughput

0.571

High

1031664

SART3
Squamous cell carcinoma antigen recognized by T-cells 3

2

9

High-throughput

0.571

High

1031668

SC23B
Protein transport protein Sec23B

2

3

High-throughput

0.571

High

1031669

TRIP6
Thyroid receptor-interacting protein 6

2

20

High-throughput

0.571

High

1031672

SRSF7
Serine/arginine-rich splicing factor 7

2

14

High-throughput

0.571

High

1031680

DHX30
ATP-dependent RNA helicase DHX30

2

6

High-throughput

0.571

High

1031696

HS105
Heat shock protein 105 kDa

2

20

High-throughput

0.571

High

1031699

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

2

8

High-throughput

0.571

High

1031709

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

2

15

High-throughput

0.571

High

1031711

GTPB4
GTP-binding protein 4

2

5

High-throughput

0.571

High

1031722

AKP8L
A-kinase anchor protein 8-like

2

1

High-throughput

0.571

High

1031723

G3BP2
Ras GTPase-activating protein-binding protein 2

2

10

High-throughput

0.571

High

1031728

EXOS1
Exosome complex component CSL4

2

1

High-throughput

0.571

High

1031730

IF2B2
Insulin-like growth factor 2 mRNA-binding protein 2

2

20

High-throughput

0.571

High

1031690

IKBD
NF-kappa-B inhibitor delta

2

17

High-throughput

0.553

High

1031693

TEKT4
Tektin-4

2

1

High-throughput

0.553

High

274415

CRTAP
Cartilage-associated protein

2

0

High-throughput

0.547

High

1031675

CDC73
Parafibromin

2

0

High-throughput

0.547

High

1031687

PAF1
RNA polymerase II-associated factor 1 homolog

2

0

High-throughput

0.547

High

1031717

EXOS3
Exosome complex component RRP40

2

0

High-throughput

0.547

High

1031700

TRI63
E3 ubiquitin-protein ligase TRIM63

1

20

High-throughput

0.541

High

1031710

TRI55
Tripartite motif-containing protein 55

1

20

High-throughput

0.541

High

1031697

CNOT9
CCR4-NOT transcription complex subunit 9

1

0

Small-scale

0.537

High

927005

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.536

High

1031683

AHNK2
Protein AHNAK2

1

10

High-throughput

0.536

High

1031705

RILP
Rab-interacting lysosomal protein

1

1

High-throughput

0.536

High

489027

H14
Histone H1.4

2

5

High-throughput

0.521

High

508502

TOP1
DNA topoisomerase 1

2

1

High-throughput

0.521

High

559396

H13
Histone H1.3

2

5

High-throughput

0.521

High

559686

H12
Histone H1.2

2

5

High-throughput

0.521

High

802085

NOP2
Probable 28S rRNA

2

1

High-throughput

0.521

High

1031684

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

2

7

High-throughput

0.521

High

1031707

EBP2
Probable rRNA-processing protein EBP2

2

1

High-throughput

0.521

High

1031712

DDX24
ATP-dependent RNA helicase DDX24

2

11

High-throughput

0.521

High

1031714

GRPE1
GrpE protein homolog 1, mitochondrial

2

1

High-throughput

0.521

High

1031719

RBM28
RNA-binding protein 28

2

9

High-throughput

0.521

High

1031724

L10K
Leydig cell tumor 10 kDa protein homolog

2

1

High-throughput

0.521

High

345418

FOS
Protein c-Fos

1

2

High-throughput

0.515

High

358754

CRYAA
Alpha-crystallin A chain

1

10

High-throughput

0.515

High

535384

GFAP
Glial fibrillary acidic protein

1

20

High-throughput

0.515

High

1031665

SETB1
Histone-lysine N-methyltransferase SETDB1

1

6

High-throughput

0.515

High

1031691

LMO3
LIM domain only protein 3

1

20

High-throughput

0.515

High

1031694

JPH3
Junctophilin-3

1

4

High-throughput

0.515

High

1031666

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

0

High-throughput

0.513

High

1031688

CCYL1
Cyclin-Y-like protein 1

1

0

High-throughput

0.513

High

1031716

NRN1
Neuritin

1

0

High-throughput

0.513

High

1031703

MEG10
Multiple epidermal growth factor-like domains protein 10

1

13

Small-scale

0.508

High

394658

A4
Amyloid-beta precursor protein

1

11

High-throughput

0.501

High

974799

CAV1
Caveolin-1

1

8

Small-scale

0.501

High

1031682

ZDH17
Palmitoyltransferase ZDHHC17

1

13

High-throughput

0.494

High

839371

GATM
Glycine amidinotransferase, mitochondrial

1

0

High-throughput

0.493

High

661250

S10A2
Protein S100-A2

1

5

High-throughput

0.489

High

795746

MAGA3
Melanoma-associated antigen 3

1

5

High-throughput

0.489

High

162703

XPO1
Exportin-1

1

5

High-throughput

0.479

High

352093

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

2

High-throughput

0.479

High

602907

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

10

Small-scale

0.479

High

622736

IL4RA
Interleukin-4 receptor subunit alpha

1

20

Small-scale

0.479

High

682263

IL2RG
Cytokine receptor common subunit gamma

1

20

Small-scale

0.479

High

808114

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

15

Small-scale

0.479

High

1031677

RICTR
Rapamycin-insensitive companion of mTOR

1

2

High-throughput

0.479

High

1031698

HDAC2
Histone deacetylase 2

1

11

High-throughput

0.479

High

1031681

Q86V38
Atrophin 1

1

9

High-throughput

0.470

High

822597

HSP77
Putative heat shock 70 kDa protein 7

1

20

High-throughput

0.445

High

1031686

MIA40
Mitochondrial intermembrane space import and assembly protein 40

2

0

High-throughput

0.298

High

1031692

TFB1M
Dimethyladenosine transferase 1, mitochondrial

2

0

High-throughput

0.298

High

1031695

H1X
Histone H1.10

2

0

High-throughput

0.298

High

1031727

RCL1
RNA 3'-terminal phosphate cyclase-like protein

2

0

High-throughput

0.298

High

1031689

NOA1
Nitric oxide-associated protein 1

1

0

High-throughput

0.265

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024