HitPredict

Interactor 1: EWS (Q01844)
RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein)
Gene: EWSR1

Interactor 2: RBP56 (Q92804)
TATA-binding protein-associated factor 2N (68 kDa TATA-binding protein-associated factor) (TAF(II)68) (TAFII68) (RNA-binding protein 56)
Gene: TAF15

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	29884807, 23975937
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003712 - transcription coregulator activity GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm and 1 others more... GO:0046872 - metal ion binding
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 656 Hs			1 592
+	Hs
		1271146 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		RBP56_HUMAN (1-394): 3.45e-37: 148: 100.00
+	Hs
		726966 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		FUS_HUMAN (8-381): 2.72e-32: 132: 39.28
+	Hs
		212166 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		HTSF1_HUMAN (113-325): 5.58e-31: 130: 18.06
+	Hs
		967116 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		EWS_HUMAN (4-383): 3.73e-35: 142: 32.96
+	Hs
		726756 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		FUS_HUMAN (8-381): 2.72e-32: 132: 39.28
+	Hs
		212130 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		HTSF1_HUMAN (113-325): 5.58e-31: 130: 18.06
+	Hs
		318605 EYA4_HUMAN (3-271): 6.07e-39: 154: 18.02		EWS_HUMAN (4-383): 3.73e-35: 142: 32.96
+	Hs
		726619 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		FUS_HUMAN (8-381): 2.72e-32: 132: 39.28
+	Hs
		409731 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		CO5A2_HUMAN (316-592): 1.49e-10: 66.4: 20.42
+	Mm
		93247 E9PWQ3_MOUSE (3-214): 1.03e-25: 115: 9.72		E9PWQ3_MOUSE (3-229): 9.87e-26: 115: 10.73
+	Rn
		358576 CO1A1_RAT (2-511): 1.09e-19: 96.4: 14.92		CO1A2_RAT (4-432): 5.82e-22: 102: 10.18
+	Hs
		358440 CO2A1_HUMAN (3-462): 5.09e-19: 94.1: 8.59		CO1A1_HUMAN (15-538): 4.5e-17: 87.6: 13.12
+	Hs
		358439 CO1A1_HUMAN (2-506): 1.09e-18: 92.9: 14.74		CO1A1_HUMAN (15-538): 4.5e-17: 87.6: 13.12
+	Dm
		435987 CO4A1_DROME (378-655): 1.52e-22: 105: 15.68		Q9VMV5_DROME (3-326): 3.91e-13: 74.9: 8.72
+	Hs
		358581 CO2A1_HUMAN (3-462): 5.09e-19: 94.1: 8.59		CO2A1_HUMAN (294-590): 1.58e-09: 63.3: 16.08