Protein: ZDH18
Palmitoyltransferase ZDHHC18 (EC 2.3.1.225) (DHHC domain-containing cysteine-rich protein 18) (DHHC-18) (Zinc finger DHHC domain-containing protein 18)

Gene: ZDH18, ZDHHC18
Organism: Homo sapiens
Interactions: 72
UniProt ID: Q9NUE0

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0005783 - endoplasmic reticulum
GO:0005794 - Golgi apparatus
GO:0005829 - cytosol
GO:0006612 - protein targeting to membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

212495

SPIT2
Kunitz-type protease inhibitor 2

3

1

High-throughput

0.667

High

1359362

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

2

6

High-throughput

0.628

High

1436646

IPPK
Inositol-pentakisphosphate 2-kinase

2

2

High-throughput

0.628

High

1315330

ZDH23
Palmitoyltransferase ZDHHC23

1

5

Small-scale

0.618

High

1029442

IL9R
Interleukin-9 receptor

3

3

High-throughput

0.609

High

1366263

LPAR1
Lysophosphatidic acid receptor 1

3

8

High-throughput

0.609

High

337142

NPT2B
Sodium-dependent phosphate transport protein 2B

3

1

High-throughput

0.604

High

1340748

TPC2
Two pore channel protein 2

2

0

High-throughput

0.602

High

1279128

GOGA7
Golgin subfamily A member 7

1

6

Small-scale

0.575

High

62167

KLRG2
Killer cell lectin-like receptor subfamily G member 2

2

2

High-throughput

0.574

High

878102

AGRE5
Adhesion G protein-coupled receptor E5

2

4

High-throughput

0.574

High

1128959

I13R2
Interleukin-13 receptor subunit alpha-2

2

6

High-throughput

0.574

High

1153344

AAAT
Neutral amino acid transporter B(0)

2

3

High-throughput

0.574

High

1250233

DLK2
Protein delta homolog 2

2

4

High-throughput

0.574

High

1355938

GDPD5
Glycerophosphodiester phosphodiesterase domain-containing protein 5

2

2

High-throughput

0.574

High

1449774

PCDC2
Protocadherin alpha-C2

2

3

High-throughput

0.574

High

456021

ASGR2
Asialoglycoprotein receptor 2

2

1

High-throughput

0.558

High

906936

GPM6A
Neuronal membrane glycoprotein M6-a

2

1

High-throughput

0.558

High

1393216

TM169
Transmembrane protein 169

2

2

High-throughput

0.549

High

132668

UPK1A
Uroplakin-1a

1

10

High-throughput

0.536

High

349590

TSN15
Tetraspanin-15

1

9

High-throughput

0.536

High

922843

ITA8
Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain]

1

1

High-throughput

0.536

High

1203811

TTMP
TPA-induced transmembrane protein

1

1

High-throughput

0.536

High

596537

CTLA4
Cytotoxic T-lymphocyte protein 4

1

0

High-throughput

0.513

High

164966

TR10C
Tumor necrosis factor receptor superfamily member 10C

1

3

High-throughput

0.489

High

848574

MAGA8
Melanoma-associated antigen 8

1

1

High-throughput

0.489

High

1254086

LRC55
Leucine-rich repeat-containing protein 55

1

2

High-throughput

0.489

High

1333614

SIDT2
SID1 transmembrane family member 2

1

2

High-throughput

0.489

High

1399064

TMM74
Transmembrane protein 74

1

1

High-throughput

0.489

High

1432431

TTYH1
Protein tweety homolog 1

1

1

High-throughput

0.489

High

1449771

TM63C
Osmosensitive cation channel TMEM63C

1

1

High-throughput

0.489

High

1449773

PCDGL
Protocadherin gamma-C4

1

3

High-throughput

0.489

High

132800

PK3CD
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

1

5

Small-scale

0.479

High

255491

SNX2
Sorting nexin-2

1

2

Small-scale

0.479

High

374230

RASN
GTPase NRas

1

20

High-throughput

0.479

High

374966

RASH
GTPase HRas

1

20

High-throughput

0.479

High

375999

RASK
GTPase KRas

1

20

High-throughput

0.479

High

414709

P53
Cellular tumor antigen p53

1

1

Small-scale

0.479

High

625847

RXRA
Retinoic acid receptor RXR-alpha

1

1

Small-scale

0.479

High

728445

AKT1
RAC-alpha serine/threonine-protein kinase

1

1

Small-scale

0.479

High

765924

BMI1
Polycomb complex protein BMI-1

1

4

Small-scale

0.479

High

772524

IRS1
Insulin receptor substrate 1

1

2

Small-scale

0.479

High

839095

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

5

Small-scale

0.479

High

839384

MTOR
Serine/threonine-protein kinase mTOR

1

4

Small-scale

0.479

High

983068

RS25
Small ribosomal subunit protein eS25

1

1

Small-scale

0.479

High

1055865

RING1
E3 ubiquitin-protein ligase RING1

1

4

Small-scale

0.479

High

1109516

ATR
Serine/threonine-protein kinase ATR

1

3

High-throughput

0.479

High

1111983

SNX1
Sorting nexin-1

1

2

Small-scale

0.479

High

1314841

ERF3B
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B

1

1

Small-scale

0.479

High

1370133

RENT1
Regulator of nonsense transcripts 1

1

1

Small-scale

0.479

High

1400928

VPS35
Vacuolar protein sorting-associated protein 35

1

1

Small-scale

0.479

High

1449772

SNX6
Sorting nexin-6

1

2

Small-scale

0.479

High

281789

VP26A
Vacuolar protein sorting-associated protein 26A

1

0

Small-scale

0.458

High

377745

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

Small-scale

0.458

High

476845

RSSA
Small ribosomal subunit protein uS2

1

0

Small-scale

0.458

High

898259

R144A
E3 ubiquitin-protein ligase RNF144A

1

0

Small-scale

0.458

High

973602

RS11
Small ribosomal subunit protein uS17

1

0

Small-scale

0.458

High

976782

ERF1
Eukaryotic peptide chain release factor subunit 1

1

0

Small-scale

0.458

High

1153793

NCOA1
Nuclear receptor coactivator 1

1

0

Small-scale

0.458

High

261448

TBL1X
F-box-like/WD repeat-containing protein TBL1X

1

3

Small-scale

0.437

High

439860

INSR
Insulin receptor

1

7

Small-scale

0.437

High

1060639

PPARA
Peroxisome proliferator-activated receptor alpha

1

2

Small-scale

0.437

High

1404790

RING2
E3 ubiquitin-protein ligase RING2

1

4

Small-scale

0.437

High

1412825

PCGF1
Polycomb group RING finger protein 1

1

4

Small-scale

0.437

High

845218

SATT
Neutral amino acid transporter A

1

3

High-throughput

0.407

High

1353728

MOT10
Monocarboxylate transporter 10

1

5

High-throughput

0.407

High

71255

HIDE1
Protein HIDE1

1

0

High-throughput

0.279

Low

1200377

KCP3
Keratinocyte-associated protein 3

1

0

High-throughput

0.279

Low

1249513

VSTM1
V-set and transmembrane domain-containing protein 1

1

0

High-throughput

0.279

Low

420288

IGF1
Insulin-like growth factor 1

1

0

Small-scale

0.249

Low

1403029

SIN3A
Paired amphipathic helix protein Sin3a

1

0

Small-scale

0.249

Low

1449775

NCOR2
Nuclear receptor corepressor 2

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025