HitPredict

Interactor 1: KMT2A (Q03164)
Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
Gene: KMT2A

Interactor 2: PDIA6 (Q15084)
Protein disulfide-isomerase A6 (EC 5.3.4.1) (Endoplasmic reticulum protein 5) (ER protein 5) (ERp5) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7)
Gene: PDIA6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34349018
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 3969 Hs			1 440
+	Hs
		671790 KMT2A_HUMAN (1-3969): 0: 3187: 100.00		PDIA3_HUMAN (13-386): 9.31e-10: 62.6: 11.02
+	Hs
		1067714 EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54		PDIA6_HUMAN (1-440): 1.21e-134: 396: 100.00
+	Hs
		1080123 EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54		TXND5_HUMAN (177-431): 3.21e-41: 153: 20.37
+	Hs
		531841 EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54		PDIA4_HUMAN (67-271): 1.28e-17: 87.3: 22.28
+	Hs
		423240 EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54		PDIA1_HUMAN (62-387): 6.18e-10: 63: 11.59
+	Hs
		671823 EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54		PDIA3_HUMAN (13-386): 9.31e-10: 62.6: 11.02