HitPredict

Interactor 1: E9PXB7 (E9PXB7)
E3 ubiquitin-protein ligase (EC 2.3.2.26)
Gene: Nedd4l

Interactor 2: SCNNB (Q9WU38)
Epithelial sodium channel subunit beta (Amiloride-sensitive sodium channel subunit beta) (Beta-NaCH) (Epithelial Na(+) channel subunit beta) (Beta-ENaC) (Nonvoltage-gated sodium channel 1 subunit beta) (SCNEB)
Gene: Scnn1b

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.50	0.594

Property	Details
Experiments	12424229, 17544362, 15123669
Identification Methods	far western blotting, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 835 Mm			1 638
+	Mm
		1298424 NED4L_MOUSE (1-835): 0: 951: 97.54		SCNNB_MOUSE (1-638): 0: 717: 100.00
+	Hs
		902326 NED4L_HUMAN (1-835): 0: 944: 95.79		SCNNB_HUMAN (1-638): 0: 706: 83.91
+	Hs
		861521 NEDD4_HUMAN (1-835): 0: 846: 60.41		SCNNB_HUMAN (1-638): 0: 706: 83.91
+	Mm
		97739 E9PXB7_MOUSE (1-835): 0: 959: 100.00		SCNNA_MOUSE (21-637): 0: 580: 32.60
+	Mm
		97756 E9PXB7_MOUSE (1-835): 0: 959: 100.00		SCNNG_MOUSE (16-623): 0: 579: 35.71
+	Hs
		788541 NED4L_HUMAN (1-835): 0: 944: 95.79		SCNNA_HUMAN (21-625): 0: 585: 32.25
+	Hs
		902341 NED4L_HUMAN (1-835): 0: 944: 95.79		SCNNG_HUMAN (19-624): 0: 581: 35.43
+	Hs
		788518 NEDD4_HUMAN (1-835): 0: 846: 60.41		SCNNA_HUMAN (21-625): 0: 585: 32.25
+	Hs
		861522 NEDD4_HUMAN (1-835): 0: 846: 60.41		SCNNG_HUMAN (19-624): 0: 581: 35.43
+	Hs
		788534 HUWE1_HUMAN (286-833): 3.41e-170: 549: 34.17		SCNNA_HUMAN (21-625): 0: 585: 32.25
+	Hs
		131833 WWP2_HUMAN (24-172): 1.67e-20: 99.1: 20.00		SCNNB_HUMAN (1-638): 0: 706: 83.91
+	Hs
		902323 HECW1_HUMAN (153-500): 2.69e-18: 92.6: 16.54		SCNNB_HUMAN (1-638): 0: 706: 83.91
+	Hs
		902325 ITCH_HUMAN (10-115): 4.24e-18: 91.4: 21.19		SCNNB_HUMAN (1-638): 0: 706: 83.91
+	Hs
		788545 WWP1_HUMAN (6-182): 1e-28: 125: 22.28		SCNNA_HUMAN (21-625): 0: 585: 32.25
+	Hs
		131774 WWP2_HUMAN (24-172): 1.67e-20: 99.1: 20.00		SCNNA_HUMAN (21-625): 0: 585: 32.25
+	Rn
		788567 Q4V8H7_RAT (29-142): 2.02e-19: 95.6: 21.01		SCNNG_RAT (16-623): 0: 586: 36.00
+	Hs
		131834 WWP2_HUMAN (24-172): 1.67e-20: 99.1: 20.00		SCNNG_HUMAN (19-624): 0: 581: 35.43
+	Hs
		788533 HECW1_HUMAN (153-500): 2.69e-18: 92.6: 16.54		SCNNA_HUMAN (21-625): 0: 585: 32.25
+	Hs
		788540 ITCH_HUMAN (10-115): 4.24e-18: 91.4: 21.19		SCNNA_HUMAN (21-625): 0: 585: 32.25
+	Mm
		861878 NEDD4_MOUSE (10-135): 1.9e-17: 89.5: 16.67		SCNNA_MOUSE (21-637): 0: 580: 32.60