HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: RIN3 (Q8TB24)
Ras and Rab interactor 3 (Ras interaction/interference protein 3)
Gene: RIN3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	32552912, 17474147
Identification Methods	affinity chromatography technology, peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 985
+	Hs
		72726 B0LPF3_HUMAN (1-217): 1.28e-70: 216: 100.00		RIN3_HUMAN (1-985): 0: 555: 100.00
+	Hs
		440150 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		RIN3_HUMAN (1-985): 0: 555: 100.00
+	Hs
		69579 A8K3B6_HUMAN (2-139): 3.9e-24: 100: 36.24		RIN3_HUMAN (1-985): 0: 555: 100.00
+	Hs
		834211 CSK_HUMAN (2-139): 3.94e-24: 100: 36.24		RIN3_HUMAN (1-985): 0: 555: 100.00
+	Hs
		594053 NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14		RIN3_HUMAN (1-985): 0: 555: 100.00
+	Hs
		73623 B2R6S4_HUMAN (5-145): 8.94e-23: 96.3: 33.14		RIN3_HUMAN (1-985): 0: 555: 100.00
+	Hs
		594023 NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14		Q6NSK7_HUMAN (1-985): 5.42e-173: 529: 89.14
+	Hs
		176259 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		SYNJ2_HUMAN (181-535): 2.14e-27: 122: 16.89
+	Hs
		590268 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		MUC1_HUMAN (124-732): 1.45e-20: 100: 11.75
+	Hs
		440243 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		MACF1_HUMAN (595-857): 3.27e-44: 177: 15.83
+	Hs
		215914 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		SYNJ1_HUMAN (23-494): 7.12e-10: 65.6: 7.69
+	Hs
		439935 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		MUC1_HUMAN (124-732): 1.45e-20: 100: 11.75
+	Hs
		176246 NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14		SYNJ2_HUMAN (181-535): 2.14e-27: 122: 16.89
+	Hs
		176239 ABL1_HUMAN (4-139): 4.41e-22: 95.5: 35.46		SYNJ2_HUMAN (181-535): 2.14e-27: 122: 16.89
+	Hs
		594151 NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14		MTCL1_HUMAN (229-786): 2.04e-26: 119: 13.99
+	Hs
		362149 ABL1_HUMAN (4-139): 4.41e-22: 95.5: 35.46		MUC1_HUMAN (124-732): 1.45e-20: 100: 11.75
+	Mm
		362453 ABL1_MOUSE (4-139): 4.08e-22: 95.9: 35.46		RIN1_MOUSE (19-305): 1.14e-20: 99: 25.50
+	Hs
		362285 ABL1_HUMAN (4-139): 4.41e-22: 95.5: 35.46		RIN1_HUMAN (6-327): 1.37e-20: 99: 26.44
+	Hs
		215893 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		SYNJ1_HUMAN (23-494): 7.12e-10: 65.6: 7.69
+	Hs
		215903 NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14		SYNJ1_HUMAN (23-494): 7.12e-10: 65.6: 7.69