Protein: MTCL1
Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2)

Gene: MTCL1
Organism: Homo sapiens
Interactions: 82
UniProt ID: Q9Y4B5

Gene Ontology (top 5):
GO:0000776 - kinetochore
GO:0000922 - spindle pole
GO:0001578 - microtubule bundle formation
GO:0003723 - RNA binding
GO:0005615 - extracellular space

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1270564

MARK2
Serine/threonine-protein kinase MARK2

5

16

Small-scale

0.720

High

1023922

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

4

4

High-throughput

0.699

High

991786

DYL1
Dynein light chain 1, cytoplasmic

4

4

High-throughput

0.691

High

1428228

NDEL1
Nuclear distribution protein nudE-like 1

3

17

High-throughput

0.662

High

866882

CAZA2
F-actin-capping protein subunit alpha-2

5

7

High-throughput

0.654

High

718066

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

3

2

High-throughput

0.650

High

867551

CAPZB
F-actin-capping protein subunit beta

3

4

High-throughput

0.650

High

1331023

ANR44
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B

4

6

High-throughput

0.630

High

1490917

2ABG
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform

4

4

High-throughput

0.630

High

692171

MARK3
MAP/microtubule affinity-regulating kinase 3

2

10

High-throughput

0.628

High

1390764

DYL2
Dynein light chain 2, cytoplasmic

2

4

High-throughput

0.601

High

69849

ZN785
Zinc finger protein 785

2

4

High-throughput

0.574

High

171947

ZN263
Zinc finger protein 263

2

2

High-throughput

0.574

High

1460849

ZN223
Zinc finger protein 223

2

1

High-throughput

0.574

High

848843

MAGAA
Melanoma-associated antigen 10

2

11

High-throughput

0.549

High

1412060

WDR83
WD repeat domain-containing protein 83

2

10

High-throughput

0.549

High

915229

CAZA1
F-actin-capping protein subunit alpha-1

1

7

High-throughput

0.536

High

926251

ICLN
Methylosome subunit pICln

1

1

High-throughput

0.536

High

1143919

2A5A
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

1

4

High-throughput

0.536

High

1340693

NEDD1
Protein NEDD1

1

6

High-throughput

0.536

High

1383903

EFMT3
EEF1A lysine methyltransferase 3

1

10

High-throughput

0.536

High

1396685

MARK4
MAP/microtubule affinity-regulating kinase 4

1

16

High-throughput

0.536

High

1404540

CDC5L
Cell division cycle 5-like protein

1

3

High-throughput

0.536

High

1433813

SENP3
Sentrin-specific protease 3

1

1

High-throughput

0.536

High

1435491

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.536

High

1447877

DDX21
Nucleolar RNA helicase 2

1

3

High-throughput

0.536

High

1491121

SBDS
Ribosome maturation protein SBDS

1

7

High-throughput

0.536

High

1491308

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

1

1

High-throughput

0.536

High

1434423

RNF41
E3 ubiquitin-protein ligase NRDP1

2

12

Small-scale

0.533

High

1462318

SNX6
Sorting nexin-6

1

0

High-throughput

0.513

High

996902

TBA1B
Tubulin alpha-1B chain

1

3

Small-scale

0.501

High

1006821

SRPK2
SRSF protein kinase 2

1

17

High-throughput

0.501

High

1108769

TBB3
Tubulin beta-3 chain

1

2

Small-scale

0.501

High

1491379

MTCL1
Microtubule cross-linking factor 1

1

18

Small-scale

0.501

High

443108

PTMA
Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]

1

3

High-throughput

0.489

High

517842

GLI4
Zinc finger protein GLI4

1

2

High-throughput

0.489

High

600472

ZNF26
Zinc finger protein 26

1

1

High-throughput

0.489

High

1461437

PNMA2
Paraneoplastic antigen Ma2

1

6

High-throughput

0.489

High

164142

NDC80
Kinetochore protein NDC80 homolog

1

15

High-throughput

0.479

High

223449

PRC1
Protein regulator of cytokinesis 1

1

8

High-throughput

0.479

High

404567

GCR
Glucocorticoid receptor

1

18

High-throughput

0.479

High

437400

K2C8
Keratin, type II cytoskeletal 8

1

9

High-throughput

0.479

High

472372

CFAH
Complement factor H

1

3

Small-scale

0.479

High

535704

BIP
Endoplasmic reticulum chaperone BiP

1

7

High-throughput

0.479

High

730390

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.479

High

891372

GSK3A
Glycogen synthase kinase-3 alpha

1

20

High-throughput

0.479

High

891911

GSK3B
Glycogen synthase kinase-3 beta

1

20

High-throughput

0.479

High

920394

PLK1
Serine/threonine-protein kinase PLK1

1

1

High-throughput

0.479

High

967062

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

1036020

KIF23
Kinesin-like protein KIF23

1

12

High-throughput

0.479

High

1045946

TF65
Transcription factor p65

1

5

High-throughput

0.479

High

1049942

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

1108312

SQSTM
Sequestosome-1

1

7

High-throughput

0.479

High

1114737

CUL3
Cullin-3

1

11

High-throughput

0.479

High

1138809

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

4

High-throughput

0.479

High

1141098

KIF14
Kinesin-like protein KIF14

1

10

High-throughput

0.479

High

1197140

AMOT
Angiomotin

1

18

High-throughput

0.479

High

1220907

RN123
E3 ubiquitin-protein ligase RNF123

1

9

High-throughput

0.479

High

1380287

FBXW7
F-box/WD repeat-containing protein 7

1

10

High-throughput

0.479

High

1446851

TRI36
E3 ubiquitin-protein ligase TRIM36

1

17

High-throughput

0.479

High

1460328

XPO7
Exportin-7

1

2

High-throughput

0.479

High

1461939

FZR1
Fizzy-related protein homolog

1

11

High-throughput

0.479

High

1461989

MYO6
Unconventional myosin-VI

1

18

High-throughput

0.479

High

1490794

ZBTB1
Zinc finger and BTB domain-containing protein 1

1

3

Small-scale

0.479

High

1432614

CK068
UPF0696 protein C11orf68

1

0

High-throughput

0.460

High

982595

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

1429894

TOLIP
Toll-interacting protein

1

0

High-throughput

0.458

High

889531

CLK1
Dual specificity protein kinase CLK1

1

19

High-throughput

0.457

High

594151

NCK1
SH2/SH3 adapter protein NCK1

1

14

High-throughput

0.445

High

1203306

ODFP2
Outer dense fiber protein 2

1

16

High-throughput

0.445

High

1243441

CNKR3
Connector enhancer of kinase suppressor of ras 3

1

2

High-throughput

0.445

High

1315541

KATL2
Katanin p60 ATPase-containing subunit A-like 2

1

7

High-throughput

0.445

High

1384315

SH3K1
SH3 domain-containing kinase-binding protein 1

1

12

High-throughput

0.445

High

106907

APRIO
Alternative prion protein

1

5

High-throughput

0.437

High

907863

CLCN7
H(+)/Cl(-) exchange transporter 7

1

1

High-throughput

0.437

High

1227770

A16L1
Autophagy-related protein 16-1

1

12

High-throughput

0.437

High

1324368

STK40
Serine/threonine-protein kinase 40

1

20

Small-scale

0.437

High

1447037

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

6

High-throughput

0.437

High

1278598

P4HA3
Prolyl 4-hydroxylase subunit alpha-3

3

0

High-throughput

0.345

High

1337757

ZN555
Zinc finger protein 555

2

0

High-throughput

0.328

High

1152900

NSDHL
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025