HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: ABI3 (Q9P2A4)
ABI gene family member 3 (New molecule including SH3) (Nesh)
Gene: ABI3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.573

Property	Details
Experiments	25416956
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0030036 - actin cytoskeleton organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 366
+	Hs
		987636 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		SRC8_HUMAN (40-363): 4.99e-43: 158: 16.12
+	Hs
		571667 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		HCLS1_HUMAN (20-363): 4.03e-37: 141: 13.98
+	Hs
		988022 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		ASAP1_HUMAN (223-362): 2.84e-24: 106: 23.03
+	Hs
		987766 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		ABI1_HUMAN (124-363): 6.4e-21: 95.9: 24.49
+	Mm
		362451 ABL1_MOUSE (4-139): 4.08e-22: 95.9: 35.46		ABI1_MOUSE (1-314): 3.09e-64: 213: 34.35
+	Dm
		1061449 GRAP_DROME (1-215): 1.24e-56: 180: 62.33		Q9VDF4_DROME (89-363): 8.19e-31: 124: 16.33
+	Hs
		987513 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		GRB2_HUMAN (312-363): 4.05e-14: 72.7: 28.30
+	Rn
		74730 B2RZ33_RAT (5-145): 9.03e-23: 96.3: 33.14		SRC8_RAT (40-363): 8.53e-44: 160: 13.89
+	Mm
		440275 LCK_MOUSE (3-202): 5.91e-38: 139: 28.44		HCLS1_MOUSE (86-363): 1.63e-28: 117: 13.67
+	Hs
		362366 ABL1_HUMAN (4-139): 4.41e-22: 95.5: 35.46		PACN1_HUMAN (11-363): 1.32e-37: 142: 12.67
+	Hs
		440142 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		ABI1_HUMAN (124-363): 6.4e-21: 95.9: 24.49
+	Hs
		594115 NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14		ABI2_HUMAN (109-363): 1.97e-25: 108: 23.18
+	Hs
		594133 NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14		ASAP1_HUMAN (223-362): 2.84e-24: 106: 23.03
+	Hs
		841021 FRK_HUMAN (4-139): 3.55e-23: 98.2: 38.00		ABI1_HUMAN (124-363): 6.4e-21: 95.9: 24.49
+	Dm
		362479 ABL_DROME (4-135): 1.01e-22: 97.4: 37.68		Q9Y0S9_DROME (260-364): 6.86e-21: 95.5: 38.32
+	Hs
		594045 NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14		ABI1_HUMAN (124-363): 6.4e-21: 95.9: 24.49
+	Hs
		362318 ABL1_HUMAN (4-139): 4.41e-22: 95.5: 35.46		ABI1_HUMAN (124-363): 6.4e-21: 95.9: 24.49
+	Hs
		834167 CSK_HUMAN (2-139): 3.94e-24: 100: 36.24		GRB2_HUMAN (312-363): 4.05e-14: 72.7: 28.30
+	Hs
		593961 NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14		GRB2_HUMAN (312-363): 4.05e-14: 72.7: 28.30
+	Hs
		362234 ABL1_HUMAN (4-139): 4.41e-22: 95.5: 35.46		GRB2_HUMAN (312-363): 4.05e-14: 72.7: 28.30