HitPredict

Interactor 1: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Interactor 2: RON (Q04912)
Macrophage-stimulating protein receptor (MSP receptor) (EC 2.7.10.1) (CDw136) (Protein-tyrosine kinase 8) (p185-Ron) (CD antigen CD136) [Cleaved into: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain]
Gene: MST1R

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	14505491
Identification Methods	affinity chromatography technology, coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	14-3-3~PK_Tyr_Ser-Thr
Common GO terms	GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 1400
+	Hs
		971428 1433E_HUMAN (2-241): 9.95e-144: 403: 68.18		RON_HUMAN (19-1400): 0: 1279: 100.00
+	Hs
		690930 1433T_HUMAN (1-245): 2.61e-140: 395: 79.59		RON_HUMAN (19-1400): 0: 1279: 100.00
+	Mm
		591112 1433Z_MOUSE (1-245): 3.49e-145: 407: 99.59		MET_MOUSE (1-1364): 0: 1079: 33.50
+	Hs
		472036 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		MET_HUMAN (1-1391): 0: 1071: 32.30
+	Hs
		641153 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		FGFR2_HUMAN (784-1397): 2.95e-113: 378: 23.33
+	Hs
		541361 1433B_HUMAN (1-242): 9.05e-140: 393: 87.60		FGFR1_HUMAN (767-1397): 1.17e-113: 379: 22.74
+	Hs
		650063 1433B_HUMAN (1-242): 9.05e-140: 393: 87.60		FGFR3_HUMAN (1015-1400): 1.19e-113: 379: 32.20
+	Hs
		641129 1433B_HUMAN (1-242): 9.05e-140: 393: 87.60		FGFR2_HUMAN (784-1397): 2.95e-113: 378: 23.33
+	Hs
		971456 1433E_HUMAN (2-241): 9.95e-144: 403: 68.18		MERTK_HUMAN (1037-1348): 1.21e-59: 225: 37.65
+	Hs
		690954 1433T_HUMAN (1-245): 2.61e-140: 395: 79.59		MERTK_HUMAN (1037-1348): 1.21e-59: 225: 37.65
+	Hs
		720182 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		UFO_HUMAN (1062-1348): 3.98e-56: 213: 40.47
+	Hs
		465479 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		IGF1R_HUMAN (1072-1343): 3.58e-52: 204: 37.93
+	Hs
		465471 1433E_HUMAN (2-241): 9.95e-144: 403: 68.18		IGF1R_HUMAN (1072-1343): 3.58e-52: 204: 37.93
+	Hs
		720144 1433B_HUMAN (1-242): 9.05e-140: 393: 87.60		UFO_HUMAN (1062-1348): 3.98e-56: 213: 40.47
+	Hs
		971523 1433E_HUMAN (2-241): 9.95e-144: 403: 68.18		FAK2_HUMAN (1075-1384): 4.29e-51: 199: 35.65
+	Hs
		465413 1433T_HUMAN (1-245): 2.61e-140: 395: 79.59		IGF1R_HUMAN (1072-1343): 3.58e-52: 204: 37.93
+	Hs
		465424 1433B_HUMAN (1-242): 9.05e-140: 393: 87.60		IGF1R_HUMAN (1072-1343): 3.58e-52: 204: 37.93
+	Hs
		834168 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		CSK_HUMAN (1086-1344): 9.76e-51: 188: 40.00
+	Hs
		439659 1433B_HUMAN (1-242): 9.05e-140: 393: 87.60		INSR_HUMAN (1073-1338): 8.51e-51: 199: 38.73
+	Hs
		834166 1433E_HUMAN (2-241): 9.95e-144: 403: 68.18		CSK_HUMAN (1086-1344): 9.76e-51: 188: 40.00