HitPredict

Interactor 1: GRAP (Q08012)
Growth factor receptor-bound protein 2 (Downstream of receptor kinase) (Protein enhancer of sevenless 2B)
Gene: drk

Interactor 2: Q7KV89 (Q7KV89)
non-specific serine/threonine protein kinase (EC 2.7.11.1)
Gene: msn

Species: Drosophila melanogaster

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	22028469
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0043408 - regulation of MAPK cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 211 Dm			1 1101
+	Ce
		1095301 Q95PW9_CAEEL (4-147): 4.6e-19: 85.9: 33.14		MIG15_CAEEL (13-1101): 0: 956: 52.00
+	Hs
		924703 GRB2_HUMAN (1-210): 1.39e-64: 200: 62.62		MINK1_HUMAN (11-741): 2.28e-127: 423: 43.91
+	Hs
		924733 GRB2_HUMAN (1-210): 1.39e-64: 200: 62.62		MYO3B_HUMAN (20-422): 1.87e-114: 387: 40.39
+	Hs
		324782 GRB2_HUMAN (1-210): 1.39e-64: 200: 62.62		M4K4_HUMAN (9-681): 9.31e-114: 384: 45.10
+	Hs
		924683 GRB2_HUMAN (1-210): 1.39e-64: 200: 62.62		M4K3_HUMAN (24-385): 2.65e-114: 377: 42.01
+	Hs
		924984 GRB2_HUMAN (1-210): 1.39e-64: 200: 62.62		M4K5_HUMAN (26-525): 4.11e-113: 373: 32.08
+	Hs
		557740 NCK1_HUMAN (5-143): 2.4e-20: 89.4: 32.35		MINK1_HUMAN (11-741): 2.28e-127: 423: 43.91
+	Hs
		557820 NCK1_HUMAN (5-143): 2.4e-20: 89.4: 32.35		TNIK_HUMAN (9-786): 3.02e-127: 423: 39.85
+	Hs
		855832 VAV2_HUMAN (2-208): 7.42e-35: 132: 21.75		STK24_HUMAN (27-391): 6.1e-115: 365: 39.57
+	Hs
		337455 ABL1_HUMAN (4-138): 2.7e-23: 99: 36.43		STK4_HUMAN (14-326): 2.2e-121: 383: 42.54
+	Hs
		433470 YES_HUMAN (160-211): 1.47e-10: 61.9: 25.93		SIK2_HUMAN (19-787): 8.32e-128: 414: 15.04
+	Hs
		324734 NCK1_HUMAN (5-143): 2.4e-20: 89.4: 32.35		M4K4_HUMAN (9-681): 9.31e-114: 384: 45.10
+	Hs
		557731 NCK1_HUMAN (5-143): 2.4e-20: 89.4: 32.35		M4K3_HUMAN (24-385): 2.65e-114: 377: 42.01
+	Hs
		557840 NCK1_HUMAN (5-143): 2.4e-20: 89.4: 32.35		M4K5_HUMAN (26-525): 4.11e-113: 373: 32.08
+	Hs
		802792 CRK_HUMAN (48-209): 9e-20: 87: 29.69		M4K5_HUMAN (26-525): 4.11e-113: 373: 32.08
+	Mm
		956970 NCK1_MOUSE (5-143): 1.82e-20: 89.7: 32.35		M4K4_MOUSE (9-670): 5.75e-108: 367: 46.91
+	Hs
		412163 FYN_HUMAN (160-211): 2.56e-12: 66.9: 27.78		STK4_HUMAN (14-326): 2.2e-121: 383: 42.54
+	Hs
		1217590 ITSN2_HUMAN (72-211): 1.54e-13: 70.8: 19.01		M4K3_HUMAN (24-385): 2.65e-114: 377: 42.01
+	Hs
		412425 FYN_HUMAN (160-211): 2.56e-12: 66.9: 27.78		M4K5_HUMAN (26-525): 4.11e-113: 373: 32.08
+	Mm
		292682 GRAP2_MOUSE (3-58): 2.33e-11: 63.8: 33.93		M4K1_MOUSE (26-313): 5.88e-68: 246: 44.86