HitPredict

Interactor 1: PP2AA (P67775)
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16) (Replication protein C) (RP-C)
Gene: PPP2CA

Interactor 2: IGBP1 (P78318)
Immunoglobulin-binding protein 1 (B-cell signal transduction molecule alpha 4) (Protein alpha-4) (CD79a-binding protein 1) (Protein phosphatase 2/4/6 regulatory subunit) (Renal carcinoma antigen NY-REN-16)
Gene: IGBP1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.98	1.00	0.990

Property	Details
Experiments	24484909, 23892082, 26496610, 23591866, 32296183, 16085932, 33961781, 9647778, 20092282, 21454489, 21988832, 27880917, 28330616, 18782753, 10441131, 35271311, 19156129, 24145130, 22167190, unassigned1304
Identification Methods	affinity chromatography technology, pull down, x-ray crystallography, two hybrid, proximity labelling technology, anti tag coimmunoprecipitation, two hybrid array, tandem affinity purification, validated two hybrid, two hybrid prey pooling approach and 1 others more... anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Metallophos~TAP42
Common GO terms	GO:0005829 - cytosol GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 309 Hs			1 339
+	Hs
		977458 PP2AB_HUMAN (1-309): 0: 528: 97.41		IGBP1_HUMAN (1-339): 3.68e-137: 394: 100.00
+	Mm
		977633 PP2AB_MOUSE (1-309): 0: 528: 97.41		IGBP1_MOUSE (2-339): 5.18e-130: 376: 80.47
+	Mm
		994005 PP2AA_MOUSE (1-309): 0: 528: 99.68		IGBP1_MOUSE (2-339): 5.18e-130: 376: 80.47
+	Hs
		951961 PP4C_HUMAN (4-309): 0: 508: 64.82		IGBP1_HUMAN (1-339): 3.68e-137: 394: 100.00
+	Dm
		661973 PP2A_DROME (1-309): 0: 524: 93.85		Q9VJZ5_DROME (11-338): 6.97e-99: 298: 29.57
+	Ce
		113999 PP2A_CAEEL (3-309): 0: 519: 89.25		PP4RS_CAEEL (12-339): 6.7e-99: 297: 30.03
+	Ce
		1445010 PP4C1_CAEEL (3-309): 0: 504: 62.14		PP4RS_CAEEL (12-339): 6.7e-99: 297: 30.03
+	Dm
		304791 PP4C_DROME (9-309): 1.23e-177: 494: 63.58		Q9VJZ5_DROME (11-338): 6.97e-99: 298: 29.57
+	At
		1058785 PP2A3_ARATH (7-309): 0: 511: 80.86		TAP46_ARATH (12-336): 8.66e-86: 266: 21.41
+	At
		1058776 PP2A2_ARATH (9-309): 0: 509: 80.07		TAP46_ARATH (12-336): 8.66e-86: 266: 21.41
+	At
		147070 PP2A5_ARATH (7-309): 0: 508: 80.20		TAP46_ARATH (12-336): 8.66e-86: 266: 21.41
+	At
		874361 PP2A4_ARATH (7-309): 0: 508: 80.86		TAP46_ARATH (12-336): 8.66e-86: 266: 21.41
+	At
		1058780 PP2A1_ARATH (9-309): 0: 505: 80.40		TAP46_ARATH (12-336): 8.66e-86: 266: 21.41
+	Sc
		660880 PP2A2_YEAST (9-309): 0: 528: 76.41		TAP42_YEAST (26-339): 3.9e-75: 237: 23.82
+	At
		873846 PPX1_ARATH (7-309): 5.85e-179: 497: 64.59		TAP46_ARATH (12-336): 8.66e-86: 266: 21.41
+	Sc
		660816 PP2A1_YEAST (10-309): 0: 516: 76.00		TAP42_YEAST (26-339): 3.9e-75: 237: 23.82
+	Sp
		661368 PP2A2_SCHPO (5-309): 0: 504: 79.02		YCJ5_SCHPO (27-339): 1.74e-66: 213: 24.57
+	Sp
		661357 PP2A1_SCHPO (7-309): 1.49e-179: 499: 79.54		YCJ5_SCHPO (27-339): 1.74e-66: 213: 24.57
+	At
		1319915 FYPP3_ARATH (9-309): 1.68e-135: 387: 57.62		TAP46_ARATH (12-336): 8.66e-86: 266: 21.41
+	Sc
		633509 PP11_YEAST (11-309): 1.48e-137: 393: 57.71		TAP42_YEAST (26-339): 3.9e-75: 237: 23.82