Protein: PP2A2
Serine/threonine-protein phosphatase PP2A-2 catalytic subunit (EC 3.1.3.16)

Gene: PP2A2, PPH22
Organism: Saccharomyces cerevisiae S288C
Interactions: 90
UniProt ID: P23595

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0000159 - protein phosphatase type 2A complex
GO:0000278 - mitotic cell cycle
GO:0000779 - condensed chromosome, centromeric region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

660880

TAP42
Type 2A phosphatase-associated protein 42

8

19

Small-scale

0.971

High

660839

2AAA
Protein phosphatase PP2A regulatory subunit A

8

20

Small-scale

0.969

High

660887

TIP41
Type 2A phosphatase activator TIP41

5

5

Small-scale

0.922

High

660853

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

3

20

High-throughput

0.867

High

660769

PP2A1
Serine/threonine-protein phosphatase PP2A-1 catalytic subunit

2

14

High-throughput

0.789

High

660890

PTPA2
Serine/threonine-protein phosphatase 2A activator 2

2

12

Small-scale

0.768

High

660876

2ABA
Protein phosphatase PP2A regulatory subunit B

14

20

Small-scale

0.761

High

660847

CDC27
Anaphase-promoting complex subunit CDC27

1

5

Small-scale

0.647

High

660869

ZDS1
Protein ZDS1

4

5

Small-scale

0.633

High

660871

RTS3
Protein phosphatase type 2A regulatory subunit RTS3

2

2

High-throughput

0.628

High

358970

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

2

1

High-throughput

0.621

High

660873

FAR11
Factor arrest protein 11

1

5

Small-scale

0.621

High

660843

SWE1
Mitosis inhibitor protein kinase SWE1

2

20

Small-scale

0.619

High

660878

RUVB1
RuvB-like protein 1

2

10

High-throughput

0.611

High

660891

RUVB2
RuvB-like protein 2

2

10

High-throughput

0.611

High

660858

SSB2
Ribosome-associated molecular chaperone SSB2

2

17

High-throughput

0.601

High

626596

HSP60
Heat shock protein 60, mitochondrial

2

12

High-throughput

0.584

High

660834

MAS5
Mitochondrial protein import protein MAS5

2

5

High-throughput

0.584

High

660882

SGO1
Shugoshin

2

1

Small-scale

0.584

High

660848

ANM1
Protein arginine N-methyltransferase 1

1

2

Small-scale

0.578

High

660874

ZDS2
Protein ZDS2

2

3

High-throughput

0.567

High

660832

SCJ1
DnaJ-related protein SCJ1

2

5

High-throughput

0.565

High

419608

H2A2
Histone H2A.2

1

5

High-throughput

0.536

High

470103

SPS1
Sporulation-specific protein 1

1

20

High-throughput

0.536

High

644870

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

5

High-throughput

0.536

High

656367

KC11
Casein kinase I homolog 1

1

14

High-throughput

0.536

High

660841

HSP7F
Heat shock protein homolog SSE1

1

20

High-throughput

0.536

High

636538

PSA7
Probable proteasome subunit alpha type-7

1

1

High-throughput

0.515

High

636624

PSA1
Proteasome subunit alpha type-1

1

1

High-throughput

0.515

High

645123

PSB4
Proteasome subunit beta type-4

1

3

High-throughput

0.515

High

660828

PSA2
Proteasome subunit alpha type-2

1

1

High-throughput

0.515

High

660829

PSB6
Proteasome subunit beta type-6

1

1

High-throughput

0.515

High

660831

PSB2
Proteasome subunit beta type-2

1

1

High-throughput

0.515

High

660833

PSB3
Proteasome subunit beta type-3

1

2

High-throughput

0.515

High

660837

PSB5
Proteasome subunit beta type-5

1

2

High-throughput

0.515

High

660838

PSB7
Proteasome subunit beta type-7

1

2

High-throughput

0.515

High

660840

PSA5
Proteasome subunit alpha type-5

1

1

High-throughput

0.515

High

660859

PSA6
Proteasome subunit alpha type-6

1

1

High-throughput

0.515

High

660860

PSA4
Proteasome subunit alpha type-4

1

1

High-throughput

0.515

High

660875

ERG13
Hydroxymethylglutaryl-CoA synthase

1

1

High-throughput

0.515

High

660852

RPB11
DNA-directed RNA polymerase II subunit RPB11

1

0

High-throughput

0.513

High

660864

MKT1
Post-transcriptional regulator MKT1

1

0

High-throughput

0.513

High

479250

CDC6
Cell division control protein 6

1

1

Small-scale

0.501

High

486757

CDC16
Anaphase-promoting complex subunit CDC16

1

8

Small-scale

0.501

High

509408

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

15

High-throughput

0.501

High

517905

SSBP1
Single-stranded nucleic acid-binding protein

1

9

High-throughput

0.501

High

660830

MPIP
M-phase inducer phosphatase

1

1

Small-scale

0.501

High

660842

CDC13
Cell division control protein 13

1

1

Small-scale

0.501

High

660851

DNA2
DNA replication ATP-dependent helicase/nuclease DNA2 [Includes: DNA replication nuclease DNA2

1

2

Small-scale

0.501

High

660872

APC1
Anaphase-promoting complex subunit 1

1

2

Small-scale

0.501

High

660877

ESP1
Separin

1

2

Small-scale

0.501

High

660886

SCC1
Sister chromatid cohesion protein 1

1

3

Small-scale

0.501

High

405034

LEU3
3-isopropylmalate dehydrogenase

1

4

High-throughput

0.500

High

453432

PYR1
Multifunctional protein URA2

1

5

High-throughput

0.500

High

470466

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

5

High-throughput

0.500

High

598958

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

5

High-throughput

0.500

High

660827

PSA3
Proteasome subunit alpha type-3

1

0

High-throughput

0.493

High

660845

T2EA
Transcription initiation factor IIE subunit alpha

1

0

High-throughput

0.493

High

660846

T2EB
Transcription initiation factor IIE subunit beta

1

0

High-throughput

0.493

High

660850

PPME1
Protein phosphatase methylesterase 1

1

4

High-throughput

0.489

High

660849

PP4R2
Serine/threonine-protein phosphatase 4 regulatory subunit 2

1

0

Small-scale

0.480

High

486042

TBA1
Tubulin alpha-1 chain

1

8

High-throughput

0.479

High

660836

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

660844

DEF1
RNA polymerase II degradation factor 1

1

4

High-throughput

0.479

High

660868

MOG1
Nuclear import protein MOG1

1

1

High-throughput

0.479

High

660879

SIZ1
E3 SUMO-protein ligase SIZ1

1

7

High-throughput

0.479

High

660883

ULA1
NEDD8-activating enzyme E1 regulatory subunit

1

2

High-throughput

0.470

High

602111

SPO12
Sporulation-specific protein 12

1

0

High-throughput

0.460

High

638026

UTR1
NAD(+) kinase

1

0

High-throughput

0.458

High

660862

ULP2
Ubiquitin-like-specific protease 2

1

0

High-throughput

0.458

High

660863

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

660885

APC9
Anaphase-promoting complex subunit 9

1

1

Small-scale

0.457

High

585531

BGL2
Glucan 1,3-beta-glucosidase

1

1

High-throughput

0.457

High

660867

TCPQ
T-complex protein 1 subunit theta

1

20

High-throughput

0.457

High

660888

HSP42
Heat shock protein 42

1

2

High-throughput

0.457

High

481490

HSP73
Heat shock protein SSA3

1

15

High-throughput

0.445

High

523111

HSP71
Heat shock protein SSA1

1

15

High-throughput

0.445

High

543874

SSB1
Ribosome-associated molecular chaperone SSB1

1

17

High-throughput

0.445

High

660835

SPB4
ATP-dependent rRNA helicase SPB4

1

5

High-throughput

0.437

High

660854

TCPB
T-complex protein 1 subunit beta

1

20

High-throughput

0.437

High

660855

TCPG
T-complex protein 1 subunit gamma

1

20

High-throughput

0.437

High

660865

TCPH
T-complex protein 1 subunit eta

1

20

High-throughput

0.437

High

660881

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.437

High

660884

YG11A
Transposon Ty1-GR1 Gag polyprotein

1

1

High-throughput

0.437

High

660889

DBP10
ATP-dependent RNA helicase DBP10

1

7

High-throughput

0.437

High

660857

HSP7E
Heat shock protein SSC3, mitochondrial

1

19

High-throughput

0.407

High

660870

GPG1
Heterotrimeric G protein gamma subunit GPG1

1

0

High-throughput

0.279

Low

660861

MPM1
Mitochondrial peculiar membrane protein 1

1

0

High-throughput

0.261

Low

660856

AIM2
Protein AIM2

1

0

High-throughput

0.249

Low

660866

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025