HitPredict

Interactor 1: TRAF6 (P70196)
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (RING-type E3 ubiquitin transferase TRAF6)
Gene: TRAF6

Interactor 2: TRAF3 (Q60803)
TNF receptor-associated factor 3 (EC 2.3.2.27) (CD40 receptor-associated factor 1) (CRAF1) (CD40-binding protein) (CD40BP) (RING-type E3 ubiquitin transferase TRAF3)
Gene: TRAF3

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.38 1.00 0.618

The method score is based on:

Property Details
Experiments 26474655
Identification Methods affinity chromatography technology
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains TRAF-mep_MATH~TRAF-mep_MATH
Common GO terms GO:0005164 - tumor necrosis factor receptor binding
GO:0008270 - zinc ion binding
GO:0009898 - cytoplasmic side of plasma membrane
GO:0032481 - positive regulation of type I interferon production
GO:0033209 - tumor necrosis factor-mediated signaling pathway
and 4 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 530
Mm

1 567
+ Hs
+ Hs
+ Mm
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Mm
+ Mm
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 11Aug2025