Protein: GGYF1
GRB10-interacting GYF protein 1 (PERQ amino acid-rich with GYF domain-containing protein 1)

Gene: GGYF1, GIGYF1
Organism: Homo sapiens
Interactions: 210
UniProt ID: O75420

Gene Ontology (top 5):
GO:0005829 - cytosol
GO:0032991 - protein-containing complex
GO:0048009 - insulin-like growth factor receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

281350

GGYF2
GRB10-interacting GYF protein 2

2

13

High-throughput

0.789

High

251990

IF4E2
Eukaryotic translation initiation factor 4E type 2

8

9

Small-scale

0.755

High

281303

1433G
14-3-3 protein gamma

4

20

High-throughput

0.699

High

281309

1433F
14-3-3 protein eta

4

20

High-throughput

0.699

High

281284

DDX6
Probable ATP-dependent RNA helicase DDX6

4

2

High-throughput

0.692

High

281363

ZN598
E3 ubiquitin-protein ligase ZNF598

4

5

Small-scale

0.686

High

281395

STAC3
SH3 and cysteine-rich domain-containing protein 3

3

13

High-throughput

0.665

High

281289

1433B
14-3-3 protein beta/alpha

3

20

High-throughput

0.662

High

281316

GRB10
Growth factor receptor-bound protein 10

3

11

Small-scale

0.661

High

281385

CNOT9
CCR4-NOT transcription complex subunit 9

2

2

Small-scale

0.624

High

281281

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

2

2

High-throughput

0.606

High

281299

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

2

1

High-throughput

0.606

High

281399

SPAG8
Sperm-associated antigen 8

2

1

High-throughput

0.606

High

281423

NEK6
Serine/threonine-protein kinase Nek6

2

4

High-throughput

0.606

High

281285

TTP
mRNA decay activator protein ZFP36

2

2

Small-scale

0.584

High

281374

MNS1
Meiosis-specific nuclear structural protein 1

2

0

High-throughput

0.580

High

281388

KAT5
Histone acetyltransferase KAT5

2

0

High-throughput

0.580

High

281434

AIRIM
AFG2-interacting ribosome maturation factor

2

0

High-throughput

0.580

High

281404

WDR83
WD repeat domain-containing protein 83

2

7

High-throughput

0.574

High

281286

1433T
14-3-3 protein theta

2

20

Small-scale

0.571

High

281375

NAV1
Neuron navigator 1

2

7

High-throughput

0.558

High

281278

SNRPA
U1 small nuclear ribonucleoprotein A

2

2

High-throughput

0.553

High

281279

RU1C
U1 small nuclear ribonucleoprotein C

2

1

High-throughput

0.553

High

281331

CCD57
Coiled-coil domain-containing protein 57

2

6

High-throughput

0.553

High

281377

IKBD
NF-kappa-B inhibitor delta

2

6

High-throughput

0.553

High

281392

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

2

3

High-throughput

0.553

High

281406

EFC4B
EF-hand calcium-binding domain-containing protein 4B

2

5

High-throughput

0.553

High

281408

KIFC3
Kinesin-like protein KIFC3

2

5

High-throughput

0.553

High

281430

TSH2
Teashirt homolog 2

2

3

High-throughput

0.553

High

281433

RBM22
Pre-mRNA-splicing factor RBM22

2

1

High-throughput

0.553

High

281437

ANR10
Ankyrin repeat domain-containing protein 10

2

5

High-throughput

0.553

High

281457

SCAF8
SR-related and CTD-associated factor 8

2

2

High-throughput

0.553

High

156577

DC1I1
Cytoplasmic dynein 1 intermediate chain 1

1

10

High-throughput

0.536

High

187835

EIF3H
Eukaryotic translation initiation factor 3 subunit H

1

4

High-throughput

0.536

High

210514

DC1L2
Cytoplasmic dynein 1 light intermediate chain 2

1

3

High-throughput

0.536

High

281283

DNJB1
DnaJ homolog subfamily B member 1

1

2

High-throughput

0.536

High

281292

LONM
Lon protease homolog, mitochondrial

1

8

High-throughput

0.536

High

281293

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

1

5

High-throughput

0.536

High

281294

MAP1B
Microtubule-associated protein 1B

1

8

High-throughput

0.536

High

281296

AL7A1
Alpha-aminoadipic semialdehyde dehydrogenase

1

2

High-throughput

0.536

High

281297

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

4

High-throughput

0.536

High

281304

1433E
14-3-3 protein epsilon

1

3

High-throughput

0.536

High

281305

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.536

High

281306

PA1B2
Platelet-activating factor acetylhydrolase IB subunit alpha2

1

1

High-throughput

0.536

High

281308

ANK2
Ankyrin-2

1

7

High-throughput

0.536

High

281317

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

1

6

High-throughput

0.536

High

281318

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

9

High-throughput

0.536

High

281320

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

4

High-throughput

0.536

High

281325

PA1B3
Platelet-activating factor acetylhydrolase IB subunit alpha1

1

1

High-throughput

0.536

High

281329

TRXR1
Thioredoxin reductase 1, cytoplasmic

1

1

High-throughput

0.536

High

281340

MAP1S
Microtubule-associated protein 1S

1

6

High-throughput

0.536

High

281378

SMRC2
SWI/SNF complex subunit SMARCC2

1

7

High-throughput

0.536

High

281413

NDEL1
Nuclear distribution protein nudE-like 1

1

6

High-throughput

0.536

High

281439

ARHGC
Rho guanine nucleotide exchange factor 12

1

7

High-throughput

0.536

High

281446

DNJB4
DnaJ homolog subfamily B member 4

1

2

High-throughput

0.536

High

281450

FEM1B
Protein fem-1 homolog B

1

6

High-throughput

0.536

High

281466

DC1L1
Cytoplasmic dynein 1 light intermediate chain 1

1

3

High-throughput

0.536

High

281371

RN214
RING finger protein 214

2

2

High-throughput

0.535

High

281302

SNP25
Synaptosomal-associated protein 25

1

0

High-throughput

0.513

High

281312

WASC5
WASH complex subunit 5

1

0

High-throughput

0.513

High

281338

WAC2A
WASH complex subunit 2A

1

0

High-throughput

0.513

High

281366

MMAA
Methylmalonic aciduria type A protein, mitochondrial

1

0

High-throughput

0.513

High

281417

MMAD
Cobalamin trafficking protein CblD

1

0

High-throughput

0.513

High

281277

IF4E
Eukaryotic translation initiation factor 4E

1

9

Small-scale

0.501

High

219771

KCNQ2
Potassium voltage-gated channel subfamily KQT member 2

1

2

High-throughput

0.489

High

281348

KLD10
Kelch domain-containing protein 10

1

6

High-throughput

0.489

High

281355

MTSS2
Protein MTSS 2

1

3

High-throughput

0.489

High

281365

RB6I2
ELKS/Rab6-interacting/CAST family member 1

1

10

High-throughput

0.489

High

281387

KCNB2
Potassium voltage-gated channel subfamily B member 2

1

2

High-throughput

0.489

High

281416

WDR13
WD repeat-containing protein 13

1

7

High-throughput

0.489

High

281321

GRB14
Growth factor receptor-bound protein 14

1

11

Small-scale

0.481

High

281322

GRB7
Growth factor receptor-bound protein 7

1

11

Small-scale

0.481

High

172329

XPO1
Exportin-1

1

7

High-throughput

0.479

High

176432

GRRE1
Granule associated Rac and RHOG effector protein 1

1

1

High-throughput

0.479

High

269489

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

6

High-throughput

0.479

High

281273

OFD1
Centriole and centriolar satellite protein OFD1

1

1

High-throughput

0.479

High

281274

TRI37
E3 ubiquitin-protein ligase TRIM37

1

12

High-throughput

0.479

High

281275

NADK
NAD kinase

1

3

High-throughput

0.479

High

281282

NF1
Neurofibromin

1

4

High-throughput

0.479

High

281287

MPIP2
M-phase inducer phosphatase 2

1

2

High-throughput

0.479

High

281288

MPIP3
M-phase inducer phosphatase 3

1

2

High-throughput

0.479

High

281290

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

281300

AFAD
Afadin

1

11

High-throughput

0.479

High

281301

HDAC4
Histone deacetylase 4

1

8

High-throughput

0.479

High

281307

CDK16
Cyclin-dependent kinase 16

1

3

High-throughput

0.479

High

281311

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

11

High-throughput

0.479

High

281315

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

9

High-throughput

0.479

High

281334

ODFP2
Outer dense fiber protein 2

1

4

High-throughput

0.479

High

281336

SPD2A
SH3 and PX domain-containing protein 2A

1

9

High-throughput

0.479

High

281337

DEN4C
DENN domain-containing protein 4C

1

5

High-throughput

0.479

High

281339

CP135
Centrosomal protein of 135 kDa

1

7

High-throughput

0.479

High

281341

A16L1
Autophagy-related protein 16-1

1

7

High-throughput

0.479

High

281345

PKHA7
Pleckstrin homology domain-containing family A member 7

1

13

High-throughput

0.479

High

281347

CEP85
Centrosomal protein of 85 kDa

1

14

High-throughput

0.479

High

281349

LARP1
La-related protein 1

1

2

High-throughput

0.479

High

281352

MEX3B
RNA-binding protein MEX3B

1

1

High-throughput

0.479

High

281357

MYCPP
C-myc promoter-binding protein

1

5

High-throughput

0.479

High

281359

YTHD3
YTH domain-containing family protein 3

1

7

High-throughput

0.479

High

281360

PHLB2
Pleckstrin homology-like domain family B member 2

1

13

High-throughput

0.479

High

281361

PATL1
Protein PAT1 homolog 1

1

3

High-throughput

0.479

High

281367

KSR1
Kinase suppressor of Ras 1

1

4

High-throughput

0.479

High

281369

RPTOR
Regulatory-associated protein of mTOR

1

6

High-throughput

0.479

High

281370

CNTRB
Centrobin

1

4

High-throughput

0.479

High

281372

LS14A
Protein LSM14 homolog A

1

3

High-throughput

0.479

High

281373

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

6

High-throughput

0.479

High

281379

F110B
Protein FAM110B

1

1

High-throughput

0.479

High

281380

DEN1A
DENN domain-containing protein 1A

1

5

High-throughput

0.479

High

281382

HDAC7
Histone deacetylase 7

1

8

High-throughput

0.479

High

281391

EDC3
Enhancer of mRNA-decapping protein 3

1

1

High-throughput

0.479

High

281394

SNX27
Sorting nexin-27

1

5

High-throughput

0.479

High

281400

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

1

High-throughput

0.479

High

281401

F110A
Protein FAM110A

1

1

High-throughput

0.479

High

281403

LZTS2
Leucine zipper putative tumor suppressor 2

1

11

High-throughput

0.479

High

281405

RTKN
Rhotekin

1

1

High-throughput

0.479

High

281407

CP250
Centrosome-associated protein CEP250

1

9

High-throughput

0.479

High

281411

CPEB1
Cytoplasmic polyadenylation element-binding protein 1

1

2

High-throughput

0.479

High

281412

OSBL6
Oxysterol-binding protein-related protein 6

1

2

High-throughput

0.479

High

281420

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

281421

PKHA5
Pleckstrin homology domain-containing family A member 5

1

15

High-throughput

0.479

High

281425

MOV10
Helicase MOV-10

1

2

High-throughput

0.479

High

281426

TNR6C
Trinucleotide repeat-containing gene 6C protein

1

9

High-throughput

0.479

High

281428

ANLN
Anillin

1

4

High-throughput

0.479

High

281431

LATS2
Serine/threonine-protein kinase LATS2

1

6

High-throughput

0.479

High

281432

INP5E
Phosphatidylinositol polyphosphate 5-phosphatase type IV

1

4

High-throughput

0.479

High

281440

CNOT2
CCR4-NOT transcription complex subunit 2

1

5

High-throughput

0.479

High

281447

LIMA1
LIM domain and actin-binding protein 1

1

3

High-throughput

0.479

High

281449

NGAP
Ras GTPase-activating protein nGAP

1

4

High-throughput

0.479

High

281451

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

2

High-throughput

0.479

High

281452

AGO2
Protein argonaute-2

1

2

High-throughput

0.479

High

281454

ZBT21
Zinc finger and BTB domain-containing protein 21

1

2

High-throughput

0.479

High

281459

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

5

High-throughput

0.479

High

281460

GAB2
GRB2-associated-binding protein 2

1

5

High-throughput

0.479

High

281461

NINL
Ninein-like protein

1

13

High-throughput

0.479

High

281462

CBY1
Protein chibby homolog 1

1

1

High-throughput

0.479

High

281463

STA13
StAR-related lipid transfer protein 13

1

9

High-throughput

0.479

High

281465

YTHD2
YTH domain-containing family protein 2

1

8

High-throughput

0.479

High

281298

ATN1
Atrophin-1

1

3

High-throughput

0.464

High

163023

CHK1
Serine/threonine-protein kinase Chk1

1

0

High-throughput

0.458

High

281295

KC1A
Casein kinase I isoform alpha

1

0

High-throughput

0.458

High

281376

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

281410

PANK2
Pantothenate kinase 2, mitochondrial

1

0

High-throughput

0.458

High

281429

4ET
Eukaryotic translation initiation factor 4E transporter

1

0

High-throughput

0.458

High

281453

BRPF3
Bromodomain and PHD finger-containing protein 3

1

0

High-throughput

0.458

High

104959

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

174467

TRI66
Tripartite motif-containing protein 66

1

8

High-throughput

0.437

High

176790

DCLK1
Serine/threonine-protein kinase DCLK1

1

5

High-throughput

0.437

High

208607

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

3

High-throughput

0.437

High

230489

KIF1C
Kinesin-like protein KIF1C

1

8

High-throughput

0.437

High

245185

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

5

High-throughput

0.437

High

245828

KIF1B
Kinesin-like protein KIF1B

1

8

High-throughput

0.437

High

281314

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

5

High-throughput

0.437

High

281319

UBP2L
Ubiquitin-associated protein 2-like

1

3

High-throughput

0.437

High

281323

MELK
Maternal embryonic leucine zipper kinase

1

2

High-throughput

0.437

High

281324

ZN638
Zinc finger protein 638

1

1

High-throughput

0.437

High

281327

PTN14
Tyrosine-protein phosphatase non-receptor type 14

1

6

High-throughput

0.437

High

281330

CPEB4
Cytoplasmic polyadenylation element-binding protein 4

1

3

High-throughput

0.437

High

281332

TBC25
TBC1 domain family member 25

1

3

High-throughput

0.437

High

281333

CRTC2
CREB-regulated transcription coactivator 2

1

1

High-throughput

0.437

High

281335

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

1

High-throughput

0.437

High

281342

RNF43
E3 ubiquitin-protein ligase RNF43

1

2

High-throughput

0.437

High

281343

AN34A
Ankyrin repeat domain-containing protein 34A

1

9

High-throughput

0.437

High

281351

SYNE3
Nesprin-3

1

11

High-throughput

0.437

High

281353

CE128
Centrosomal protein of 128 kDa

1

11

High-throughput

0.437

High

281354

SYDE1
Rho GTPase-activating protein SYDE1

1

9

High-throughput

0.437

High

281356

RFIP2
Rab11 family-interacting protein 2

1

1

High-throughput

0.437

High

281364

RGPS2
Ras-specific guanine nucleotide-releasing factor RalGPS2

1

4

High-throughput

0.437

High

281368

Z3H7A
Zinc finger CCCH domain-containing protein 7A

1

6

High-throughput

0.437

High

281381

SH3R3
E3 ubiquitin-protein ligase SH3RF3

1

10

High-throughput

0.437

High

281383

DEP1B
DEP domain-containing protein 1B

1

4

High-throughput

0.437

High

281384

SRS12
Serine/arginine-rich splicing factor 12

1

2

High-throughput

0.437

High

281393

FUBP3
Far upstream element-binding protein 3

1

6

High-throughput

0.437

High

281396

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

8

High-throughput

0.437

High

281397

TESK2
Dual specificity testis-specific protein kinase 2

1

1

High-throughput

0.437

High

281402

LPIN3
Phosphatidate phosphatase LPIN3

1

1

High-throughput

0.437

High

281424

TANC2
Protein TANC2

1

9

High-throughput

0.437

High

281427

KI13B
Kinesin-like protein KIF13B

1

8

High-throughput

0.437

High

281442

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

1

High-throughput

0.437

High

281444

CING
Cingulin

1

3

High-throughput

0.437

High

281448

XPO7
Exportin-7

1

6

High-throughput

0.437

High

281455

PPM1H
Protein phosphatase 1H

1

1

High-throughput

0.437

High

281458

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

1

High-throughput

0.437

High

281464

KCTD3
BTB/POZ domain-containing protein KCTD3

1

3

High-throughput

0.437

High

281344

MRM1
rRNA methyltransferase 1, mitochondrial

1

1

High-throughput

0.407

High

281386

ESR2
Estrogen receptor beta

1

4

High-throughput

0.407

High

281280

PRR35
Proline-rich protein 35

2

0

High-throughput

0.316

High

281310

TLE5
TLE family member 5

2

0

High-throughput

0.316

High

281313

TROAP
Tastin

2

0

High-throughput

0.316

High

281326

TCEA2
Transcription elongation factor A protein 2

2

0

High-throughput

0.316

High

281390

MCRS1
Microspherule protein 1

2

0

High-throughput

0.316

High

281409

SCNM1
Sodium channel modifier 1

2

0

High-throughput

0.316

High

281415

ENKD1
Enkurin domain-containing protein 1

2

0

High-throughput

0.316

High

281418

F124B
Protein FAM124B

2

0

High-throughput

0.316

High

281419

ARMC7
Armadillo repeat-containing protein 7

2

0

High-throughput

0.316

High

281422

CBX8
Chromobox protein homolog 8

2

0

High-throughput

0.316

High

281291

DUT
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial

1

0

High-throughput

0.279

Low

281328

NSDHL
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

1

0

High-throughput

0.279

Low

281358

SPT19
Spermatogenesis-associated protein 19, mitochondrial

1

0

High-throughput

0.279

Low

281398

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

0

High-throughput

0.279

Low

281443

RELCH
RAB11-binding protein RELCH

1

0

High-throughput

0.279

Low

281445

GABR1
Gamma-aminobutyric acid type B receptor subunit 1

1

0

High-throughput

0.279

Low

281456

SYNRG
Synergin gamma

1

0

High-throughput

0.279

Low

281346

REEP3
Receptor expression-enhancing protein 3

1

0

High-throughput

0.249

Low

281362

TBCD1
TBC1 domain family member 1

1

0

High-throughput

0.249

Low

281389

DACT3
Dapper homolog 3

1

0

High-throughput

0.249

Low

281414

MFR1L
Mitochondrial fission regulator 1-like

1

0

High-throughput

0.249

Low

281435

F120C
Constitutive coactivator of PPAR-gamma-like protein 2

1

0

High-throughput

0.249

Low

281436

CWC25
Pre-mRNA-splicing factor CWC25 homolog

1

0

High-throughput

0.249

Low

281438

FA53C
Protein FAM53C

1

0

High-throughput

0.249

Low

281441

SH3B4
SH3 domain-binding protein 4

1

0

High-throughput

0.249

Low

281276

KV133
Immunoglobulin kappa variable 1-33

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025