Protein: RYK
Tyrosine-protein kinase RYK (EC 2.7.10.1)

Gene: RYK
Organism: Homo sapiens
Interactions: 199
UniProt ID: P34925

Gene Ontology (top 5):
GO:0004672 - protein kinase activity
GO:0004888 - transmembrane signaling receptor activity
GO:0005109 - frizzled binding
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

713834

AGRA3
Adhesion G protein-coupled receptor A3

3

20

Small-scale

0.861

High

713807

EPHA7
Ephrin type-A receptor 7

2

20

High-throughput

0.798

High

489910

PTPRF
Receptor-type tyrosine-protein phosphatase F

2

20

Small-scale

0.789

High

665155

EPHA2
Ephrin type-A receptor 2

2

20

High-throughput

0.789

High

713776

EPHA4
Ephrin type-A receptor 4

2

20

Small-scale

0.789

High

713796

PTK7
Inactive tyrosine-protein kinase 7

2

18

Small-scale

0.789

High

713797

PTPRS
Receptor-type tyrosine-protein phosphatase S

2

20

Small-scale

0.789

High

713825

FAT4
Protocadherin Fat 4

2

18

Small-scale

0.789

High

713863

AGRA2
Adhesion G protein-coupled receptor A2

2

20

Small-scale

0.789

High

713850

FAT3
Protocadherin Fat 3

2

20

Small-scale

0.705

High

713805

PTPRR
Receptor-type tyrosine-protein phosphatase R

1

20

High-throughput

0.698

High

713823

NR3L1
Natural cytotoxicity triggering receptor 3 ligand 1

4

20

Small-scale

0.696

High

441446

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.691

High

530154

NCAM1
Neural cell adhesion molecule 1

1

19

High-throughput

0.691

High

576991

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

1

20

High-throughput

0.691

High

601472

FGFR2
Fibroblast growth factor receptor 2

1

16

High-throughput

0.691

High

607899

FGFR4
Fibroblast growth factor receptor 4

1

16

High-throughput

0.691

High

616946

PTPRD
Receptor-type tyrosine-protein phosphatase delta

1

20

High-throughput

0.691

High

713769

KC1E
Casein kinase I isoform epsilon

1

19

High-throughput

0.691

High

713775

EPHB4
Ephrin type-B receptor 4

1

20

High-throughput

0.691

High

713785

ROR1
Inactive tyrosine-protein kinase transmembrane receptor ROR1

1

19

High-throughput

0.691

High

713792

CNTN1
Contactin-1

1

12

High-throughput

0.691

High

713798

PLD1
Phospholipase D1

1

2

High-throughput

0.691

High

713806

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

1

20

High-throughput

0.691

High

713813

PRTG
Protogenin

1

20

High-throughput

0.691

High

713816

CDON
Cell adhesion molecule-related/down-regulated by oncogenes

1

20

High-throughput

0.691

High

713818

SDK2
Protein sidekick-2

1

20

High-throughput

0.691

High

713829

SDK1
Protein sidekick-1

1

20

High-throughput

0.691

High

713851

IGDC4
Immunoglobulin superfamily DCC subclass member 4

1

20

High-throughput

0.691

High

713852

LRC15
Leucine-rich repeat-containing protein 15

1

20

High-throughput

0.691

High

713859

NEO1
Neogenin

1

20

High-throughput

0.691

High

713878

LRC4B
Leucine-rich repeat-containing protein 4B

1

20

High-throughput

0.691

High

713810

CDC37
Hsp90 co-chaperone Cdc37

3

18

Small-scale

0.667

High

713812

MICA
MHC class I polypeptide-related sequence A

3

17

High-throughput

0.667

High

713814

CEA21
Carcinoembryonic antigen-related cell adhesion molecule 21

3

13

High-throughput

0.667

High

225550

PCDH7
Protocadherin-7

3

20

Small-scale

0.660

High

713833

MIB1
E3 ubiquitin-protein ligase MIB1

3

19

Small-scale

0.656

High

411319

INSR
Insulin receptor

1

19

High-throughput

0.646

High

545076

PVR
Poliovirus receptor

2

18

High-throughput

0.628

High

713830

MILR1
Allergin-1

2

20

High-throughput

0.628

High

713841

SIGL1
SIGLEC family-like protein 1

2

1

High-throughput

0.628

High

713849

RAE1E
Retinoic acid early transcript 1E

2

20

High-throughput

0.628

High

713896

PCDGH
Protocadherin gamma-B5

2

20

High-throughput

0.618

High

277014

STAM2
Signal transducing adapter molecule 2

1

20

High-throughput

0.618

High

414781

CDK1
Cyclin-dependent kinase 1

1

20

Small-scale

0.618

High

647483

MK03
Mitogen-activated protein kinase 3

1

9

Small-scale

0.618

High

658810

MK01
Mitogen-activated protein kinase 1

1

9

Small-scale

0.618

High

665552

EPHB2
Ephrin type-B receptor 2

1

20

Small-scale

0.618

High

713774

EPHB3
Ephrin type-B receptor 3

1

20

Small-scale

0.618

High

713787

DYST
Dystonin

1

20

High-throughput

0.618

High

713788

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

20

High-throughput

0.618

High

713837

ABI1
Abl interactor 1

1

20

Small-scale

0.618

High

713889

PACN2
Protein kinase C and casein kinase substrate in neurons protein 2

1

20

High-throughput

0.618

High

234422

NRP2
Neuropilin-2

2

8

Small-scale

0.611

High

280214

CBPD
Carboxypeptidase D

2

8

High-throughput

0.611

High

713820

FREM2
FRAS1-related extracellular matrix protein 2

2

14

Small-scale

0.611

High

713822

CD276
CD276 antigen

2

20

Small-scale

0.611

High

713862

PCD16
Protocadherin-16

2

20

Small-scale

0.611

High

713871

PCDH9
Protocadherin-9

2

20

Small-scale

0.611

High

713873

CELR2
Cadherin EGF LAG seven-pass G-type receptor 2

2

19

Small-scale

0.611

High

713880

CELR1
Cadherin EGF LAG seven-pass G-type receptor 1

2

20

Small-scale

0.611

High

713881

CELR3
Cadherin EGF LAG seven-pass G-type receptor 3

2

20

Small-scale

0.611

High

713885

S53A1
Solute carrier family 53 member 1

2

3

High-throughput

0.611

High

713887

KDIS
Kinase D-interacting substrate of 220 kDa

2

17

High-throughput

0.611

High

713900

PCDGB
Protocadherin gamma-A11

2

18

Small-scale

0.611

High

702330

TNFL8
Tumor necrosis factor ligand superfamily member 8

2

0

High-throughput

0.602

High

382324

HLAA
HLA class I histocompatibility antigen, A alpha chain

2

15

High-throughput

0.601

High

713804

DSC3
Desmocollin-3

2

20

Small-scale

0.594

High

713763

CTNB1
Catenin beta-1

2

20

Small-scale

0.584

High

713786

DSC2
Desmocollin-2

2

20

Small-scale

0.584

High

713802

DSG2
Desmoglein-2

2

20

Small-scale

0.584

High

713827

S39A5
Zinc transporter ZIP5

2

6

High-throughput

0.574

High

713861

CDHR1
Cadherin-related family member 1

2

20

Small-scale

0.558

High

273378

PPM1B
Protein phosphatase 1B

1

6

High-throughput

0.541

High

713791

PP2BA
Protein phosphatase 3 catalytic subunit alpha

1

9

High-throughput

0.541

High

154315

TR10B
Tumor necrosis factor receptor superfamily member 10B

1

17

High-throughput

0.536

High

155284

NRP1
Neuropilin-1

1

8

High-throughput

0.536

High

231356

PCDGC
Protocadherin gamma-A12

1

20

High-throughput

0.536

High

253454

PLXA2
Plexin-A2

1

20

High-throughput

0.536

High

304923

DUS14
Dual specificity protein phosphatase 14

1

19

High-throughput

0.536

High

396694

S10A8
Protein S100-A8

1

7

High-throughput

0.536

High

518557

FA5
Coagulation factor V

1

11

High-throughput

0.536

High

528658

CFTR
Cystic fibrosis transmembrane conductance regulator

1

8

High-throughput

0.536

High

546436

INGR1
Interferon gamma receptor 1

1

7

High-throughput

0.536

High

640704

CTNA2
Catenin alpha-2

1

15

High-throughput

0.536

High

702743

CADH5
Cadherin-5

1

20

High-throughput

0.536

High

713767

HSP13
Heat shock 70 kDa protein 13

1

14

High-throughput

0.536

High

713768

PTH2R
Parathyroid hormone 2 receptor

1

12

High-throughput

0.536

High

713772

BCAM
Basal cell adhesion molecule

1

20

High-throughput

0.536

High

713779

ACTA
Actin, aortic smooth muscle

1

8

High-throughput

0.536

High

713780

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

14

High-throughput

0.536

High

713783

EFNB1
Ephrin-B1

1

12

High-throughput

0.536

High

713790

PCDH1
Protocadherin-1

1

20

High-throughput

0.536

High

713794

ANK3
Ankyrin-3

1

12

High-throughput

0.536

High

713800

CD166
CD166 antigen

1

20

High-throughput

0.536

High

713801

DAG1
Dystroglycan 1

1

9

High-throughput

0.536

High

713809

EFNB3
Ephrin-B3

1

12

High-throughput

0.536

High

713811

MICB
MHC class I polypeptide-related sequence B

1

17

High-throughput

0.536

High

713819

TTMP
TPA-induced transmembrane protein

1

1

High-throughput

0.536

High

713824

CSPG4
Chondroitin sulfate proteoglycan 4

1

14

High-throughput

0.536

High

713826

KAT3
Kynurenine--oxoglutarate transaminase 3

1

2

High-throughput

0.536

High

713831

DSG4
Desmoglein-4

1

20

High-throughput

0.536

High

713842

DCBD1
Discoidin, CUB and LCCL domain-containing protein 1

1

7

High-throughput

0.536

High

713845

NLGN2
Neuroligin-2

1

1

High-throughput

0.536

High

713847

PCD19
Protocadherin-19

1

20

High-throughput

0.536

High

713855

YLAT2
Y+L amino acid transporter 2

1

7

High-throughput

0.536

High

713858

NECT2
Nectin-2

1

20

High-throughput

0.536

High

713860

KIRR1
Kin of IRRE-like protein 1

1

20

High-throughput

0.536

High

713865

TRPM7
Transient receptor potential cation channel subfamily M member 7

1

2

High-throughput

0.536

High

713866

PKP4
Plakophilin-4

1

20

High-throughput

0.536

High

713868

ULBP3
UL16-binding protein 3

1

20

High-throughput

0.536

High

713872

PCD18
Protocadherin-18

1

20

High-throughput

0.536

High

713877

CNNM1
Metal transporter CNNM1

1

7

High-throughput

0.536

High

713879

CC50A
Cell cycle control protein 50A

1

5

High-throughput

0.536

High

713882

PDXL2
Podocalyxin-like protein 2

1

6

High-throughput

0.536

High

713884

PCD10
Protocadherin-10

1

20

High-throughput

0.536

High

713888

PCDGK
Protocadherin gamma-C3

1

16

High-throughput

0.536

High

713894

PCDB2
Protocadherin beta-2

1

16

High-throughput

0.536

High

713895

PCDGL
Protocadherin gamma-C4

1

19

High-throughput

0.536

High

713897

PCDG7
Protocadherin gamma-A7

1

18

High-throughput

0.536

High

713898

PCDG6
Protocadherin gamma-A6

1

20

High-throughput

0.536

High

713899

PCDG5
Protocadherin gamma-A5

1

18

High-throughput

0.536

High

207193

SGCE
Epsilon-sarcoglycan

1

0

High-throughput

0.513

High

713765

TNFL9
Tumor necrosis factor ligand superfamily member 9

1

0

High-throughput

0.513

High

713795

SBP1
Methanethiol oxidase

1

0

High-throughput

0.513

High

713836

K319L
Dyslexia-associated protein KIAA0319-like protein

1

0

High-throughput

0.513

High

713848

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.513

High

713854

SCTM1
Secreted and transmembrane protein 1

1

0

High-throughput

0.513

High

416368

S10A9
Protein S100-A9

1

7

High-throughput

0.500

High

500734

CLUS
Clusterin

1

6

High-throughput

0.500

High

523546

XRCC6
X-ray repair cross-complementing protein 6

1

4

High-throughput

0.500

High

524807

XRCC5
X-ray repair cross-complementing protein 5

1

4

High-throughput

0.500

High

713784

TFAM
Transcription factor A, mitochondrial

1

6

High-throughput

0.500

High

713883

CALL5
Calmodulin-like protein 5

1

2

High-throughput

0.500

High

158314

PCD17
Protocadherin-17

1

20

High-throughput

0.489

High

355136

HBD
Hemoglobin subunit delta

1

6

High-throughput

0.489

High

587336

ITIH2
Inter-alpha-trypsin inhibitor heavy chain H2

1

5

High-throughput

0.489

High

713838

PGAM4
Probable phosphoglycerate mutase 4

1

4

High-throughput

0.489

High

608894

SPR2E
Small proline-rich protein 2E

1

0

High-throughput

0.479

High

713773

HMGA2
High mobility group protein HMGI-C

1

0

High-throughput

0.479

High

68146

F1712
Protein FAM171A2

1

18

High-throughput

0.479

High

159908

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

20

High-throughput

0.479

High

168889

ARPC2
Actin-related protein 2/3 complex subunit 2

1

1

High-throughput

0.479

High

325056

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

4

Small-scale

0.479

High

346069

MYC
Myc proto-oncogene protein

1

6

High-throughput

0.479

High

364186

TFR1
Transferrin receptor protein 1

1

8

Small-scale

0.479

High

386198

P53
Cellular tumor antigen p53

1

4

Small-scale

0.479

High

417978

NPM
Nucleophosmin

1

1

Small-scale

0.479

High

443365

VIME
Vimentin

1

8

Small-scale

0.479

High

455140

PARP1
Poly [ADP-ribose] polymerase 1

1

11

Small-scale

0.479

High

475401

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

16

Small-scale

0.479

High

517093

PCNA
Proliferating cell nuclear antigen

1

4

Small-scale

0.479

High

542212

PLAK
Junction plakoglobin

1

20

High-throughput

0.479

High

580205

CADH2
Cadherin-2

1

20

Small-scale

0.479

High

713762

CTNA1
Catenin alpha-1

1

15

Small-scale

0.479

High

713764

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

16

High-throughput

0.479

High

713766

S19A1
Reduced folate transporter

1

1

High-throughput

0.479

High

713770

TMEDA
Transmembrane emp24 domain-containing protein 10

1

7

Small-scale

0.479

High

713771

F10A1
Hsc70-interacting protein

1

19

Small-scale

0.479

High

713778

PSA
Puromycin-sensitive aminopeptidase

1

4

Small-scale

0.479

High

713782

PRKDC
DNA-dependent protein kinase catalytic subunit

1

10

Small-scale

0.479

High

713789

APLP2
Amyloid beta precursor like protein 2

1

10

Small-scale

0.479

High

713793

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

9

Small-scale

0.479

High

713799

PWP1
Periodic tryptophan protein 1 homolog

1

16

High-throughput

0.479

High

713803

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

7

Small-scale

0.479

High

713817

AGK
Acylglycerol kinase, mitochondrial

1

3

Small-scale

0.479

High

713821

F1711
Protein FAM171A1

1

18

High-throughput

0.479

High

713828

CYFP1
Cytoplasmic FMR1-interacting protein 1

1

10

Small-scale

0.479

High

713832

CCD25
Coiled-coil domain-containing protein 25

1

1

High-throughput

0.479

High

713835

MIRO2
Mitochondrial Rho GTPase 2

1

20

Small-scale

0.479

High

713839

NUP93
Nuclear pore complex protein Nup93

1

5

Small-scale

0.479

High

713840

PCD20
Protocadherin-20

1

20

Small-scale

0.479

High

713844

CNNM3
Metal transporter CNNM3

1

7

Small-scale

0.479

High

713846

VANG1
Vang-like protein 1

1

8

High-throughput

0.479

High

713853

FRS2
Fibroblast growth factor receptor substrate 2

1

20

High-throughput

0.479

High

713867

TMM59
Transmembrane protein 59

1

4

Small-scale

0.479

High

713869

GCP60
Golgi resident protein GCP60

1

9

High-throughput

0.479

High

713870

CNNM2
Metal transporter CNNM2

1

7

Small-scale

0.479

High

713874

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

1

20

High-throughput

0.479

High

713876

ITM2C
Integral membrane protein 2C

1

6

Small-scale

0.479

High

713886

MRT4
mRNA turnover protein 4 homolog

1

6

High-throughput

0.479

High

713891

ITM2B
Integral membrane protein 2B

1

6

Small-scale

0.479

High

713893

CHTOP
Chromatin target of PRMT1 protein

1

3

High-throughput

0.479

High

713875

OSGEP
tRNA N6-adenosine threonylcarbamoyltransferase

1

0

Small-scale

0.458

High

68542

NUD19
Acyl-coenzyme A diphosphatase NUDT19

1

3

High-throughput

0.437

High

264683

VP26A
Vacuolar protein sorting-associated protein 26A

1

4

Small-scale

0.437

High

315660

SC24B
Protein transport protein Sec24B

1

20

High-throughput

0.437

High

531743

PDIA4
Protein disulfide-isomerase A4

1

20

High-throughput

0.437

High

713781

NOMO3
BOS complex subunit NOMO3

1

1

Small-scale

0.437

High

713808

SC23A
Protein transport protein Sec23A

1

20

High-throughput

0.437

High

713815

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

6

Small-scale

0.437

High

713843

TXND5
Thioredoxin domain-containing protein 5

1

20

High-throughput

0.437

High

713856

WASF1
Actin-binding protein WASF1

1

20

Small-scale

0.437

High

713857

SEPT8
Septin-8

1

20

High-throughput

0.437

High

713864

VPS35
Vacuolar protein sorting-associated protein 35

1

3

Small-scale

0.437

High

713890

WASF3
Actin-binding protein WASF3

1

20

Small-scale

0.437

High

713892

NCKP1
Nck-associated protein 1

1

2

Small-scale

0.437

High

713901

WASF2
Actin-binding protein WASF2

1

20

Small-scale

0.437

High

713777

MFAP3
Microfibril-associated glycoprotein 3

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024