Protein: ITCH
E3 ubiquitin-protein ligase Itchy (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase Itchy homolog)

Gene: ITCH
Organism: Mus musculus
Interactions: 33
UniProt ID: Q8C863

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0000209 - protein polyubiquitination
GO:0002669 - positive regulation of T cell anergy
GO:0002870 - T cell anergy
GO:0004842 - ubiquitin-protein transferase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

936255

TRAF6
TNF receptor-associated factor 6

4

20

Small-scale

0.694

High

966330

NOTC1
Neurogenic locus notch homolog protein 1

2

15

Small-scale

0.653

High

1112815

TAXB1
Tax1-binding protein 1 homolog

3

8

Small-scale

0.650

High

761828

TRAF2
TNF receptor-associated factor 2

2

13

Small-scale

0.621

High

719315

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

1

Small-scale

0.618

High

1141528

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

2

12

Small-scale

0.601

High

1193463

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

2

2

Small-scale

0.601

High

814020

GLI1
Zinc finger protein GLI1

2

4

Small-scale

0.584

High

1208047

NFIP1
NEDD4 family-interacting protein 1

2

17

Small-scale

0.584

High

1143674

TGFI1
Transforming growth factor beta-1-induced transcript 1 protein

1

9

Small-scale

0.561

High

1143948

SMAD2
Mothers against decapentaplegic homolog 2

1

20

Small-scale

0.561

High

1208046

SHOT1
Shootin-1

1

1

Small-scale

0.561

High

1208051

RNF11
RING finger protein 11

1

14

Small-scale

0.536

High

193424

CFLAR
CASP8 and FADD-like apoptosis regulator

1

3

Small-scale

0.527

High

292676

KLF10
Krueppel-like factor 10

1

6

Small-scale

0.515

High

57546

LRAD3
Low-density lipoprotein receptor class A domain-containing protein 3

1

6

Small-scale

0.479

High

139161

DPYL2
Dihydropyrimidinase-related protein 2

1

8

Small-scale

0.479

High

192337

MCPT9
Mast cell protease 9

1

4

Small-scale

0.479

High

404153

JUN
Transcription factor Jun

1

5

Small-scale

0.479

High

450553

JUNB
Transcription factor JunB

1

5

Small-scale

0.479

High

846441

RORG
Nuclear receptor ROR-gamma

1

8

Small-scale

0.479

High

923900

YBOX1
Y-box-binding protein 1

1

5

Small-scale

0.479

High

936865

CXCR4
C-X-C chemokine receptor type 4

1

5

Small-scale

0.479

High

959812

MCPTX
Mast cell protease-like protein

1

4

Small-scale

0.479

High

1143626

RBP1
RalA-binding protein 1

1

6

Small-scale

0.479

High

1206455

WBP1L
WW domain binding protein 1-like

1

10

Small-scale

0.479

High

1207058

Q8BPK8
Agenet-like domain-containing protein

1

8

High-throughput

0.479

High

1208045

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

3

Small-scale

0.479

High

1208048

MAVS
Mitochondrial antiviral-signaling protein

1

10

Small-scale

0.479

High

1208049

ARRB2
Beta-arrestin-2

1

4

Small-scale

0.479

High

1208050

IFM3
Interferon-induced transmembrane protein 3

1

3

Small-scale

0.479

High

1208052

SUFU
Suppressor of fused homolog

1

1

Small-scale

0.479

High

729556

FMR1
Fragile X messenger ribonucleoprotein 1

1

8

High-throughput

0.445

High


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Last updated: 15 Jul 2024