Protein: TSC1
Hamartin (Tuberous sclerosis 1 protein homolog)

Gene: TSC1
Organism: Mus musculus
Interactions: 124
UniProt ID: Q9EP53

Gene Ontology (top 5):
GO:0001822 - kidney development
GO:0001843 - neural tube closure
GO:0002250 - adaptive immune response
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1222207

TSC2
Tuberin

2

13

Small-scale

0.737

High

1189539

Q3TQ10
TSC complex subunit 2

5

13

Small-scale

0.702

High

1423973

TBCD7
TBC1 domain family member 7

2

2

Small-scale

0.611

High

968213

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

2

16

High-throughput

0.601

High

72844

PTPRS
Receptor-type tyrosine-protein phosphatase S

1

2

High-throughput

0.536

High

73909

PYR1
Multifunctional protein CAD

1

2

High-throughput

0.536

High

104639

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

9

High-throughput

0.536

High

462147

HS90A
Heat shock protein HSP 90-alpha

1

14

High-throughput

0.536

High

528907

IF4A2
Eukaryotic initiation factor 4A-II

1

9

High-throughput

0.536

High

547282

HS90B
Heat shock protein HSP 90-beta

1

14

High-throughput

0.536

High

548972

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

5

High-throughput

0.536

High

704232

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

1

5

High-throughput

0.536

High

704823

KIF5C
Kinesin heavy chain isoform 5C

1

6

High-throughput

0.536

High

746566

RASK
GTPase KRas

1

20

High-throughput

0.536

High

844315

TCPQ
T-complex protein 1 subunit theta

1

8

High-throughput

0.536

High

861898

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

6

High-throughput

0.536

High

884995

CDK5
Cyclin-dependent kinase 5

1

17

High-throughput

0.536

High

901739

RAB7A
Ras-related protein Rab-7a

1

14

High-throughput

0.536

High

945983

EF2
Elongation factor 2

1

6

High-throughput

0.536

High

959457

RAP2B
Ras-related protein Rap-2b

1

10

High-throughput

0.536

High

977646

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

14

High-throughput

0.536

High

981773

RAN
GTP-binding nuclear protein Ran

1

14

High-throughput

0.536

High

988913

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.536

High

989285

HSP7C
Heat shock cognate 71 kDa protein

1

9

High-throughput

0.536

High

989434

DNJA1
DnaJ homolog subfamily A member 1

1

6

High-throughput

0.536

High

990054

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.536

High

993948

KPCG
Protein kinase C gamma type

1

14

High-throughput

0.536

High

993987

PP2BA
Protein phosphatase 3 catalytic subunit alpha

1

17

High-throughput

0.536

High

996087

RACK1
Small ribosomal subunit protein RACK1

1

14

High-throughput

0.536

High

996634

1433T
14-3-3 protein theta

1

20

High-throughput

0.536

High

998190

KPCB
Protein kinase C beta type

1

12

High-throughput

0.536

High

1000350

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

12

High-throughput

0.536

High

1000364

TP53B
TP53-binding protein 1

1

11

High-throughput

0.536

High

1010010

TCPG
T-complex protein 1 subunit gamma

1

5

High-throughput

0.536

High

1013704

TNIK
Traf2 and NCK-interacting protein kinase

1

20

High-throughput

0.536

High

1030286

SC23A
Protein transport protein Sec23A

1

1

High-throughput

0.536

High

1036092

CTNB1
Catenin beta-1

1

12

High-throughput

0.536

High

1041410

EPHA4
Ephrin type-A receptor 4

1

8

High-throughput

0.536

High

1190069

WNK2
Serine/threonine-protein kinase WNK2

1

20

High-throughput

0.536

High

1193949

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

12

High-throughput

0.536

High

1210260

CYFP2
Cytoplasmic FMR1-interacting protein 2

1

1

High-throughput

0.536

High

1221940

ARHG2
Rho guanine nucleotide exchange factor 2

1

12

High-throughput

0.536

High

1222116

FOXG1
Forkhead box protein G1

1

3

High-throughput

0.536

High

1222545

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

20

High-throughput

0.536

High

1222735

RASH
GTPase HRas

1

20

High-throughput

0.536

High

1223092

FXR1
RNA-binding protein FXR1

1

11

High-throughput

0.536

High

1223738

DLG4
Disks large homolog 4

1

9

High-throughput

0.536

High

1224078

TIF1B
Transcription intermediary factor 1-beta

1

16

High-throughput

0.536

High

1244280

TNKS1
Poly [ADP-ribose] polymerase tankyrase-1

1

12

High-throughput

0.536

High

1244509

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

5

High-throughput

0.536

High

1253535

KDM1A
Lysine-specific histone demethylase 1A

1

6

High-throughput

0.536

High

1274217

CYFP1
Cytoplasmic FMR1-interacting protein 1

1

1

High-throughput

0.536

High

1281900

NISCH
Nischarin

1

13

High-throughput

0.536

High

1281942

CLAP1
CLIP-associating protein 1

1

6

High-throughput

0.536

High

1281997

SCRIB
Protein scribble homolog

1

6

High-throughput

0.536

High

1282959

WNK3
Serine/threonine-protein kinase WNK3

1

20

High-throughput

0.536

High

1283522

RHG32
Rho GTPase-activating protein 32

1

9

High-throughput

0.536

High

1297583

TENR
Tenascin-R

1

7

High-throughput

0.536

High

1297646

PAK5
Serine/threonine-protein kinase PAK 5

1

20

High-throughput

0.536

High

1298232

ABI1
Abl interactor 1

1

8

High-throughput

0.536

High

1298458

SMC2
Structural maintenance of chromosomes protein 2

1

11

High-throughput

0.536

High

1317328

MATR3
Matrin-3

1

8

High-throughput

0.536

High

1317366

DP13A
DCC-interacting protein 13-alpha

1

4

High-throughput

0.536

High

1341702

WASF1
Actin-binding protein WASF1

1

11

High-throughput

0.536

High

1354145

SFPQ
Splicing factor, proline- and glutamine-rich

1

14

High-throughput

0.536

High

1362179

RAB14
Ras-related protein Rab-14

1

11

High-throughput

0.536

High

1363064

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

1

5

High-throughput

0.536

High

1423631

LTOR1
Ragulator complex protein LAMTOR1

1

3

High-throughput

0.536

High

1424217

AMPD2
AMP deaminase 2

1

1

High-throughput

0.536

High

1424287

Q9ER67
Melanoma-associated antigen D1

1

11

High-throughput

0.536

High

1424289

LGI1
Leucine-rich glioma-inactivated protein 1

1

5

High-throughput

0.536

High

1424290

CUL3
Cullin-3

1

16

High-throughput

0.536

High

1424291

MINK1
Misshapen-like kinase 1

1

20

High-throughput

0.536

High

1424292

DNJA4
DnaJ homolog subfamily A member 4

1

6

High-throughput

0.536

High

1424293

MAGD1
Melanoma-associated antigen D1

1

10

High-throughput

0.536

High

1424294

DNJA2
DnaJ homolog subfamily A member 2

1

6

High-throughput

0.536

High

1424296

TRIM3
Tripartite motif-containing protein 3

1

15

High-throughput

0.536

High

1424301

RASL1
RasGAP-activating-like protein 1

1

9

High-throughput

0.536

High

683944

EZRI
Ezrin

1

16

Small-scale

0.527

High

683963

RADI
Radixin

1

19

Small-scale

0.527

High

1424298

BEX3
Protein BEX3

1

3

Small-scale

0.515

High

313047

DCX
Neuronal migration protein doublecortin

1

0

High-throughput

0.513

High

704301

NCKP1
Nck-associated protein 1

1

0

High-throughput

0.513

High

840635

PURA
Transcriptional activator protein Pur-alpha

1

0

High-throughput

0.513

High

1058807

MPRI
Cation-independent mannose-6-phosphate receptor

1

0

High-throughput

0.513

High

1208124

CNRP1
CB1 cannabinoid receptor-interacting protein 1

1

0

High-throughput

0.513

High

1237821

FBX41
F-box only protein 41

1

0

High-throughput

0.513

High

1362246

TDRD3
Tudor domain-containing protein 3

1

0

High-throughput

0.513

High

92687

SHAN1
SH3 and multiple ankyrin repeat domains protein 1

1

15

High-throughput

0.500

High

934321

NCAN
Neurocan core protein

1

7

High-throughput

0.489

High

1240010

MTCL3
Microtubule cross-linking factor 3

1

20

High-throughput

0.489

High

1282042

SESD1
SEC14 domain and spectrin repeat-containing protein 1

1

20

High-throughput

0.489

High

1408779

TMED9
Transmembrane emp24 domain-containing protein 9

1

3

High-throughput

0.489

High

1423999

TMEDA
Transmembrane emp24 domain-containing protein 10

1

4

High-throughput

0.489

High

683952

MOES
Moesin

1

19

Small-scale

0.481

High

109323

G5E8T2
E3 ubiquitin-protein ligase TTC3

1

16

High-throughput

0.479

High

728538

AKT1
RAC-alpha serine/threonine-protein kinase

1

14

High-throughput

0.479

High

972314

1433E
14-3-3 protein epsilon

1

8

High-throughput

0.479

High

1022137

DAB2
Disabled homolog 2

1

7

High-throughput

0.479

High

1189128

STING
Stimulator of interferon genes protein

1

4

High-throughput

0.479

High

1242720

Q6P5B5
FMR1 autosomal homolog 2

1

11

High-throughput

0.479

High

1246456

RICTR
Rapamycin-insensitive companion of mTOR

1

5

Small-scale

0.479

High

1296553

WDR48
WD repeat-containing protein 48

1

15

High-throughput

0.479

High

1296811

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

16

High-throughput

0.479

High

1297188

Q8BPK8
Fragile X messenger ribonucleoprotein 1

1

11

High-throughput

0.479

High

1298616

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

3

High-throughput

0.479

High

1424288

RBCC1
RB1-inducible coiled-coil protein 1

1

19

Small-scale

0.479

High

1424299

FOXO3
Forkhead box protein O3

1

9

High-throughput

0.479

High

312004

TTC3
E3 ubiquitin-protein ligase TTC3

1

15

High-throughput

0.445

High

778000

FMR1
Fragile X messenger ribonucleoprotein 1

1

11

High-throughput

0.445

High

1274491

ACTN1
Alpha-actinin-1

1

20

High-throughput

0.445

High

1317439

RPTOR
Regulatory-associated protein of mTOR

1

18

High-throughput

0.445

High

1423749

1433B
14-3-3 protein beta/alpha

1

20

Small-scale

0.445

High

1424295

CELR2
Cadherin EGF LAG seven-pass G-type receptor 2

1

1

High-throughput

0.445

High

1424297

TEN2
Teneurin-2

1

5

High-throughput

0.445

High

1424300

FXR2
RNA-binding protein FXR2

1

11

High-throughput

0.445

High

59196

A2A9M5
Dedicator of cytokinesis 7

1

5

High-throughput

0.437

High

62354

A4FUW1
Regulatory-associated protein of mTOR

1

18

High-throughput

0.437

High

86302

B9EJ72
Teneurin-2

1

4

High-throughput

0.437

High

1296357

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

20

High-throughput

0.437

High

46713

QSER1
Glutamine and serine-rich protein 1

1

5

High-throughput

0.407

High

1341485

DOCK7
Dedicator of cytokinesis protein 7

1

5

High-throughput

0.407

High

1297026

TCAF1
TRPM8 channel-associated factor 1

1

0

High-throughput

0.279

Low

1362905

CYRIB
CYFIP-related Rac1 interactor B

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025